Osimertinib As First-Line Treatment of EGFR Mutation-Positive Advanced Non-Small-Cell Lung Cancer

Purpose The AURA study ( ClinicalTrials.gov identifier: NCT01802632) included two cohorts of treatment-naïve patients to examine clinical activity and safety of osimertinib (an epidermal growth factor receptor [EGFR] -tyrosine kinase inhibitor selective for EGFR-tyrosine kinase inhibitor sensitizing...

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Veröffentlicht in:	Journal of clinical oncology Jg. 36; H. 9; S. 841
Hauptverfasser:	Ramalingam, Suresh S, Yang, James C-H, Lee, Chee Khoon, Kurata, Takayasu, Kim, Dong-Wan, John, Thomas, Nogami, Naoyuki, Ohe, Yuichiro, Mann, Helen, Rukazenkov, Yuri, Ghiorghiu, Serban, Stetson, Daniel, Markovets, Aleksandra, Barrett, J Carl, Thress, Kenneth S, Jänne, Pasi A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.03.2018
Schlagworte:	Acrylamides Adult Aged Aged, 80 and over Aniline Compounds Antineoplastic Agents - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - genetics ErbB Receptors - blood ErbB Receptors - genetics Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - genetics Male Middle Aged Mutation Piperazines - therapeutic use Progression-Free Survival Protein Kinase Inhibitors - therapeutic use Survival Rate
ISSN:	1527-7755, 1527-7755
Online-Zugang:	Weitere Angaben
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