Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis in Il19 -/- × Ldlr -/- Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR (Human Antigen R)

To test the hypothesis that loss of IL-19 (interleukin-19) exacerbates atherosclerosis. APPROACH AND RESULTS: mice were crossed into (low-density lipoprotein receptor knock out) mice. Double knockout (dKO) mice had increased plaque burden in aortic arch and root compared with controls after 14 weeks...

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Bibliographic Details

Published in:	Arteriosclerosis, thrombosis, and vascular biology Vol. 38; no. 6; p. 1297
Main Authors:	Ray, Mitali, Gabunia, Khatuna, Vrakas, Christine N, Herman, Allison B, Kako, Farah, Kelemen, Sheri E, Grisanti, Laurel A, Autieri, Michael V
Format:	Journal Article
Language:	English
Published:	United States 01.06.2018
Subjects:	atherosclerosis endothelial cells macrophages cytokines bone marrow
ISSN:	1524-4636, 1524-4636
Online Access:	Get more information
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