CXCL13 and CXCR5 are upregulated in PCOS mice ovaries but downregulated following metformin administration
Polycystic ovary syndrome (PCOS) is becoming a common pathology among women, yet its pathogenesis remains enigmatic. The chemokine C-X-C motif ligand 13 (CXCL13) and its receptor type 5 (CXCR5) regulate inflammatory responses but their roles in PCOS remain unknown. Metformin is commonly administered...
Saved in:
| Published in: | Molecular and cellular endocrinology Vol. 556; p. 111730 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier B.V
01.10.2022
|
| Subjects: | |
| ISSN: | 0303-7207, 1872-8057, 1872-8057 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Polycystic ovary syndrome (PCOS) is becoming a common pathology among women, yet its pathogenesis remains enigmatic. The chemokine C-X-C motif ligand 13 (CXCL13) and its receptor type 5 (CXCR5) regulate inflammatory responses but their roles in PCOS remain unknown. Metformin is commonly administered to PCOS patients but its mechanism of action remains unclear. Thus, we aimed to determine the expression of CXCL13 and CXCR5 in the ovaries of PCOS mice and to evaluate the therapeutic effect of metformin on them. The study comprised four groups of mice: control, PCOS, PCOS plus metformin, and PCOS plus vehicle. CXCL13 and CXCR5 were found to be elevated in the ovarian tissues of the PCOS mice. Metformin reduced ovarian CXCL13 and CXCR5 expressions in the PCOS mice. Hence, CXCL13 and CXCR5 are potentially involved in PCOS pathogenesis; and metformin may help alleviate the symptoms of PCOS by inhibiting CXCL13 expression and actions.
•Serum CXCL13 concentrations were higher in PCOS mice than in normal controls but could be reversed by metformin.•Metformin administration improved hormonal levels and the lipid profile of PCOS mice.•Metformin administration partially resolved ovarian morphology in PCOS mice. |
|---|---|
| AbstractList | Polycystic ovary syndrome (PCOS) is becoming a common pathology among women, yet its pathogenesis remains enigmatic. The chemokine C-X-C motif ligand 13 (CXCL13) and its receptor type 5 (CXCR5) regulate inflammatory responses but their roles in PCOS remain unknown. Metformin is commonly administered to PCOS patients but its mechanism of action remains unclear. Thus, we aimed to determine the expression of CXCL13 and CXCR5 in the ovaries of PCOS mice and to evaluate the therapeutic effect of metformin on them. The study comprised four groups of mice: control, PCOS, PCOS plus metformin, and PCOS plus vehicle. CXCL13 and CXCR5 were found to be elevated in the ovarian tissues of the PCOS mice. Metformin reduced ovarian CXCL13 and CXCR5 expressions in the PCOS mice. Hence, CXCL13 and CXCR5 are potentially involved in PCOS pathogenesis; and metformin may help alleviate the symptoms of PCOS by inhibiting CXCL13 expression and actions.Polycystic ovary syndrome (PCOS) is becoming a common pathology among women, yet its pathogenesis remains enigmatic. The chemokine C-X-C motif ligand 13 (CXCL13) and its receptor type 5 (CXCR5) regulate inflammatory responses but their roles in PCOS remain unknown. Metformin is commonly administered to PCOS patients but its mechanism of action remains unclear. Thus, we aimed to determine the expression of CXCL13 and CXCR5 in the ovaries of PCOS mice and to evaluate the therapeutic effect of metformin on them. The study comprised four groups of mice: control, PCOS, PCOS plus