Quantification of blood flow in brain tumors: comparison of arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging
To implement an arterial spin labeling technique that is feasible in routine examinations and to test the method and compare it with dynamic susceptibility-weighted contrast material-enhanced magnetic resonance (MR) imaging for evaluation of tumor blood flow (TBF) in patients with brain tumors. Thir...
Saved in:
| Published in: | Radiology Vol. 228; no. 2; p. 523 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
01.08.2003
|
| Subjects: | |
| ISSN: | 0033-8419 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | To implement an arterial spin labeling technique that is feasible in routine examinations and to test the method and compare it with dynamic susceptibility-weighted contrast material-enhanced magnetic resonance (MR) imaging for evaluation of tumor blood flow (TBF) in patients with brain tumors.
Thirty-six patients with histologically proven brain tumors were examined at 1.5 T. A second version of quantitative imaging of perfusion by using a single subtraction with addition of thin-section periodic saturation after inversion and a time delay (Q2TIPS) technique of pulsed arterial spin labeling in the multisection mode was implemented. After arterial spin labeling, a combined T2- and T2*-weighted first-pass bolus perfusion study (gadopentetate dimeglumine, 0.2 mmol/kg) was performed by using a double-echo echo-planar imaging sequence. In regions of interest, maps of absolute and relative cerebral blood flow were computed and analyzed with arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging, respectively.
Both techniques yielded the highest perfusion values in imaging of glioblastomas and the lowest values in imaging of two low-grade gliomas that both showed strong gadopentetate dimeglumine enhancement. There was a close linear correlation between dynamic susceptibility-weighted contrast-enhanced MR imaging and arterial spin labeling in the tumor region of interest (linear regression coefficient, R = 0.83; P <.005). Blood flow is underestimated with arterial spin labeling at low flow rates. High- and low-grade gliomas can be distinguished at the same level of significance with both methods. Absolute TBF is less important for tumor grading than is the ratio of TBF to age-dependent mean brain perfusion.
Arterial spin labeling is a suitable method for assessment of microvascular perfusion and allows distinction between high- and low-grade gliomas. |
|---|---|
| AbstractList | To implement an arterial spin labeling technique that is feasible in routine examinations and to test the method and compare it with dynamic susceptibility-weighted contrast material-enhanced magnetic resonance (MR) imaging for evaluation of tumor blood flow (TBF) in patients with brain tumors.
Thirty-six patients with histologically proven brain tumors were examined at 1.5 T. A second version of quantitative imaging of perfusion by using a single subtraction with addition of thin-section periodic saturation after inversion and a time delay (Q2TIPS) technique of pulsed arterial spin labeling in the multisection mode was implemented. After arterial spin labeling, a combined T2- and T2*-weighted first-pass bolus perfusion study (gadopentetate dimeglumine, 0.2 mmol/kg) was performed by using a double-echo echo-planar imaging sequence. In regions of interest, maps of absolute and relative cerebral blood flow were computed and analyzed with arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging, respectively.
Both techniques yielded the highest perfusion values in imaging of glioblastomas and the lowest values in imaging of two low-grade gliomas that both showed strong gadopentetate dimeglumine enhancement. There was a close linear correlation between dynamic susceptibility-weighted contrast-enhanced MR imaging and arterial spin labeling in the tumor region of interest (linear regression coefficient, R = 0.83; P <.005). Blood flow is underestimated with arterial spin labeling at low flow rates. High- and low-grade gliomas can be distinguished at the same level of significance with both methods. Absolute TBF is less important for tumor grading than is the ratio of TBF to age-dependent mean brain perfusion.
