Isolation, characterization and in silico study of propenamide alkaloids from Hymenoepmecis bicolor poison against active μ-opioid receptor

Some insects produce venoms to defend against predators and directly interact with opioid receptors. In the present study, it was identified two alkaloids in the wasp venom species Hymenoepimecis bicolor. It was demonstrated that these could act as potential inhibitors of opioid receptors through th...

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Published in:	Journal of biomolecular structure & dynamics Vol. 41; no. 24; pp. 14621 - 14637
Main Authors:	Marques da Fonseca, Aluísio, Freire da Silva, Ananias, Barbosa da Silva, Francisco Lennon, Caluaco, Bernardino Joaquim, Gaieta, Eduardo Menezes, Nunes da Rocha, Matheus, Colares, Regilany Paulo, Sobczak, Jober Fernando, Marinho, Gabrielle Silva, dos Santos, Hélcio Silva, Marinho, Emmanuel Silva
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 29.12.2023
Subjects:	Alkaloids - pharmacology arthropod chemical composition computational simulation Morphine - chemistry Morphine - pharmacology Poisons Receptors, Opioid Wasp computational simulation arthropod chemical composition Wasp
ISSN:	0739-1102, 1538-0254, 1538-0254
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Abstract	Some insects produce venoms to defend against predators and directly interact with opioid receptors. In the present study, it was identified two alkaloids in the wasp venom species Hymenoepimecis bicolor. It was demonstrated that these could act as potential inhibitors of opioid receptors through their robust affinity to the receptors. The interaction profile was given to opioid receptors (μOR), with 60% of targets similar to alkaloid 1, with 0.25 probability, and 46.7% of targets similar to alkaloid 2, with a probability 0.17 of affinity as a target, which is considered signaling macromolecules and can mediate the most potent analgesic and addictive properties of opiate alkaloids. Notably, both alkaloids showed −7.6 kcal/mol affinity to the morphine agonies through six residues, Gly124, Asp147, Trp293, Ile296, Ile322, and Tyr326. These observations suggest further research on opioid receptors using in vitro studies of possible therapeutic applications. Communicated by Ramaswamy H. Sarma
AbstractList	Some insects produce venoms to defend against predators and directly interact with opioid receptors. In the present study, it was identified two alkaloids in the wasp venom species . It was demonstrated that these could act as potential inhibitors of opioid receptors through their robust affinity to the receptors. The interaction profile was given to opioid receptors (μOR), with 60% of targets similar to alkaloid 1, with 0.25 probability, and 46.7% of targets similar to alkaloid 2, with a probability 0.17 of affinity as a target, which is considered signaling macromolecules and can mediate the most potent analgesic and addictive properties