Influence of nuclear structure on the formation of radiation-induced lethal lesions

Purpose The rejoining of fragmented nuclear DNA caused by ionizing radiation may lead to lethal chromosome rearrangements, such as rings or dicentrics. The clinically useful linear quadratic relationship between dose and cell survival has been interpreted as the generation of lethal lesions secondar...

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Bibliographic Details
Published in:	International journal of radiation biology Vol. 92; no. 5; pp. 229 - 240
Main Authors:	Friedman, Daniel A., Tait, Lauren, Vaughan, Andrew T. M.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 03.05.2016
Subjects:	Animals Apoptosis - genetics Apoptosis - radiation effects Cell Nucleus - physiology Cell Nucleus - radiation effects Cellular radiobiology chromosome abberations Chromosome Aberrations - radiation effects Computer Simulation DNA - genetics DNA - radiation effects DNA Damage - physiology Dose-Response Relationship, Radiation double-strand breaks Evidence-Based Medicine Humans microdosimetry models of cell killing Models, Genetic molecular radiobiology Radiation Dosage Cellular radiobiology microdosimetry chromosome abberations molecular radiobiology double-strand breaks models of cell killing
ISSN:	0955-3002, 1362-3095, 1362-3095
Online Access:	Get full text
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