Immunotherapy-induced autoimmune hypophysitis

Autoimmune hypophysitis is an immune-related adverse event of immune checkpoint inhibitors. In this article, we present the case of a 58-year-old female patient who presented to the emergency room with gradually worsening nonspecific symptoms of headache, nausea, vomiting and decreased oral intake o...

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Bibliographic Details
Published in:Journal of oncology pharmacy practice Vol. 25; no. 1; p. 217
Main Authors: Valecha, Gautam, Pant, Manisha, Ibrahim, Uroosa, Atallah, Jean P
Format: Journal Article
Language:English
Published: England 01.01.2019
Subjects:
Antineoplastic Agents, Immunological - adverse effects
Autoimmune Hypophysitis - chemically induced
Autoimmune Hypophysitis - diagnostic imaging
Female
Humans
Immunotherapy - adverse effects
Ipilimumab - adverse effects
Middle Aged
Nivolumab - adverse effects
adverse events
nivolumab
autoimmune hypophysitis
Immunotherapy
ipilimumab
ISSN:1477-092X, 1477-092X
Online Access:Get more information
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Summary:Autoimmune hypophysitis is an immune-related adverse event of immune checkpoint inhibitors. In this article, we present the case of a 58-year-old female patient who presented to the emergency room with gradually worsening nonspecific symptoms of headache, nausea, vomiting and decreased oral intake of one week duration. The patient had been diagnosed with relapsed extensive stage small cell lung cancer. She was being treated with a combination of ipilimumab and nivolumab after progression on chemotherapy. Gadolinium-enhanced magnetic resonance imaging of head revealed pituitary enlargement up to 1.5 cm and pituitary stalk enlargement up to 4 mm consistent with hypophysitis. The patient was treated with corticosteroids resulting in rapid resolution of her symptoms. The objective of our report is to highlight this rare but important adverse event associated with checkpoint inhibitors, and discuss its clinical features, diagnostic work-up and treatment.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:1477-092X
1477-092X
DOI:10.1177/1078155217727142