of opiate alkaloids. Notably, both alkaloids showed -7.6 kcal/mol affinity to the morphine agonies through six residues, Gly124, Asp147, Trp293, Ile296, Ile322, and Tyr326. These observations suggest further research on opioid receptors using studies of possible therapeutic applications.Communicated by Ramaswamy H. Sarma. Some insects produce venoms to defend against predators and directly interact with opioid receptors. In the present study, it was identified two alkaloids in the wasp venom species Hymenoepimecis bicolor. It was demonstrated that these could act as potential inhibitors of opioid receptors through their robust affinity to the receptors. The interaction profile was given to opioid receptors (μOR), with 60% of targets similar to alkaloid 1, with 0.25 probability, and 46.7% of targets similar to alkaloid 2, with a probability 0.17 of affinity as a target, which is considered signaling macromolecules and can mediate the most potent analgesic and addictive properties of opiate alkaloids. Notably, both alkaloids showed −7.6 kcal/mol affinity to the morphine agonies through six residues, Gly124, Asp147, Trp293, Ile296, Ile322, and Tyr326. These observations suggest further research on opioid receptors using in vitro studies of possible therapeutic applications. Communicated by Ramaswamy H. Sarma Some insects produce venoms to defend against predators and directly interact with opioid receptors. In the present study, it was identified two alkaloids in the wasp venom species Hymenoepimecis bicolor. It was demonstrated that these could act as potential inhibitors of opioid receptors through their robust affinity to the receptors. The interaction profile was given to opioid receptors (μOR), with 60% of targets similar to alkaloid 1, with 0.25 probability, and 46.7% of targets similar to alkaloid 2, with a probability 0.17 of affinity as a target, which is considered signaling macromolecules and can mediate the most potent analgesic and addictive properties of opiate alkaloids. Notably, both alkaloids showed -7.6 kcal/mol affinity to the morphine agonies through six residues, Gly124, Asp147, Trp293, Ile296, Ile322, and Tyr326. These observations suggest further research on opioid receptors using in vitro studies of possible therapeutic applications.Communicated by Ramaswamy H. Sarma.Some insects produce venoms to defend against predators and directly interact with opioid receptors. In the present study, it was identified two alkaloids in the wasp venom species Hymenoepimecis bicolor. It was demonstrated that these could act as potential inhibitors of opioid receptors through their robust affinity to the receptors. The interaction profile was given to opioid receptors (μOR), with 60% of targets similar to alkaloid 1, with 0.25 probability, and 46.7% of targets similar to alkaloid 2, with a probability 0.17 of affinity as a target, which is considered signaling macromolecules and can mediate the most potent analgesic and addictive properties of opiate alkaloids. Notably, both alkaloids showed -7.6 kcal/mol affinity to the morphine agonies through six residues, Gly124, Asp147, Trp293, Ile296, Ile322, and Tyr326. These observations suggest further research on opioid receptors using in vitro studies of possible therapeutic applications.Communicated by Ramaswamy H. Sarma.
