Engineered Adoptive T-cell Therapy Prolongs Survival in a Preclinical Model of Advanced-Stage Ovarian Cancer

Adoptive T-cell therapy using high-affinity T-cell receptors (TCR) to target tumor antigens has potential for improving outcomes in high-grade serous ovarian cancer (HGSOC) patients. Ovarian tumors develop a hostile, multicomponent tumor microenvironment containing suppressive cells, inhibitory liga...

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Bibliographic Details
Published in:	Cancer immunology research Vol. 7; no. 9; p. 1412
Main Authors:	Anderson, Kristin G, Voillet, Valentin, Bates, Breanna M, Chiu, Edison Y, Burnett, Madison G, Garcia, Nicolas M, Oda, Shannon K, Morse, Christopher B, Stromnes, Ingunn M, Drescher, Charles W, Gottardo, Raphael, Greenberg, Philip D
Format:	Journal Article
Language:	English
Published:	United States 01.09.2019
Subjects:	Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Cytotoxicity, Immunologic Disease Models, Animal Female Gene Expression Gene Expression Profiling Genetic Engineering GPI-Linked Proteins - genetics GPI-Linked Proteins - immunology HLA-A Antigens - genetics HLA-A Antigens - immunology Humans Immunophenotyping Immunotherapy, Adoptive - adverse effects Immunotherapy, Adoptive - methods Mesothelin Mice Neoplasm Grading Neoplasm Staging Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Prognosis Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism Treatment Outcome Xenograft Model Antitumor Assays
ISSN:	2326-6074, 2326-6074
Online Access:	Get more information
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