Determination of skin penetration profiles by confocal Raman microspectroscopy: Evaluation of interindividual variability and interlab comparability

Confocal Raman microspectroscopy is being increasingly used to investigate the skin penetration of actives and excipients. The aim of the present study was to compare results obtained with skin from different donors, acquired with two Raman systems: the RiverD gen2 Skin Composition Analyzer and the...

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Published in:Journal of Raman spectroscopy Vol. 51; no. 7; pp. 1037 - 1043
Main Authors: Binder, Lisa, Valenta, Claudia, Lunter, Dominique
Format: Journal Article
Language:English
Published: Bognor Regis Wiley Subscription Services, Inc 01.07.2020
Subjects:
enhancer
Hydrogels
Penetration
procaine
Skin
ISSN:0377-0486, 1097-4555
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Abstract Confocal Raman microspectroscopy is being increasingly used to investigate the skin penetration of actives and excipients. The aim of the present study was to compare results obtained with skin from different donors, acquired with two Raman systems: the RiverD gen2 Skin Composition Analyzer and the WiTec alpha 500 instrument. To elucidate the interindividual variability between the skin donors and to find out whether the two systems would give similar results in skin penetration analysis, we compared the penetration of the model drug procaine from hydrogel formulations with or without the penetration enhancer POE‐23‐lauryl ether. Penetration was investigated with both systems on skin from three different skin donors, each. Penetration plots were prepared by plotting the signal intensity of a typical peak of procaine against the skin depth. We then calculated the enhancement ratio from the areas under the curves of the penetration plots of procaine that had penetrated from the formulation with or without the enhancer. They ranged between 2.0 and 3.1 for the WiTec system and between 2.1 and 3.1 for the RiverD system. Thus, we found that both systems provide similar estimations of the skin penetration of procaine. Results of skin penetration analysis by two commonly used confocal Raman microspectroscopy systems was found to be comparable between two laboratories.
AbstractList Confocal Raman microspectroscopy is being increasingly used to investigate the skin penetration of actives and excipients. The aim of the present study was to compare results obtained with skin from different donors, acquired with two Raman systems: the RiverD gen2 Skin Composition Analyzer and the WiTec alpha 500 instrument. To elucidate the interindividual variability between the skin donors and to find out whether the two systems would give similar results in skin penetration analysis, we compared the penetration of the model drug procaine from hydrogel formulations with or without the penetration enhancer POE‐23‐lauryl ether. Penetration was investigated with both systems on skin from three different skin donors, each. Penetration plots were prepared by plotting the signal intensity of a typical peak of procaine against the skin depth. We then calculated the enhancement ratio from the areas under the curves of the penetration plots of procaine that had penetrated from the formulation with or without the enhancer. They ranged between 2.0 and 3.1 for the WiTec system and between 2.1 and 3.1 for the RiverD system. Thus, we found that both systems provide similar estimations of the skin penetration of procaine.
Confocal Raman microspectroscopy is being increasingly used to investigate the skin penetration of actives and excipients. The aim of the present study was to compare results obtained with skin from different donors, acquired with two Raman systems: the RiverD gen2 Skin Composition Analyzer and the WiTec alpha 500 instrument. To elucidate the interindividual variability between the skin donors and to find out whether the two systems would give similar results in skin penetration analysis, we compared the penetration of the model drug procaine from hydrogel formulations with or without the penetration enhancer POE‐23‐lauryl ether. Penetration was investigated with both systems on skin from three different skin donors, each. Penetration plots were prepared by plotting the signal intensity of a typical peak of procaine against the skin depth. We then calculated the enhancement ratio from the areas under the curves of the penetration plots of procaine that had penetrated from the formulation with or without the enhancer. They ranged between 2.0 and 3.1 for the WiTec system and between 2.1 and 3.1 for the RiverD system. Thus, we found that both systems provide similar estimations of the skin penetration of procaine. Results of skin penetration analysis by two commonly used confocal Raman microspectroscopy systems was found to be comparable between two laboratories.
Author Binder, Lisa
Lunter, Dominique
Valenta, Claudia
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Cites_doi 10.1016/j.ejpb.2012.06.010
10.1016/j.ijpharm.2014.05.007
10.1159/000348464
10.1159/000444806
10.1016/j.ijpharm.2004.08.012
10.1016/j.ijpharm.2015.09.018
10.1016/j.ejpb.2013.09.018
10.1016/j.jdermsci.2017.08.002
10.1039/c2an16115j
10.1016/j.ejpb.2016.04.018
10.1016/j.ejpb.2018.07.007
10.1046/j.1523-1747.2001.01258.x
10.1016/j.ejpb.2018.02.006
10.1016/j.addr.2015.02.006
10.1002/jps.23944
10.1007/s11095-010-0250-3
10.1111/srt.12709
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Lunter D. J. (e_1_2_8_5_1) 2016
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e_1_2_8_6_1
e_1_2_8_9_1
e_1_2_8_8_1
Heck R. (e_1_2_8_11_1) 2014
Heck R. (e_1_2_8_20_1) 2016; 108
e_1_2_8_10_1
e_1_2_8_21_1
e_1_2_8_22_1
e_1_2_8_12_1
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References_xml – volume: 19
  year: 2014
  publication-title: R. Daniels
– volume: 29
  start-page: 92
  year: 2016
  publication-title: Skin Pharmacol Physiol
– volume: 103
  start-page: 1515
  year: 2014
  publication-title: J. Pharm. Sci.