Author	Gaieta, Eduardo Menezes Colares, Regilany Paulo Barbosa da Silva, Francisco Lennon Marinho, Emmanuel Silva Sobczak, Jober Fernando Caluaco, Bernardino Joaquim dos Santos, Hélcio Silva Freire da Silva, Ananias Marques da Fonseca, Aluísio Nunes da Rocha, Matheus Marinho, Gabrielle Silva
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References	Leitão-Filho H. F. (e_1_3_3_56_1) 1992 e_1_3_3_50_1 e_1_3_3_77_1 e_1_3_3_39_1 e_1_3_3_16_1 e_1_3_3_35_1 e_1_3_3_58_1 e_1_3_3_92_1 e_1_3_3_12_1 e_1_3_3_31_1 e_1_3_3_96_1 e_1_3_3_61_1 e_1_3_3_88_1 e_1_3_3_9_1 e_1_3_3_27_1 e_1_3_3_46_1 e_1_3_3_69_1 e_1_3_3_80_1 e_1_3_3_5_1 e_1_3_3_42_1 e_1_3_3_65_1 e_1_3_3_84_1 e_1_3_3_101_1 Pinto H. S. (e_1_3_3_79_1) 1982 e_1_3_3_30_1 e_1_3_3_76_1 e_1_3_3_99_1 e_1_3_3_19_1 e_1_3_3_38_1 e_1_3_3_91_1 e_1_3_3_15_1 e_1_3_3_57_1 e_1_3_3_34_1 e_1_3_3_72_1 e_1_3_3_95_1 e_1_3_3_11_1 e_1_3_3_53_1 e_1_3_3_41_1 e_1_3_3_87_1 Brown T. (e_1_3_3_10_1) 2014; 81 e_1_3_3_60_1 Filmore D. (e_1_3_3_23_1) 2004; 7 e_1_3_3_8_1 e_1_3_3_49_1 e_1_3_3_100_1 e_1_3_3_26_1 e_1_3_3_68_1 e_1_3_3_45_1 e_1_3_3_83_1 e_1_3_3_4_1 e_1_3_3_22_1 e_1_3_3_64_1 e_1_3_3_52_1 e_1_3_3_75_1 e_1_3_3_98_1 e_1_3_3_71_1 e_1_3_3_18_1 Kloss T. G. (e_1_3_3_54_1) 2015 e_1_3_3_14_1 e_1_3_3_37_1 e_1_3_3_90_1 e_1_3_3_33_1 e_1_3_3_40_1 e_1_3_3_63_1 e_1_3_3_86_1 e_1_3_3_7_1 e_1_3_3_29_1 e_1_3_3_25_1 e_1_3_3_48_1 e_1_3_3_21_1 e_1_3_3_44_1 e_1_3_3_67_1 e_1_3_3_82_1 e_1_3_3_97_1 e_1_3_3_51_1 e_1_3_3_78_1 e_1_3_3_70_1 e_1_3_3_17_1 Padua D. G. d. (e_1_3_3_73_1) 2014; 39 e_1_3_3_13_1 e_1_3_3_59_1 Adams R. P. (e_1_3_3_2_1) 2007; 8 e_1_3_3_36_1 e_1_3_3_93_1 e_1_3_3_55_1 e_1_3_3_32_1 e_1_3_3_74_1 e_1_3_3_62_1 e_1_3_3_89_1 e_1_3_3_6_1 e_1_3_3_28_1 Ahmadi M. (e_1_3_3_3_1) 2005; 24 e_1_3_3_24_1 e_1_3_3_47_1 e_1_3_3_81_1 e_1_3_3_20_1 e_1_3_3_66_1 e_1_3_3_43_1 e_1_3_3_85_1 e_1_3_3_102_1
References_xml	– ident: e_1_3_3_96_1 doi: 10.1021/cn100008c – ident: e_1_3_3_69_1 doi: 10.1038/nature07261 – ident: e_1_3_3_57_1 doi: 10.1016/j.compbiolchem.2020.107372 – ident: e_1_3_3_77_1 doi: 10.1002/jcc.20289 – ident: e_1_3_3_29_1 doi: 10.1021/jm701122q – ident: e_1_3_3_82_1 doi: 10.1016/j.jbiotec.2021.06.024 – ident: e_1_3_3_8_1 doi: 10.1136/bmj.310.6973.170 – ident: e_1_3_3_20_1 doi: 10.3389/fphys.2019.01406 – ident: e_1_3_3_88_1 doi: 10.2147/AABC.S63749 – ident: e_1_3_3_19_1 doi: 10.1038/hr.2014.17 – ident: e_1_3_3_41_1 doi: 10.1021/acscentsci.5b00131 – start-page: 30 volume-title: História Natural da Serra do Japi: ecologia e preservacão de uma área florestal no Sudeste do Brasil year: 1982 ident: e_1_3_3_79_1 – ident: e_1_3_3_90_1 – ident: e_1_3_3_51_1 doi: 10.12968/vetn.2021.12.1.40 – ident: e_1_3_3_55_1 doi: 10.1038/nchembio.2334 – ident: e_1_3_3_59_1 doi: 10.1021/acs.jctc.5b00255 – ident: e_1_3_3_18_1 doi: 10.1002/jcc.25072 – ident: e_1_3_3_63_1 doi: 10.1039/d1sc00071c – ident: e_1_3_3_42_1 doi: 10.1016/0263-7855(96)00018-5 – ident: e_1_3_3_21_1 doi: 10.1016/b978-0-08-057116-4.50025-0 – ident: e_1_3_3_38_1 doi: 10.1002/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H – ident: e_1_3_3_85_1 doi: 10.1063/5.0013849 – ident: e_1_3_3_78_1 doi: 10.1016/0306-4492(82)90098-3 – ident: e_1_3_3_75_1 doi: 10.1124/pr.112.007138 – ident: e_1_3_3_72_1 doi: 10.1186/1758-2946-3-33 – ident: e_1_3_3_16_1 doi: 10.1093/aob/mcz159 – ident: e_1_3_3_43_1 doi: 10.4251/wjgo.v13.i6.574 – ident: e_1_3_3_49_1 doi: 10.1016/j.bpj.2013.11.1935 – ident: e_1_3_3_100_1 doi: 10.1016/j.ijbiomac.2013.12.007 – ident: e_1_3_3_95_1 doi: 10.36076/ppj.2011/14/E343 – ident: e_1_3_3_36_1 doi: 10.1063/1.4872239 – ident: e_1_3_3_87_1 doi: 10.1016/j.baae.2017.09.011 – ident: e_1_3_3_7_1 doi: 10.1038/nchem.1243 – ident: e_1_3_3_84_1 doi: 10.1002/jcb.26333 – ident: e_1_3_3_15_1 doi: 10.1016/1074-5521(95)90077-2 – volume-title: Proceedings of the National Academy of Sciences year: 2015 ident: e_1_3_3_54_1 – ident: e_1_3_3_39_1 doi: 10.1038/nature14886 – ident: e_1_3_3_46_1 doi: 10.1063/1.3626941 – volume: 39 start-page: 1 issue: 1 year: 2014 ident: e_1_3_3_73_1 article-title: Taxonomia de Hymenoepimecis Viereck, 1912 (Hymenoptera: Ichneumonidae publication-title: Pimplinae) Na Amazônia Brasileira, – ident: e_1_3_3_80_1 doi: 10.1007/978-1-4939-7756-7_14 – ident: e_1_3_3_93_1 doi: 10.1002/jcc.21334 – ident: e_1_3_3_11_1 doi: 10.1073/pnas.90.12.5391 – ident: e_1_3_3_9_1 doi: 10.1002/prot.26403 – ident: e_1_3_3_4_1 doi: 10.1093/bib/bbaa161 – ident: e_1_3_3_13_1 doi: 10.1053/j.gastro.2020.12.076 – start-page: 40 volume-title: História natural da Serra do Japi: ecologia e preservação de uma área florestal no Sudeste do Brasil year: 1992 ident: e_1_3_3_56_1 – ident: e_1_3_3_12_1 doi: 10.1021/ja00119a045 – ident: e_1_3_3_62_1 doi: 10.1063/1.478193 – ident: e_1_3_3_81_1 doi: 10.3390/molecules25204636 – ident: e_1_3_3_45_1 doi: 10.1016/j.bmcl.2009.08.045 – ident: e_1_3_3_98_1 doi: 10.1016/0305-1978(96)83708-2 – ident: e_1_3_3_91_1 doi: 10.1590/S1519-69842012000100028 – ident: e_1_3_3_6_1 doi: 10.1063/1.448118 – ident: e_1_3_3_68_1 doi: 10.1002/jcc.21256 – ident: e_1_3_3_26_1 doi: 10.1517/17460441.2015.1032936 – ident: e_1_3_3_32_1 doi: 10.1080/03949371003707836 – ident: e_1_3_3_47_1 doi: 10.1063/1.445869 – ident: e_1_3_3_53_1 doi: 10.1126/science.1083853 – ident: e_1_3_3_14_1 doi: 10.1261/rna.065896.118 – ident: e_1_3_3_35_1 doi: 10.1186/1758-2946-4-17 – ident: e_1_3_3_37_1 doi: 10.1038/s41598-017-15571-7 – ident: e_1_3_3_30_1 doi: 10.1002/jcc.10379 – volume: 81 start-page: 67 issue: 2 year: 2014 ident: e_1_3_3_10_1 article-title: ChemDraw publication-title: The Science Teacher, – ident: e_1_3_3_48_1 doi: 10.1016/j.cois.2018.10.001 – ident: e_1_3_3_17_1 doi: 10.1093/nar/gkz382 – ident: e_1_3_3_97_1 doi: 10.1021/acs.jcim.5b00642 – ident: e_1_3_3_28_1 doi: 10.1093/bioinformatics/btt540 – ident: e_1_3_3_66_1 doi: 10.1007/s00894-015-2772-4 – ident: e_1_3_3_74_1 doi: 10.1155/2010/161595 – ident: e_1_3_3_76_1 doi: 10.1111/jcpt.13114 – ident: e_1_3_3_70_1 doi: 10.1016/j.peptides.2018.10.007 – ident: e_1_3_3_65_1 doi: 10.1038/383819a0 – ident: e_1_3_3_92_1 doi: 10.1016/j.toxicon.2004.11.013 – ident: e_1_3_3_71_1 doi: 10.1021/acs.jcim.7b00226 – ident: e_1_3_3_58_1 doi: 10.1021/jp973084f – ident: e_1_3_3_64_1 doi: 10.1039/d1cp04992e – ident: e_1_3_3_89_1 – ident: e_1_3_3_52_1 doi: 10.1002/rcm.1290030906 – ident: e_1_3_3_5_1 doi: 10.1016/j.carbpol.2020.117499 – ident: e_1_3_3_102_1 doi: 10.1021/ci800084x – ident: e_1_3_3_99_1 doi: 10.16476/j.pibb.2020.0187 – volume: 7 start-page: 24 issue: 11 year: 2004 ident: e_1_3_3_23_1 article-title: It’s a GPCR world publication-title: Journal of Modern Drug Discovery, – ident: e_1_3_3_25_1 doi: 10.1111/j.1365-3113.2006.00334.x – ident: e_1_3_3_44_1 doi: 10.3390/molecules26051224 – ident: e_1_3_3_33_1 doi: 10.1016/j.cbi.2008.09.023 – ident: e_1_3_3_31_1 doi: 10.1016/S0022-2836(03)00610-7 – ident: e_1_3_3_101_1 doi: 10.1124/dmd.113.056267 – ident: e_1_3_3_24_1 doi: 10.1093/advances/nmz127 – ident: e_1_3_3_67_1 doi: 10.21068/C2016v17r01a02 – ident: e_1_3_3_50_1 doi: 10.1038/srep38116 – ident: e_1_3_3_61_1 doi: 10.1016/j.micpath.2020.104365 – ident: e_1_3_3_60_1 doi: 10.3390/ijms18020288 – volume: 24 start-page: 1 issue: 2 year: 2005 ident: e_1_3_3_3_1 article-title: Chem3D 15.0 user guide publication-title: Macromolecules, – volume: 8 start-page: 1 issue: 6 year: 2007 ident: e_1_3_3_2_1 article-title: Identification of essential oil components by gas chromatography/mass spectrometry publication-title: Journal of the American Society for Mass Spectrometry, – ident: e_1_3_3_86_1 doi: 10.1016/0021-9991(77)90098-5 – ident: e_1_3_3_27_1 doi: 10.1002/jcc.21366 – ident: e_1_3_3_40_1 doi: 10.1016/j.bmcl.2008.07.071 – ident: e_1_3_3_83_1 doi: 10.1007/s11172-016-1340-0 – ident: e_1_3_3_34_1 doi: 10.1002/(SICI)1096-987X(199604)17:5/6<490::AID-JCC1>3.0.CO;2-P – ident: e_1_3_3_22_1 doi: 10.1002/1096-987X(200009)21:12<1088::AID-JCC5>3.0.CO;2-8
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Snippet	Some insects produce venoms to defend against predators and directly interact with opioid receptors. In the present study, it was identified two alkaloids in...
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SubjectTerms	Alkaloids - pharmacology arthropod chemical composition computational simulation Morphine - chemistry Morphine - pharmacology Poisons Receptors, Opioid Wasp
Title	Isolation, characterization and in silico study of propenamide alkaloids from Hymenoepmecis bicolor poison against active μ-opioid receptor
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