metformin, and PCOS plus vehicle. CXCL13 and CXCR5 were found to be elevated in the ovarian tissues of the PCOS mice. Metformin reduced ovarian CXCL13 and CXCR5 expressions in the PCOS mice. Hence, CXCL13 and CXCR5 are potentially involved in PCOS pathogenesis; and metformin may help alleviate the symptoms of PCOS by inhibiting CXCL13 expression and actions. Polycystic ovary syndrome (PCOS) is becoming a common pathology among women, yet its pathogenesis remains enigmatic. The chemokine C-X-C motif ligand 13 (CXCL13) and its receptor type 5 (CXCR5) regulate inflammatory responses but their roles in PCOS remain unknown. Metformin is commonly administered to PCOS patients but its mechanism of action remains unclear. Thus, we aimed to determine the expression of CXCL13 and CXCR5 in the ovaries of PCOS mice and to evaluate the therapeutic effect of metformin on them. The study comprised four groups of mice: control, PCOS, PCOS plus metformin, and PCOS plus vehicle. CXCL13 and CXCR5 were found to be elevated in the ovarian tissues of the PCOS mice. Metformin reduced ovarian CXCL13 and CXCR5 expressions in the PCOS mice. Hence, CXCL13 and CXCR5 are potentially involved in PCOS pathogenesis; and metformin may help alleviate the symptoms of PCOS by inhibiting CXCL13 expression and actions. •Serum CXCL13 concentrations were higher in PCOS mice than in normal controls but could be reversed by metformin.•Metformin administration improved hormonal levels and the lipid profile of PCOS mice.•Metformin administration partially resolved ovarian morphology in PCOS mice. Polycystic ovary syndrome (PCOS) is becoming a common pathology among women, yet its pathogenesis remains enigmatic. The chemokine C-X-C motif ligand 13 (CXCL13) and its receptor type 5 (CXCR5) regulate inflammatory responses but their roles in PCOS remain unknown. Metformin is commonly administered to PCOS patients but its mechanism of action remains unclear. Thus, we aimed to determine the expression of CXCL13 and CXCR5 in the ovaries of PCOS mice and to evaluate the therapeutic effect of metformin on them. The study comprised four groups of mice: control, PCOS, PCOS plus metformin, and PCOS plus vehicle. CXCL13 and CXCR5 were found to be elevated in the ovarian tissues of the PCOS mice. Metformin reduced ovarian CXCL13 and CXCR5 expressions in the PCOS mice. Hence, CXCL13 and CXCR5 are potentially involved in PCOS pathogenesis; and metformin may help alleviate the symptoms of PCOS by inhibiting CXCL13 expression and actions. |
| ArticleNumber | 111730 |
| Author | Wang, Ying-Xiong Wang, Mei-Jiao Pervaz, Sadaf Guo, Man Czika, Armin Ullah, Amin Adu-Gyamfi, Enoch Appiah |
| Author_xml | – sequence: 1 givenname: Amin surname: Ullah fullname: Ullah, Amin organization: Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People’s Republic of China – sequence: 2 givenname: Sadaf surname: Pervaz fullname: Pervaz, Sadaf organization: Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People’s Republic of China – sequence: 3 givenname: Enoch Appiah surname: Adu-Gyamfi fullname: Adu-Gyamfi, Enoch Appiah organization: Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People’s Republic of China – sequence: 4 givenname: Armin surname: Czika fullname: Czika, Armin organization: Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People’s Republic of China – sequence: 5 givenname: Man surname: Guo fullname: Guo, Man organization: Department of Physiology of School