Hormone imbalances detected in study participants with pre-diabetes in a Durban-based clinical setting, South Africa

Background Type II diabetes mellitus onset is linked with hormonal imbalances. However, the knowledge about hormonal alterations in pre-diabetes is limited. Objective The study aimed to examine type II diabetes mellitus-associated hormone levels during the pre-diabetes phase in participants aged 25–...

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Published in:International journal of diabetes in developing countries Vol. 45; no. 2; pp. 416 - 423
Main Authors: Sosibo, Aubrey M., Mzimela, Nomusa C., Ngubane, Phikelelani S., Khathi, Andile
Format: Journal Article
Language:English
Published: New Delhi Springer India 01.06.2025
Springer Nature B.V
Subjects:
Anemia
Correlation analysis
Developing countries
Diabetes
Diabetes mellitus
Family Medicine
Females
Gender
General Practice
Glucose
Health Administration
Hemoglobin
Hormones
Hyperglycemia
Insulin resistance
LDCs
Medicine
Medicine & Public Health
Metabolism
Original Article
Peptides
Steroid hormones
Testosterone
Thyroid gland
United States > US
South Africa
Incretins
Pre-diabetes
Glycated haemoglobin
Thyroid hormones
Intermediate hyperglycaemia
Adipokines
Sex steroids
ISSN:0973-3930, 1998-3832
Online Access:Get full text
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Summary:Background Type II diabetes mellitus onset is linked with hormonal imbalances. However, the knowledge about hormonal alterations in pre-diabetes is limited. Objective The study aimed to examine type II diabetes mellitus-associated hormone levels during the pre-diabetes phase in participants aged 25–45 in a Durban-based clinical setting in South Africa. Methods Stored plasma samples from a retrospective study collected 364 samples that were divided into pre-diabetes and non-pre-diabetes groups. From the 364, 38 samples from the group of persons without pre-diabetes and 38 from persons with glycated haemoglobin determined pre-diabetes were blindly selected. The hormone concentrations (C-peptide, cortisol, adipokines, thyroids, incretins, and sex steroids) of the study participants were measured using the BIO-RAD Bio-Plex MAGPIX instrument. Results Hormone imbalances in several hormones were detected in study participants with pre-diabetes. Most of the hormone dysregulation associated with T2DM begins in pre-diabetes but at a moderate level. Conclusion The findings reveal new possible hormone therapy targets for pre-diabetes and contribute to the growing support for targeting pre-diabetes as a preventative measure for T2DM prevention.
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ISSN:0973-3930
1998-3832
DOI:10.1007/s13410-024-01363-z