β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps

Rodent-borne hantaviruses are emerging human pathogens that cause severe human disease. The underlying mechanisms are not well understood, as hantaviruses replicate in endothelial and epithelial cells without causing any cytopathic effect. We demonstrate that hantaviruses strongly stimulated neutrop...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 211; no. 7; p. 1485
Main Authors:	Raftery, Martin J, Lalwani, Pritesh, Krautkrӓmer, Ellen, Peters, Thorsten, Scharffetter-Kochanek, Karin, Krüger, Renate, Hofmann, Jörg, Seeger, Karl, Krüger, Detlev H, Schönrich, Günther
Format:	Journal Article
Language:	English
Published:	United States 30.06.2014
Subjects:	Adenoviridae Animals Autoantibodies - genetics Autoantibodies - immunology CD18 Antigens - genetics CD18 Antigens - immunology CHO Cells Cricetinae Cricetulus Female Hantavirus - immunology Hantavirus Infections - genetics Hantavirus Infections - immunology Hantavirus Infections - pathology Humans Integrin alphaXbeta2 - genetics Integrin alphaXbeta2 - immunology Kidney Diseases - genetics Kidney Diseases - immunology Kidney Diseases - pathology Kidney Diseases - virology Lung Diseases - genetics Lung Diseases - immunology Lung Diseases - pathology Lung Diseases - virology Macrophage-1 Antigen - genetics Macrophage-1 Antigen - immunology Male Mice Mice, Mutant Strains Neutrophils - immunology Neutrophils - pathology
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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