Pressure enabled drug delivery (PEDD) of nelitolimod increased therapeutic delivery, reduced immunosuppression, and improved efficacy in porcine and murine liver tumor models

Direct tumoral needle injection of nelitolimod, also known as SD-101, has been evaluated in patients with superficial malignancies, including cutaneous melanoma, with encouraging outcomes. Direct intra-tumoral injections may not be suitable for primary and metastatic liver tumors due to the number a...

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Bibliographic Details

Published in:	Frontiers in oncology Vol. 15; p. 1655794
Main Authors:	Cournoyer, Lauren, Liu, Yujia, Jaroch, David B., Hullinger, Tom G., Cox, Bryan F., Katz, Steven C., LaPorte, Jason, Layman, Ilan B., Ballarin, Alizee, Ghosh, Chandra C., Guha, Prajna
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 2025
Subjects:	liver metastases loco-regional therapy NIR-tissue imaging oncopig SD-101 tumor microenvironment loco-regional therapy NIR-tissue imaging SD-101 TLR9 agonist oncopig tumor microenvironment liver metastases nelitolimod
ISSN:	2234-943X, 2234-943X
Online Access:	Get full text
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