Accelerating burn wound healing using alginate/carboxymethyl cellulose nanogel containing Tussilago farfara and ZnO nanoparticle

The use of hydrogel-based drug delivery systems can help achieve the functional integrity of the skin after injury. This study focuses on preparing alginate/carboxymethylcellulose/zinc oxide nanoparticles/Tussilago farfara hydrogel and evaluates its regenerative effects on burn wounds. Zinc oxide na...

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Veröffentlicht in:Burns Jg. 51; H. 9; S. 107700
Hauptverfasser: kolarijani, Nariman Rezaei, Zamani, Sepehr, Gharibshahian, Maliheh, Aldaghi, Niloofar, Semyari, Hossein, Vaez, Ahmad, Rahmati, Majid, Sohrabi, Sina, Hedayat, Farhad, Gharravi, Anneh mohammad, Salehi, Majid
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier Ltd 01.12.2025
Schlagworte:
Alginates - pharmacology
And Hydrogel
Animals
Anti-Bacterial Agents - pharmacology
Burns - drug therapy
Burns - pathology
Burns - therapy
Carboxymethylcellulose Sodium - pharmacology
Hydrogels
Male
Nanogels
Nanoparticles
Plant Extracts
Pseudomonas aeruginosa - drug effects
Rats
Re-Epithelialization - drug effects
Skin Regeneration
Staphylococcus aureus - drug effects
Wound Healing - drug effects
Zinc Oxide
Zinc Oxide - pharmacology
Nanoparticles
And Hydrogel
Zinc Oxide
Plant Extracts
Skin Regeneration
ISSN:0305-4179, 1879-1409, 1879-1409
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Zusammenfassung:The use of hydrogel-based drug delivery systems can help achieve the functional integrity of the skin after injury. This study focuses on preparing alginate/carboxymethylcellulose/zinc oxide nanoparticles/Tussilago farfara hydrogel and evaluates its regenerative effects on burn wounds. Zinc oxide nanoparticles (ZnONPs) act as an antibacterial agent, while Tussilago farfara (T. farfara) facilitates the wound healing processes. Characteristics of hydrogel treatment groups, in vivo studies, and histopathological evaluation were assessed 14 days after treatment. The hydrogels were fully characterized and tested in vitro and in a rat model for biocompatibility and wound-healing efficacy. The results showed a porous structure, favorable swelling and degradation rates, optimal blood compatibility and blood clotting index, and blood absorption capacity. Biocompatibility was confirmed by MTT assay. T. farfara/ZnONPs-containing hydrogels showed antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. The histopathological results showed more complete re-epithelialization and tissue regeneration compared to the other investigated groups. The initial outcomes suggest that the alginate/carboxymethylcellulose/ZnO/T. farfara hydrogel could be a good way to treat burn wounds, but more research is needed to confirm this. •Alginate/CMC/ZnO/TF hydrogel enhances burn healing via antibacterial/regenerative action.•Hydrogel shows optimal porosity, swelling, blood compatibility, and biocompatibility.•TF/ZnONP hydrogel combats S. aureus and P. aeruginosa, reducing burn infection risks.•In vivo: Accelerated re-epithelialization, and tissue regeneration in 14 days.•Multifunctional biocompatible hydrogel improves burn management and skin restoration.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0305-4179
1879-1409
1879-1409
DOI:10.1016/j.burns.2025.107700