The expression of insulin signaling and N-methyl-D-aspartate receptor genes in areas of gray matter atrophy is associated with cognitive function in type 2 diabetes

BackgroundType 2 diabetes (T2DM) is associated with brain abnormalities and cognitive dysfunction, including increased risk for Alzheimer's disease. However, the mechanisms of T2DM-related dementia remain poorly understood.ObjectiveWe evaluated the molecular properties of gray matter atrophy an...

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Bibliographic Details
Published in:	Journal of Alzheimer's disease Vol. 107; no. 3; p. 1054
Main Authors:	Kesler, Shelli R, Cuevas, Heather, Lewis, Kimberly A, Franco-Rocha, Oscar Y, Flowers, Elena
Format:	Journal Article
Language:	English
Published:	United States 01.10.2025
Subjects:	Aged Aged, 80 and over Atrophy - pathology Brain - metabolism Brain - pathology Cognition - physiology Cognitive Dysfunction - genetics Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnostic imaging Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - psychology Female Gray Matter - diagnostic imaging Gray Matter - metabolism Gray Matter - pathology Humans Insulin - metabolism Magnetic Resonance Imaging Male Middle Aged Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Retrospective Studies Signal Transduction - genetics Signal Transduction - physiology type 2 diabetes Alzheimer's disease transcriptome neuroimaging
ISSN:	1875-8908, 1875-8908
Online Access:	Get more information
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