– volume: 127
  start-page: 61
  year: 2018
  publication-title: Eur J Pharm Biopharm
– start-page: 152
  year: 2016
  publication-title: J Raman Spectr
– volume: 495
  start-page: 482
  year: 2015
  publication-title: Int. J. Pharm.
– volume: 82
  start-page: 291
  year: 2012
  publication-title: Eur J Pharm Biopharm
– volume: 88
  start-page: 280
  year: 2017
  publication-title: J Dermatol Sci
– year: 2001
– volume: 116
  start-page: 434
  year: 2001
  publication-title: J. Invest. Dermatol.
– volume: 26
  start-page: 139
  year: 2012
  publication-title: Skin Pharmacol Physiol
– volume: 27
  start-page: 2590
  year: 2010
  publication-title: Pharm. Res.
– volume: 130
  start-page: 214
  year: 2018
  publication-title: Eur J Pharm Biopharm
– volume: 21
  start-page: 4241
  year: 2012
  publication-title: Analyst
– volume: 104
  start-page: 51
  year: 2016
  publication-title: Eur J Pharm Biopharm
– volume: 108
  start-page: 1
  year: 2016
  publication-title: Eur. J. Pharm. Sci.
– year: 2014
– volume: 470
  start-page: 88
  year: 2014
  publication-title: Int. J. Pharm.
– volume: 86
  start-page: 260
  year: 2014
  publication-title: Eur J Pharm Biopharm
– volume: 89
  start-page: 71
  year: 2015
  publication-title: Adv. Drug Delivery Rev.
– volume: 287
  start-page: 73
  year: 2004
  publication-title: Int. J. Pharm.
– year: 1998
– ident: e_1_2_8_19_1
  doi: 10.1016/j.ejpb.2012.06.010
– volume-title: In Skin Forum 14th annual meeting Prague
  year: 2014
  ident: e_1_2_8_11_1
– volume: 19
  start-page: 126015
  year: 2014
  ident: e_1_2_8_3_1
  publication-title: R. Daniels
– ident: e_1_2_8_13_1
  doi: 10.1016/j.ijpharm.2014.05.007
– ident: e_1_2_8_24_1
– ident: e_1_2_8_12_1
  doi: 10.1159/000348464
– ident: e_1_2_8_4_1
  doi: 10.1159/000444806
– start-page: 152
  year: 2016
  ident: e_1_2_8_5_1
  publication-title: J Raman Spectr
– ident: e_1_2_8_15_1
  doi: 10.1016/j.ijpharm.2004.08.012
– ident: e_1_2_8_10_1
  doi: 10.1016/j.ijpharm.2015.09.018
– ident: e_1_2_8_18_1
  doi: 10.1016/j.ejpb.2013.09.018
– ident: e_1_2_8_22_1
– ident: e_1_2_8_9_1
  doi: 10.1016/j.jdermsci.2017.08.002
– ident: e_1_2_8_8_1
  doi: 10.1039/c2an16115j
– volume: 108
  start-page: 1
  year: 2016
  ident: e_1_2_8_20_1
  publication-title: Eur. J. Pharm. Sci.
– ident: e_1_2_8_6_1
  doi: 10.1016/j.ejpb.2016.04.018
– ident: e_1_2_8_7_1
  doi: 10.1016/j.ejpb.2018.07.007
– ident: e_1_2_8_2_1
  doi: 10.1046/j.1523-1747.2001.01258.x
– ident: e_1_2_8_17_1
  doi: 10.1016/j.ejpb.2018.02.006
– ident: e_1_2_8_14_1
  doi: 10.1016/j.addr.2015.02.006
– ident: e_1_2_8_16_1
  doi: 10.1002/jps.23944
– ident: e_1_2_8_23_1
  doi: 10.1007/s11095-010-0250-3
– ident: e_1_2_8_21_1
  doi: 10.1111/srt.12709
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Snippet Confocal Raman microspectroscopy is being increasingly used to investigate the skin penetration of actives and excipients. The aim of the present study was to...
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Hydrogels
Penetration
procaine
Skin
Title Determination of skin penetration profiles by confocal Raman microspectroscopy: Evaluation of interindividual variability and interlab comparability
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