Arterial spin labeling is a suitable method for assessment of microvascular perfusion and allows distinction between high- and low-grade gliomas. To implement an arterial spin labeling technique that is feasible in routine examinations and to test the method and compare it with dynamic susceptibility-weighted contrast material-enhanced magnetic resonance (MR) imaging for evaluation of tumor blood flow (TBF) in patients with brain tumors.PURPOSETo implement an arterial spin labeling technique that is feasible in routine examinations and to test the method and compare it with dynamic susceptibility-weighted contrast material-enhanced magnetic resonance (MR) imaging for evaluation of tumor blood flow (TBF) in patients with brain tumors.Thirty-six patients with histologically proven brain tumors were examined at 1.5 T. A second version of quantitative imaging of perfusion by using a single subtraction with addition of thin-section periodic saturation after inversion and a time delay (Q2TIPS) technique of pulsed arterial spin labeling in the multisection mode was implemented. After arterial spin labeling, a combined T2- and T2*-weighted first-pass bolus perfusion study (gadopentetate dimeglumine, 0.2 mmol/kg) was performed by using a double-echo echo-planar imaging sequence. In regions of interest, maps of absolute and relative cerebral blood flow were computed and analyzed with arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging, respectively.MATERIALS AND METHODSThirty-six patients with histologically proven brain tumors were examined at 1.5 T. A second version of quantitative imaging of perfusion by using a single subtraction with addition of thin-section periodic saturation after inversion and a time delay (Q2TIPS) technique of pulsed arterial spin labeling in the multisection mode was implemented. After arterial spin labeling, a combined T2- and T2*-weighted first-pass bolus perfusion study (gadopentetate dimeglumine, 0.2 mmol/kg) was performed by using a double-echo echo-planar imaging sequence. In regions of interest, maps of absolute and relative cerebral blood flow were computed and analyzed with arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging, respectively.Both techniques yielded the highest perfusion values in imaging of glioblastomas and the lowest values in imaging of two low-grade gliomas that both showed strong gadopentetate dimeglumine enhancement. There was a close linear correlation between dynamic susceptibility-weighted contrast-enhanced MR imaging and arterial spin labeling in the tumor region of interest (linear regression coefficient, R = 0.83; P <.005). Blood flow is underestimated with arterial spin labeling at low flow rates. High- and low-grade gliomas can be distinguished at the same level of significance with both methods. Absolute TBF is less important for tumor grading than is the ratio of TBF to age-dependent mean brain perfusion.RESULTSBoth techniques yielded the highest perfusion values in imaging of glioblastomas and the lowest values in imaging of two low-grade gliomas that both showed strong gadopentetate dimeglumine enhancement. There was a close linear correlation between dynamic susceptibility-weighted contrast-enhanced MR imaging and arterial spin labeling in the tumor region of interest (linear regression coefficient, R = 0.83; P <.005). Blood flow is underestimated with arterial spin labeling at low flow rates. High- and low-grade gliomas can be distinguished at the same level of significance with both methods. Absolute TBF is less important for tumor grading than is the ratio of TBF to age-dependent mean brain perfusion.Arterial spin labeling is a suitable method for assessment of microvascular perfusion and allows distinction between high- and low-grade gliomas.CONCLUSIONArterial spin labeling is a suitable method for assessment of microvascular perfusion and allows distinction between high- and low-grade gliomas. |
