Nucleotide-binding domain-like receptor protein 3 inflammasome contributes to vascular endothelial barrier dysfunction and shock after burn injury

Burn injury-induced systemic inflammation significantly contributes to vascular endothelial dysfunction and hypotension. This study aimed to investigate the role of the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome in vascular endothelial barrier dysfunction following burn i...

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Bibliographic Details
Published in:	Burns Vol. 51; no. 7; p. 107589
Main Authors:	Yu, Huilin, Lyu, Fengjie, Cheng, Zhe, Luo, Minghao, Sasmita, Bryan Richard, Lan, Yuan, Lv, Dingyi
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.09.2025
Subjects:	Animals Burn injury Burns - complications Burns - immunology Burns - metabolism Cytokines - metabolism Disease Models, Animal Endothelial barrier dysfunction Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Furans Human Umbilical Vein Endothelial Cells - metabolism Humans Indenes - pharmacology Inflammasomes - metabolism Inflammation Interleukin-1beta - immunology Interleukin-1beta - metabolism Male Mice Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Pyroptosis Rats Shock Shock - immunology Shock - metabolism Sulfonamides THP-1 Cells Shock NLRP3 Inflammation Pyroptosis Endothelial barrier dysfunction Burn injury
ISSN:	0305-4179, 1879-1409, 1879-1409
Online Access:	Get full text
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