Protein-protein docking by simulating the process of association subject to biochemical constraints

We present a computational procedure for modeling protein–protein association and predicting the structures of protein–protein complexes. The initial sampling stage is based on an efficient Brownian dynamics algorithm that mimics the physical process of diffusional association. Relevant biochemical...

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Bibliographic Details
Published in:	Proteins, structure, function, and bioinformatics Vol. 71; no. 4; pp. 1955 - 1969
Main Authors:	Motiejunas, Domantas, Gabdoulline, Razif, Wang, Ting, Feldman-Salit, Anna, Johann, Tim, Winn, Peter J., Wade, Rebecca C.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2008
Subjects:	Algorithms Amino Acid Sequence Animals Biochemical Phenomena Biochemistry Brownian dynamics clustering Computational Biology - methods Computer Simulation Crystallography, X-Ray Databases, Factual Diffusion encounter complex flexible refinement Fourier Analysis Humans Hydrogen Bonding Models, Biological molecular dynamics Molecular Sequence Data Osmolar Concentration Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary protein-protein association protein-protein docking Proteins - chemistry Proteins - metabolism Static Electricity
ISSN:	0887-3585, 1097-0134, 1097-0134
Online Access:	Get full text
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