| Author | Gunther, Matthias Warmuth, Carsten Zimmer, Claus |
| Author_xml | – sequence: 1 givenname: Carsten surname: Warmuth fullname: Warmuth, Carsten organization: Department of Neuroradiology, Charité Medical School, Humboldt University of Berlin, Schumannstrasse 20-21, D-10098 Berlin, Germany – sequence: 2 givenname: Matthias surname: Gunther fullname: Gunther, Matthias – sequence: 3 givenname: Claus surname: Zimmer fullname: Zimmer, Claus |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12819338$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kMlKBDEURbNocf4AN5KVu2ozVHUSdyJOoIii6-ZlqDaSSsokhfR3-MMWqJv74HE4XO4BWsQUHUInlCwpbeV5ButTWDImGWGkJWqB9gnhvJEtVXvooJQPQmjbSbGL9iiTVHEu99H38wSx-t4bqD5FnHqsQ0oW9yF9YR-xzjBnnYaUywU2aRgh-_JLQq4uewi4jDMTQLvg4wZDtNhuIwze4DIV48bqtQ--bpsv5zfv1dlZFGuGUhsX3yGa-fP4gv0Am1lwhHZ6CMUd_91D9HZz_Xp11zw83d5fXT40hq94bUD1TJpWUa41KNF33FgDkjjFOr4C21uhO6mJFMpBy5ymQnCizMpyoYSj7BCd_XrHnD4nV-p68HPbECC6NJW14CvSCtbN4OkfOOnB2fWY56Z5u_6fkf0AGUB5kg |
| CitedBy_id | crossref_primary_10_1007_s00234_015_1497_5 crossref_primary_10_1259_bjr_66316279 crossref_primary_10_1038_s41598_020_62658_9 crossref_primary_10_1002_jmri_20206 crossref_primary_10_1016_j_mri_2007_07_003 crossref_primary_10_1002_nbm_3124 crossref_primary_10_1158_1078_0432_CCR_07_0658 crossref_primary_10_1016_j_radcr_2021_06_082 crossref_primary_10_3389_fonc_2025_1647254 crossref_primary_10_1007_s00234_006_0122_z crossref_primary_10_1016_j_ejrad_2017_10_005 crossref_primary_10_1097_01_rmr_0000245464_36148_dc crossref_primary_10_1007_s00234_016_1756_0 crossref_primary_10_1016_j_ncl_2008_09_015 crossref_primary_10_1002_mrm_21317 crossref_primary_10_1097_WCO_0b013e328318402a crossref_primary_10_1148_radiol_2521081059 crossref_primary_10_1186_s13014_020_01643_y crossref_primary_10_1007_s11060_012_0997_y crossref_primary_10_1007_s11547_024_01923_7 crossref_primary_10_1007_s00062_011_0126_x crossref_primary_10_1016_j_ejro_2021_100378 crossref_primary_10_1148_radiol_2343040359 crossref_primary_10_1227_01_neu_0000279316_03266_cd crossref_primary_10_1093_jnci_dji023 crossref_primary_10_1002_jmri_24026 crossref_primary_10_1007_s00330_015_3755_7 crossref_primary_10_3390_pharmaceutics14020451 crossref_primary_10_1016_j_crad_2004_09_009 crossref_primary_10_1016_j_neurad_2007_11_007 crossref_primary_10_1007_s00259_017_3777_2 crossref_primary_10_1016_j_ejrad_2014_07_002 crossref_primary_10_1007_s11060_017_2604_8 crossref_primary_10_1007_s00381_012_1741_9 crossref_primary_10_3389_fneur_2020_00005 crossref_primary_10_1111_j_1552_6569_2012_00703_x crossref_primary_10_1097_RCT_0000000000001180 crossref_primary_10_1148_radiol_2016150789 crossref_primary_10_1097_RCT_0b013e31814cf81f crossref_primary_10_1177_197140090702000203 crossref_primary_10_2217_iim_09_30 crossref_primary_10_1016_j_acra_2009_10_024 crossref_primary_10_1007_s11060_015_1908_9 crossref_primary_10_1177_197140091202500109 crossref_primary_10_1002_jmri_20579 crossref_primary_10_1161_01_STR_0000177884_72657_8b crossref_primary_10_1053_j_seminoncol_2014_06_006 crossref_primary_10_1161_STROKEAHA_111_635979 crossref_primary_10_1016_j_nic_2010_04_008 crossref_primary_10_3390_cancers15143577 crossref_primary_10_1016_j_ejrad_2016_08_009 crossref_primary_10_1097_RMR_0b013e31821e570a crossref_primary_10_1148_radiol_2015142156 crossref_primary_10_1007_s00234_021_02794_9 crossref_primary_10_1016_j_critrevonc_2006_01_004 crossref_primary_10_1016_j_ejrad_2019_01_008 crossref_primary_10_1007_s11060_014_1666_0 crossref_primary_10_1017_S1355617707070634 