Enhancement of nasal and intestinal calcitonin delivery by the novel Pheroid™ fatty acid based delivery system, and by N-trimethyl chitosan chloride

Therapeutic peptides are highly potent and specific in their functions, but difficulties in their administration require parallel development of viable delivery systems to improve their bioavailability. In this study the potential of a novel lipid-based colloidal delivery system for improving the ab...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 385; no. 1; pp. 181 - 186
Main Authors:	du Plessis, L.H., Lubbe, J., Strauss, T., Kotzé, A.F.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 29.01.2010
Subjects:	Administration, Intranasal Administration, Oral Animals Calcitonin - administration & dosage Calcitonin - blood Calcitonin - chemistry Calcitonin - pharmacokinetics Chemistry, Pharmaceutical Chitosan - chemistry Colloids Dosage Forms Drug Carriers Fatty Acids - chemistry Intestinal Absorption Intestinal drug delivery Jejunum - metabolism Liposomes Male N-Trimethyl chitosan chloride (TMC) Nasal drug delivery Particle Size Pheroid™ technology Rats Rats, Sprague-Dawley Salmon calcitonin (sCT) Technology, Pharmaceutical - methods N-Trimethyl chitosan chloride (TMC) Nasal drug delivery Pheroid™ technology Salmon calcitonin (sCT) Intestinal drug delivery
ISSN:	0378-5173, 1873-3476, 1873-3476
Online Access:	Get full text
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