of Basic Medicine, Chongqing Medical University, Chongqing, People’s Republic of China – sequence: 6 givenname: Mei-Jiao surname: Wang fullname: Wang, Mei-Jiao email: meijiaowang@cqmu.edu.cn organization: Joint International Research Laboratory of Reproduction and Development, School of Public Health, Chongqing Medical University, Chongqing, People’s Republic of China – sequence: 7 givenname: Ying-Xiong surname: Wang fullname: Wang, Ying-Xiong email: yxwang@cqmu.edu.cn organization: Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People’s Republic of China |
| BookMark | eNqFkU9r3DAQxUVJoJs_H6A3HXPxVtLYlk1OxbRpYCGlTSA3oZXGQYstbSU5od--SjZQyCG9zLzD-w28eSfkyAePhHzibM0Zbz_v1rPBtWBCrDnnEtgHsuKdFFXHGnlEVgwYVFIw-ZGcpLRjjMlGdCuyG-6HDQeqvaVF_myojkiXfcSHZdIZLXWe_hhuftHZGaThUUeHiW6XTG148v9sY5im8OT8A50xjyHOhdO2TJdy1NkFf0aORz0lPH_dp-Tu29fb4Xu1ubm6Hr5sKgMt5KrFzrZbNnJuJAPRQG3kFnDkdaNN0ajrDoDZHhrouR3lKEBD35pemr5tajglF4e7-xh-L5iyml0yOE3aY1iSEpJ3UPeiF_-3tn3XAmc1L1Z5sJoYUoo4KuPyS64Sz02KM_VchNqpUoR6LkIdiigkf0Puo5t1_PMuc3lgsDzq0WFUyTj0Bq2LaLKywb1D_wX-OKFJ |
| CitedBy_id | crossref_primary_10_1016_j_gendis_2025_101606 crossref_primary_10_1016_j_arr_2024_102505 crossref_primary_10_1038_s41420_023_01524_9 crossref_primary_10_1016_j_bbadis_2023_166704 crossref_primary_10_1016_j_ejmech_2025_118065 crossref_primary_10_1080_10495398_2025_2510320 crossref_primary_10_1016_j_bbrc_2024_149782 crossref_primary_10_1016_j_intimp_2024_112491 crossref_primary_10_1002_ijc_70132 crossref_primary_10_1007_s10735_025_10512_5 |
| Cites_doi | 10.1177/0960327111426589 10.1016/j.avsg.2020.06.039 10.1002/ar.1092310206 10.1210/edrv.20.4.0374 10.1016/S0303-7207(99)00239-7 10.1111/j.1365-2265.2005.02302.x 10.4049/jimmunol.0903710 10.1016/j.cyto.2008.12.025 10.1186/s12974-016-0652-1 10.1530/rep.1.00095 10.1042/BCJ20190709 10.1089/jir.2005.25.702 10.1016/j.bbi.2019.05.020 10.1016/j.fertnstert.2011.11.023 10.1038/35876 10.4049/jimmunol.188.Supp.161.14 10.1093/biolre/iox054 10.1159/000505452 10.1007/s43032-021-00577-4 10.1186/s13073-021-00922-x 10.1016/j.fertnstert.2010.03.077 10.3389/fendo.2018.00675 10.1016/S0015-0282(02)04925-7 10.1155/2020/5150684 10.1080/09513590.2017.1320383 10.1080/gye.16.5.361.364 10.1084/jem.187.4.655 10.1530/rep.1.00941 10.1038/modpathol.2010.98 10.1006/meth.2001.1262 10.1210/jc.2012-1259 10.1186/s12957-021-02440-x 10.1186/gb-2006-7-12-243 10.1210/jc.2015-4275 10.3109/19396368.2012.743197 10.1093/biolre/ioab050 10.1016/j.metabol.2019.02.002 10.1084/jem.192.11.1545 10.1016/j.abb.2019.06.009 10.1159/000513671 10.1073/pnas.1708854114 10.1093/jnci/91.17.1459 10.1369/0022155414545224 10.1038/s41598-017-08935-6 10.1023/A:1012748718150 10.1113/EP088147 10.2337/dc14-2441 10.3389/fphar.2017.00341 10.1182/blood-2004-02-0701 10.1210/jc.2002-021688 10.1124/jpet.105.092122 10.1002/1521-4141(200105)31:5<1544::AID-IMMU1544>3.0.CO;2-I 10.1158/1055-9965.EPI-20-1390 10.1095/biolreprod.114.120063 10.1034/j.1600-065X.2000.00618.x 10.1161/01.ATV.0000201938.78044.75 10.1210/en.2007-0168 10.17219/acem/59380 10.1016/j.mce.2010.08.002 10.1016/j.fertnstert.2015.07.392 10.3390/antiox10010022 10.1371/journal.pone.0183659 10.1186/s13048-015-0192-9 10.1111/j.1600-0897.1997.tb00192.x 10.1073/pnas.0611514104 10.1186/1477-7827-12-3 10.1034/j.1600-065X.2003.00073.x 10.1159/000507441 10.1177/1933719114542011 10.1093/humrep/dez104 10.1136/jitc-2020-001136 10.1016/j.fsi.2013.10.011 10.7150/jca.26133 10.1016/0026-0495(94)90209-7 10.3109/09513590.2010.508852 10.1093/biolre/ioaa141 |
