Novel aspects of Raman spectroscopy in skin research

The analytical technology of Raman spectroscopy has an almost 100‐year history. During this period, many modifications and developments happened in the method like discovery of laser, improvements in optical elements and sensitivity of spectrometer and also more advanced light detection systems. Man...

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Published in:Experimental dermatology Vol. 31; no. 9; pp. 1311 - 1329
Main Authors: Lunter, Dominique, Klang, Victoria, Kocsis, Dorottya, Varga‐Medveczky, Zsófia, Berkó, Szilvia, Erdő, Franciska
Format: Journal Article
Language:English
Published: Chichester Wiley Subscription Services, Inc 01.09.2022
Subjects:
Artificial intelligence
cosmetoscience
Dermatology
Microscopy
Raman spectroscopy
Skin
skin composition
skin diagnostics
skin research
Spectrum analysis
topical drug penetration
ISSN:0906-6705, 1600-0625, 1600-0625
Online Access:Get full text
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Summary:The analytical technology of Raman spectroscopy has an almost 100‐year history. During this period, many modifications and developments happened in the method like discovery of laser, improvements in optical elements and sensitivity of spectrometer and also more advanced light detection systems. Many types of the innovative techniques appeared (e.g. Transmittance Raman spectroscopy, Coherent Raman Scattering microscopy, Surface‐Enhanced Raman scattering and Confocal Raman spectroscopy/microscopy). This review article gives a short description about these different Raman techniques and their possible applications. Then, a short statistical part is coming about the appearance of Raman spectroscopy in the scientific literature from the beginnings to these days. The third part of the paper shows the main application options of the technique (especially confocal Raman spectroscopy) in skin research, including skin composition analysis, drug penetration monitoring and analysis, diagnostic utilizations in dermatology and cosmeto‐scientific applications. At the end, the possible role of artificial intelligence in Raman data analysis and the regulatory aspect of these techniques in dermatology are briefly summarized. For the future of Raman Spectroscopy, increasing clinical relevance and in vivo applications can be predicted with spreading of non‐destructive methods and appearance with the most advanced instruments with rapid analysis time.
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ISSN:0906-6705
1600-0625
1600-0625
DOI:10.1111/exd.14645