crossref_primary_10_1258_ar_2012_120191 crossref_primary_10_1007_s00234_015_1571_z crossref_primary_10_1016_S1064_9689_03_00070_9 crossref_primary_10_1093_neuonc_nop006 crossref_primary_10_3171_2015_8_JNS151211 crossref_primary_10_1007_s11517_015_1332_5 crossref_primary_10_1093_neuros_nyw108 crossref_primary_10_3390_bs12020048 crossref_primary_10_3390_cancers14061432 crossref_primary_10_1016_j_clinimag_2020_04_006 crossref_primary_10_1007_s00234_012_1089_6 crossref_primary_10_1002_jmri_25489 crossref_primary_10_1007_s00062_017_0590_z crossref_primary_10_1016_j_radonc_2015_12_017 crossref_primary_10_1148_radiol_2393042031 crossref_primary_10_1097_CCO_0000000000000896 crossref_primary_10_4103_neurol_india_NI_317_20 crossref_primary_10_1007_s10334_021_00975_4 crossref_primary_10_1007_s00117_004_1048_2 crossref_primary_10_1177_0284185112474916 crossref_primary_10_1016_S0150_9861_05_83159_1 crossref_primary_10_1007_s00330_018_5359_5 crossref_primary_10_1016_j_hoc_2004_06_011 crossref_primary_10_1016_j_wneu_2016_06_004 crossref_primary_10_1371_journal_pone_0166662 crossref_primary_10_1007_s00234_018_1992_6 crossref_primary_10_1038_nrclinonc_2011_62 crossref_primary_10_1016_j_crad_2016_10_016 crossref_primary_10_1016_j_pmr_2016_01_002 crossref_primary_10_1016_j_mric_2008_12_002 crossref_primary_10_1007_s11547_025_02048_1 crossref_primary_10_1016_S0028_3770_05_83490_3 crossref_primary_10_1007_s00234_019_02358_y crossref_primary_10_1007_s00330_019_06474_4 crossref_primary_10_1002_mrm_24520 crossref_primary_10_1177_19714009231193163 crossref_primary_10_1186_s12880_020_00450_x crossref_primary_10_1097_RMR_0000000000000065 crossref_primary_10_1155_2017_6053879 crossref_primary_10_1016_j_ejca_2016_10_037 crossref_primary_10_1016_j_actbio_2019_05_051 crossref_primary_10_3892_etm_2016_3225 crossref_primary_10_1002_jmri_24178 crossref_primary_10_1016_j_ejrad_2008_06_033 crossref_primary_10_1007_s00330_013_3057_x crossref_primary_10_1016_j_mric_2012_08_001 crossref_primary_10_1016_j_neurad_2013_04_005 crossref_primary_10_1016_j_mric_2023_08_005 crossref_primary_10_1007_s00330_010_1870_z crossref_primary_10_1016_j_ejrad_2016_05_015 crossref_primary_10_1259_bjr_20200661 crossref_primary_10_1002_jmri_25022 crossref_primary_10_1016_j_heliyon_2023_e17615 crossref_primary_10_3389_fnhum_2019_00350 crossref_primary_10_1016_j_jns_2006_02_015 crossref_primary_10_1007_s00234_018_2021_5 crossref_primary_10_1007_s11604_011_0025_8 crossref_primary_10_1016_j_neuchi_2008_03_007 crossref_primary_10_3389_fonc_2022_874924 crossref_primary_10_3892_ol_2019_10656 crossref_primary_10_1016_j_heliyon_2021_e07615 crossref_primary_10_1007_s11060_020_03475_y crossref_primary_10_1016_j_neuroimage_2016_09_007 crossref_primary_10_1007_s11910_005_0009_0 crossref_primary_10_1097_01_rli_0000119195_50515_04 crossref_primary_10_4329_wjr_v2_i10_384 crossref_primary_10_1016_j_mri_2011_07_026 crossref_primary_10_1148_radiol_2016152228 crossref_primary_10_1097_RLI_0b013e3181ec9db0 crossref_primary_10_1517_14728222_11_4_473 crossref_primary_10_1016_j_acra_2015_09_013 crossref_primary_10_3390_diagnostics12061444 crossref_primary_10_1016_j_neurad_2010_12_003 crossref_primary_10_1186_s43055_025_01517_x crossref_primary_10_1007_s00330_019_06379_2 crossref_primary_10_1016_j_neuroimage_2016_03_054 crossref_primary_10_1016_j_nic_2005_11_005 crossref_primary_10_3389_fneur_2021_733323 crossref_primary_10_1016_j_clineuro_2011_12_022 crossref_primary_10_1148_radiol_14140130 crossref_primary_10_1002_jmri_24751 crossref_primary_10_1016_j_radonc_2019_05_020 crossref_primary_10_1002_nbm_1210 crossref_primary_10_1007_s10334_007_0073_3 crossref_primary_10_1155_2014_108691 crossref_primary_10_1016_j_nicl_2019_101696 