Physiological declines in sex steroid exposure in relation to changes in body composition in healthy men - a prospective cohort study
Androgen levels decline from early adulthood and decreases are steeper in men with increasing body mass index. It is, however, unclear to what extent changes in other indices of body composition and metabolism associate with changes in sex steroid levels in healthy men. Therefore, this study investi...
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| Published in: | European journal of endocrinology Vol. 188; no. 6; p. 510 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
07.06.2023
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| ISSN: | 1479-683X, 1479-683X |
| Online Access: | Get more information |
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| Abstract | Androgen levels decline from early adulthood and decreases are steeper in men with increasing body mass index. It is, however, unclear to what extent changes in other indices of body composition and metabolism associate with changes in sex steroid levels in healthy men. Therefore, this study investigated longitudinal changes in body composition and metabolic health in relation to sex steroid levels in healthy adult men.
Longitudinal, population-based study. 676 healthy men aged 24-46 years were measured at baseline and after ± 12 years.
Serum sex hormone binding globulin (SHBG) was measured using immuno-assay, testosterone (T), estradiol (E2), dihydrotestosterone using LC-MS/MS, free T and E2 (cFE2) and homeostasis model for insulin resistance (HOMA-IR) were calculated. Grip strength was measured by hand grip dynamometry. Body composition was determined using dual-energy x-ray absorptiometry and peripheral quantitative computed tomography.
Mean fat mass (FM), lean mass (LM) and HOMA-IR increased (all p<0.001). Decreasing androgen and SHBG levels were associated with increasing FM, whereas decreasing (cF)E2 levels were associated with decreasing FM (all p<0.005). Decreasing (cF)E2 levels and increasing SHBG levels associated with decreasing LM (all p<0.002). Changes in sex steroid levels and HOMA-IR or grip strength were not interrelated.
Aging leads to increases in fat mass indices and insulin resistance, whereas changes in parameters of lean mass are less unequivocal. In healthy adult men physiological changes in sex steroid exposure clearly correlate with changes in adiposity but not so with lean mass, insulin resistance or grip strength. |
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| AbstractList | Androgen levels decline from early adulthood and decreases are steeper in men with increasing body mass index. It is, however, unclear to what extent changes in other indices of body composition and metabolism associate with changes in sex steroid levels in healthy men. Therefore, this study investigated longitudinal changes in body composition and metabolic health in relation to sex steroid levels in healthy adult men.
Longitudinal, population-based study. 676 healthy men aged 24-46 years were measured at baseline and after ± 12 years.
Serum sex hormone binding globulin (SHBG) was measured using immuno-assay, testosterone (T), estradiol (E2), dihydrotestosterone using LC-MS/MS, free T and E2 (cFE2) and homeostasis model for insulin resistance (HOMA-IR) were calculated. Grip strength was measured by hand grip dynamometry. Body composition was determined using dual-energy x-ray absorptiometry and peripheral quantitative computed tomography.
Mean fat mass (FM), lean mass (LM) and HOMA-IR increased (all p<0.001). Decreasing androgen and SHBG levels were associated with increasing FM, whereas decreasing (cF)E2 levels were associated with decreasing FM (all p<0.005). Decreasing (cF)E2 levels and increasing SHBG levels associated with decreasing LM (all p<0.002). Changes in sex steroid levels and HOMA-IR or grip strength were not interrelated.
Aging leads to increases in fat mass indices and insulin resistance, whereas changes in parameters of lean mass are less unequivocal. In healthy adult men physiological changes in sex steroid exposure clearly correlate with changes in adiposity but not so with lean mass, insulin resistance or grip strength. Androgen levels decline from early adulthood and decreases are steeper in men with increasing body mass index. It is, however, unclear to what extent changes in other indices of body composition and metabolism associate with changes in sex steroid levels in healthy men. Therefore, this study investigated longitudinal changes in body composition and metabolic health in relation to sex steroid levels in healthy adult men.OBJECTIVEAndrogen levels decline from early adulthood and decreases are steeper in men with increasing body mass index. It is, however, unclear to what extent changes in other indices of body composition and metabolism associate with changes in sex steroid levels in healthy men. Therefore, this study investigated longitudinal changes in body composition and metabolic health in relation to sex steroid levels in healthy adult men.This is a longitudinal, population-based study. A total of 676 healthy men aged 24-46 years were measured at baseline and after ±12 years.DESIGNThis is a longitudinal, population-based study. A total of 676 healthy men aged 24-46 years were measured at baseline and after ±12 years.Serum sex hormone-binding globulin (SHBG) was measured by immunoassay, testosterone (T), estradiol (E2), and dihydrotestosterone byliquid chromatography with tandem mass spectrometry (LC-MS/MS), calculated free T and calculated free E2 (cFE2), and homeostasis model assessment for insulin resistance (HOMA-IR) were calculated. Grip strength was measured by hand-grip dynamometry. Body composition was determined using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography.METHODSSerum sex hormone-binding globulin (SHBG) was measured by immunoassay, testosterone (T), estradiol (E2), and dihydrotestosterone byliquid chromatography with tandem mass spectrometry (LC-MS/MS), calculated free T and calculated free E2 (cFE2), and homeostasis model assessment for insulin resistance (HOMA-IR) were calculated. Grip strength was measured by hand-grip dynamometry. Body composition was determined using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography.Mean fat mass (FM), lean mass (LM), and HOMA-IR increased (all P < .001). Decreasing androgen and SHBG levels was associated with increasing FM, whereas decreasing (cF)E2 levels were associated with decreasing FM (all P < .005). Decreasing (cF)E2 levels and increasing SHBG levels associated with decreasing LM (all P < .002). Changes in sex steroid levels and HOMA-IR or grip strength were not interrelated.RESULTSMean fat mass (FM), lean mass (LM), and HOMA-IR increased (all P < .001). Decreasing androgen and SHBG levels was associated with increasing FM, whereas decreasing (cF)E2 levels were associated with decreasing FM (all P < .005). Decreasing (cF)E2 levels and increasing SHBG levels associated with decreasing LM (all P < .002). Changes in sex steroid levels and HOMA-IR or grip strength were not interrelated.Aging leads to increases in FM indices and insulin resistance, whereas changes in parameters of LM are less unequivocal. In healthy adult men, physiological changes in sex steroid exposure clearly correlate with changes in adiposity but not so with lean mass, insulin resistance, or grip strength.CONCLUSIONAging leads to increases in FM indices and insulin resistance, whereas changes in parameters of LM are less unequivocal. In healthy adult men, physiological changes in sex steroid exposure clearly correlate with changes in adiposity but not so with lean mass, insulin resistance, or grip strength.The SIBEX study was registered on ClinicalTrials.gov (#NVT02997033).CLINICAL TRIALThe SIBEX study was registered on ClinicalTrials.gov (#NVT02997033). |
| Author | Reyns, Tim Kaufman, Jean-Marc Lapauw, Bruno T'Sjoen, Guy Fiers, Tom Verroken, Charlotte Banica, Thiberiu |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37288537$$D View this record in MEDLINE/PubMed |
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| Copyright | The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Endocrinology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
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| Keywords | sex steroids body composition grip strength aging insulin resistance |
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