Cardioprotective effects of ( E )-4-hydroxy-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide: a newly synthesized coumarin hydrazone against isoproterenol-induced myocardial infarction in a rat model

The current study was carried out to evaluate the effect of pretreatment and co-treatment with a newly synthesized coumarin hydrazone, ( )-4-hydroxy-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide (hereinafter EK6), against isoproterenol-induced myocardial infarction in rats. Cha...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology Vol. 97; no. 10; p. 989
Main Authors: Ghazouani, Lakhdar, Khdhiri, Emna, Elmufti, Afoua, Feriani, Anouar, Tir, Meriam, Baaziz, Intissar, Hajji, Raouf, Ben Mansour, Hedi, Ammar, Houcine, Abid, Souhir, Mnafgui, Kais
Format: Journal Article
Language:English
Published: Canada 01.10.2019
Subjects:
Animals
Benzopyrans - administration & dosage
Benzopyrans - chemical synthesis
Biomarkers - analysis
Cardiotonic Agents - administration & dosage
Cardiotonic Agents - chemical synthesis
Coumarins - administration & dosage
Coumarins - chemical synthesis
Disease Models, Animal
Electrocardiography
Heart - drug effects
Heart Rate - drug effects
Humans
Hydrazones - administration & dosage
Hydrazones - chemical synthesis
Isoproterenol - toxicity
Male
Myocardial Infarction - chemically induced
Myocardial Infarction - diagnosis
Myocardial Infarction - drug therapy
Myocardium - pathology
Rats
Rats, Wistar
Treatment Outcome
dérivé de la coumarine
myocardial infarction
ECG
cardioprotection
isoprotérénol
infarctus du myocarde
isoproterenol
coumarin derivative
ISSN:1205-7541, 1205-7541
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Summary:The current study was carried out to evaluate the effect of pretreatment and co-treatment with a newly synthesized coumarin hydrazone, ( )-4-hydroxy-N'-(1-(3-oxo-3H-benzo[f]chromen-2-yl)ethylidene)benzohydrazide (hereinafter EK6), against isoproterenol-induced myocardial infarction in rats. Changes in biochemistry, cardiac biomarkers, electrocardiography, and histopathology after treatment with EK6 or acenocoumarol (Sintrom) were studied. Animals were randomly divided into 4 groups: vehicle control (C), isoproterenol + Sintrom (ISO + Sin), isoproterenol + EK6 (ISO + EK6), and isoproterenol (ISO). Myocardial infarction was induced by subcutaneous ISO administration at a dose of 85 mg·kg ·day with a drug-free interval of 24 h on days 6 and 7. Treatment with ISO led to significant elevation ( < 0.05) in serum levels of cardiac injury biomarkers, namely cardiac troponin-T, lactate dehydrogenase, creatine kinase-MB, alanine aminotransferase, and aspartate aminotransferase compared with levels in the vehicle control. A change in the lipid profile was also observed as a significant increase in total cholesterol and triglycerides. Furthermore, ISO caused significant alterations in the electrocardiogram pattern, including significant ST-segment elevation, significant decreased R wave amplitude, and significant increase in heart rate (16%) as well as marked changes in the histopathology of the heart tissue. Pretreatment and co-treatment with newly synthesized coumarin hydrazone restored all ISO-induced biochemical, lipid, cardiac, and histopathological changes in rats with myocardial infarction.
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ISSN:1205-7541
1205-7541
DOI:10.1139/cjpp-2019-0085