crossref_primary_10_1016_j_cpet_2013_03_003 crossref_primary_10_1109_TMI_2006_886807 crossref_primary_10_1016_j_pscychresns_2010_01_009 crossref_primary_10_1007_s11060_014_1586_z crossref_primary_10_1007_s00330_009_1675_0 crossref_primary_10_1371_journal_pone_0075717 crossref_primary_10_1016_j_xphs_2017_06_019 crossref_primary_10_1586_14737140_6_5_733 crossref_primary_10_1148_radiol_12111740 crossref_primary_10_3389_fneur_2015_00033 crossref_primary_10_3390_cancers13122960 crossref_primary_10_1148_radiol_2351031663 crossref_primary_10_1002_jmri_24421 crossref_primary_10_3171_JNS_07_09_0600 crossref_primary_10_1042_BSR20180507 crossref_primary_10_1177_153303460400300605 crossref_primary_10_1097_00002142_200402000_00003 crossref_primary_10_1016_j_mri_2014_01_016 crossref_primary_10_1007_s00062_011_0073_6 crossref_primary_10_1007_s11060_023_04290_x crossref_primary_10_1002_cam4_177 crossref_primary_10_1016_j_wneu_2015_09_048 crossref_primary_10_1016_j_neuroimage_2017_08_062 crossref_primary_10_3390_cancers16030576 crossref_primary_10_1016_j_neuroimage_2007_11_053 crossref_primary_10_1002_jmri_25191 crossref_primary_10_1093_neuonc_noy095 crossref_primary_10_1200_JCO_2010_32_6082 crossref_primary_10_1002_nbm_3297 crossref_primary_10_1016_j_mri_2010_05_002 crossref_primary_10_29001_2073_8552_2025_40_2_32_43 crossref_primary_10_1148_radiol_2453061932 crossref_primary_10_1016_j_neuroimage_2020_117031 crossref_primary_10_1016_j_neurad_2024_101211 crossref_primary_10_3390_jcm10112387 crossref_primary_10_1007_s11864_008_0052_6 crossref_primary_10_1007_s00330_021_08406_7 crossref_primary_10_1007_s00234_009_0616_6 crossref_primary_10_1177_197140091302600405 crossref_primary_10_1007_s00234_015_1574_9 crossref_primary_10_1002_tox_23800 crossref_primary_10_1259_bjr_67705974 crossref_primary_10_1016_j_clinimag_2011_11_003 crossref_primary_10_1097_MD_0000000000016012 crossref_primary_10_1371_journal_pone_0099616 crossref_primary_10_1002_nbm_2915 crossref_primary_10_1002_jmri_23586 crossref_primary_10_1007_s00234_011_0977_5 crossref_primary_10_3390_cancers15112992 crossref_primary_10_3390_diagnostics12102450 crossref_primary_10_3389_fnins_2022_856808 crossref_primary_10_1007_s00247_011_2280_3 crossref_primary_10_1007_s10334_011_0255_x crossref_primary_10_1016_j_nurt_2007_04_005 crossref_primary_10_1016_j_neuroimage_2019_01_004 crossref_primary_10_1517_14712598_8_4_541 crossref_primary_10_1002_nbm_2904 crossref_primary_10_1097_RCT_0b013e318282d7e2 crossref_primary_10_1212_01_wnl_0000219767_49705_9c crossref_primary_10_1016_j_ncl_2013_08_002 crossref_primary_10_1517_17460441_2_11_1477 crossref_primary_10_1016_j_addr_2014_07_010 crossref_primary_10_1016_j_nicl_2020_102447 crossref_primary_10_3348_kjr_2016_17_5_598 crossref_primary_10_3892_etm_2017_4370 crossref_primary_10_1186_s41747_021_00243_z crossref_primary_10_1016_j_mric_2009_01_008 crossref_primary_10_1016_j_acra_2010_08_002 crossref_primary_10_1016_j_clon_2023_08_001 crossref_primary_10_1002_jmri_20415 crossref_primary_10_1002_nbm_1231 crossref_primary_10_1148_rg_220088 crossref_primary_10_1038_s41598_022_05992_4 crossref_primary_10_1016_j_wneu_2020_07_039 crossref_primary_10_1016_j_neurad_2021_01_002 crossref_primary_10_1259_bjr_20150624 crossref_primary_10_1002_mrm_21403 crossref_primary_10_1586_14737140_7_11_1537 crossref_primary_10_1007_s00117_006_1406_3 crossref_primary_10_1016_j_nic_2012_02_012 crossref_primary_10_1586_14737175_8_10_1507 |
| ContentType | Journal Article |
| Copyright | Copyright RSNA, 2003. |
