Protective Effect of Raf-1 Kinase Inhibitory Protein on Diabetic Retinal Neurodegeneration through P38-MAPK Pathway

This study aimed to investigate the effect of Raf-1 kinase inhibitory protein (RKIP) on diabetic retinal neurodegeneration in streptozotocin-treated rat model and high glucose-treated rat Müller cells. Control and streptozotocin-treated rats were intravitreally injected with saline, RKIP gene overex...

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Bibliographic Details
Published in:	Current eye research Vol. 47; no. 1; pp. 135 - 142
Main Authors:	Wu, Chuanling, Xu, Kai, Liu, Wenqiang, Liu, Anqi, Liang, Huimin, Li, Qunwang, Feng, Zhen, Yang, Yang, Ding, Jiayuan, Zhang, Tianyi, Liu, Yingxue, Liu, Xuezheng, Zuo, Zhongfu
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 02.01.2022
Subjects:	Animals Apoptosis Diabetes Mellitus, Experimental diabetic retinal neurodegeneration diabetic retinopathy Diabetic Retinopathy - diagnosis Diabetic Retinopathy - genetics Diabetic Retinopathy - metabolism Disease Models, Animal Ependymoglial Cells - pathology Gene Expression Regulation intravitreal injection MAP Kinase Signaling System - genetics Müller cells p38 mitogen-activated protein kinase Proto-Oncogene Proteins c-raf - biosynthesis Proto-Oncogene Proteins c-raf - genetics Raf-1 kinase inhibitory protein Rats Rats, Sprague-Dawley Raf-1 kinase inhibitory protein diabetic retinal neurodegeneration Müller cells intravitreal injection p38 mitogen-activated protein kinase diabetic retinopathy
ISSN:	0271-3683, 1460-2202, 1460-2202
Online Access:	Get full text
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