| Copyright_xml | – notice: Copyright RSNA, 2003. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1148/radiol.2282020409 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| ExternalDocumentID | 12819338 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GroupedDBID | --- .55 .GJ 123 18M 1CY 1KJ 29P 2WC 34G 39C 4.4 53G 5RE 6NX 6PF 7FM AAEJM AAQQT AAWTL ABDPE ABHFT ABOCM ACFQH ACGFO ACJAN ACRZS ADBBV AENEX AENYM AFFNX AFOSN AJJEV AJWWR ALMA_UNASSIGNED_HOLDINGS BAWUL CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P F9R GX1 H13 J5H KO8 L7B LMP LSO MJL MV1 N4W NPM OK1 P2P R.V RKKAF RXW SJN TAE TR2 TRS TWZ VXZ W8F WH7 WOQ X7M YQI YQJ ZGI ZKG ZVN ZXP 7X8 |
| ID | FETCH-LOGICAL-c363t-a9f28c4913bba97f53cdca80e92536adfd7b58b0879ea42eb177309c6d3797e12 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 291 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000184381100034&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0033-8419 |
| IngestDate | Fri Sep 05 09:18:53 EDT 2025 Wed Feb 19 01:34:25 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | Copyright RSNA, 2003. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c363t-a9f28c4913bba97f53cdca80e92536adfd7b58b0879ea42eb177309c6d3797e12 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 12819338 |
| PQID | 73604725 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_73604725 pubmed_primary_12819338 |
| PublicationCentury | 2000 |
| PublicationDate | 2003-Aug 20030801 |
| PublicationDateYYYYMMDD | 2003-08-01 |
| PublicationDate_xml | – month: 08 year: 2003 text: 2003-Aug |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Radiology |
| PublicationTitleAlternate | Radiology |
| PublicationYear | 2003 |
| SSID | ssj0014587 |
| Score | 2.2707598 |
| Snippet | To implement an arterial spin labeling technique that is feasible in routine examinations and to test the method and compare it with dynamic... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 523 |
| SubjectTerms | Adolescent Adult Aged Brain Neoplasms - blood supply Brain Neoplasms - pathology Cerebrovascular Circulation - physiology Child Contrast Media Female Gadolinium DTPA Glioma - blood supply Glioma - pathology Humans Image Processing, Computer-Assisted Linear Models Magnetic Resonance Imaging - methods Male Microcirculation Middle Aged Perfusion Spin Labels Statistics, Nonparametric |
| Title | Quantification of blood flow in brain tumors: comparison of arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/12819338 https://www.proquest.com/docview/73604725 |
| Volume | 228 |
| WOSCitedRecordID | wos000184381100034&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3JTsMwELUKRYgL-1JWH7gakjibERJCiIpLq4JA6q1yvIhKkJSmpeI7-GHGkxRucOCSk6NE9rP97Hkzj5BT39pQhiZmkRUeC5XPGfA4zTwNkylUUWxiiWYTSbeb9vui1yCX81wYJ6ucr4m4UOtCuTvy84THrrBhdDV6Y84zysVWawONBdLkQGQcppP-TwwhjNKqYiaH74e-qGOawP_Px1IPi5ezAM4bLjnU-4Vf4j7TXvvfH66T1Zpf0usKEBukYfJNstypI-hb5PN-Kit9EA4JLSxF7Tq1L8WMDnOaOc8IOpm-FuPygqpvm0LXEvWfAFhajqAN4AeT2anMNdWVsz0tpyUKZVBz-8FmePNqNEVJvCwnzOTPKDqgnQc6fEWPpG3y1L59vLljtTEDUzzmEyaFDVIVCp9nmRSJjbjSSqaeEUHEY6mtTrIozbw0EUaGgXElrrgnVKx5IhLjBztkMS9ys0coIEVHLlUoA8gAnZAiUFLAjplpIHaWt8jJvLMHAHwXzZC5KablYN7dLbJbjddgVNXnGGBwEI7e-3--e0BWUJyHgr5D0rQw5c0RWVLvk2E5PkY8wbPb63wB_BfZYg |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quantification+of+blood+flow+in+brain+tumors%3A+comparison+of+arterial+spin+labeling+and+dynamic+susceptibility-weighted+contrast-enhanced+MR+imaging&rft.jtitle=Radiology&rft.au=Warmuth%2C+Carsten&rft.au=Gunther%2C+Matthias&rft.au=Zimmer%2C+Claus&rft.date=2003-08-01&rft.issn=0033-8419&rft.volume=228&rft.issue=2&rft.spage=523&rft_id=info:doi/10.1148%2Fradiol.2282020409&rft_id=info%3Apmid%2F12819338&rft_id=info%3Apmid%2F12819338&rft.externalDocID=12819338 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0033-8419&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0033-8419&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0033-8419&client=summon |