| ContentType | Journal Article |
| Copyright | 2022 Elsevier B.V. Copyright © 2022 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2022 Elsevier B.V. – notice: Copyright © 2022 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION 7X8 7S9 L.6 |
| DOI | 10.1016/j.mce.2022.111730 |
| DatabaseName | CrossRef MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic AGRICOLA |
| Database_xml | – sequence: 1 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1872-8057 |
| ExternalDocumentID | 10_1016_j_mce_2022_111730 S0303720722001782 |
| GroupedDBID | --- --K --M -~X .~1 0R~ 123 1B1 1RT 1~. 1~5 4.4 457 4G. 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABBQC ABFRF ABGSF ABJNI ABLVK ABMAC ABMZM ABUDA ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV CS3 DOVZS DU5 EBS EFJIC EFLBG EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KOM LCYCR LX3 LZ1 M29 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 ROL RPZ SCC SCU SDF SDG SDP SES SPCBC SSH SSU SSZ T5K WH7 ~G- .55 .GJ 29M 3O- 53G 9DU AAHBH AAQXK AATTM AAXKI AAYWO AAYXX ABFNM ABWVN ABXDB ACIEU ACLOT ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AGRDE AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN CITATION EFKBS EJD FEDTE FGOYB G-2 HDZ HLW HMK HMO HVGLF HZ~ J5H MVM R2- SAE SBG SEW WUQ X7M ZGI ZXP ~HD 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c363t-6e8d6b0f11c7032534c7b3ef145ac4c7ea48330d935391df7f23a396c97c96543 |
| ISICitedReferencesCount | 11 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000844332700005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0303-7207 1872-8057 |
| IngestDate | Sat Sep 27 23:52:46 EDT 2025 Mon Sep 29 05:37:13 EDT 2025 Sat Nov 29 07:21:19 EST 2025 Tue Nov 18 21:56:18 EST 2025 Fri Feb 23 02:40:35 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | CXCR5 Polycystic ovarian syndrome Inflammation Metformin Extracellular-signaling-related kinase CXCL13 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c363t-6e8d6b0f11c7032534c7b3ef145ac4c7ea48330d935391df7f23a396c97c96543 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PQID | 2698631041 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2718349292 proquest_miscellaneous_2698631041 crossref_citationtrail_10_1016_j_mce_2022_111730 crossref_primary_10_1016_j_mce_2022_111730 elsevier_sciencedirect_doi_10_1016_j_mce_2022_111730 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-10-01 2022-10-00 20221001 |
| PublicationDateYYYYMMDD | 2022-10-01 |
| PublicationDate_xml | – month: 10 year: 2022 text: 2022-10-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationTitle | Molecular and cellular endocrinology |
| PublicationYear | 2022 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Rocha, M.M, Barcellos, A S.A.Y., D.D.G, Bagnoli, N.M.D.F, Baracat (bib85) 2011; 27 Livak, Schmittgen (bib54) 2001; 408 Zhang, Cao, Zhang, Jiang, Gao (bib108) 2016; 13 Moschovakis, Bubke, Friedrichsen, Falk, Förster (bib64) 2017; 7 Tang, Lord, Rj, Yasmin, Ah (bib90) 2012 Wang, Zhao, Xu, Guo, Nie, Lei, Long, Liu, Wang, Zhang, Zhang, Li, Zhang, Yuan, Yue (bib102) 2019; 94 Gunn, Ngo, Ansel, Ekland, Cyster, Williams (bib28) 1998; 391 Kuscu, Koyuncu, Ö, Inan, TuÕlu, Karaer (bib44) 2002; 16 Morin-papunen, Rautio, Ruokonen, Hedberg, Puukka, Tapanainen, Obstetrics, Gynecology, R (bib62) 2003; 88 Olbrecht, Busschaert, Qian, Vanderstichele, Loverix, Gorp, Nieuwenhuysen, Han, Broeck, Coosemans (bib70) 2021; 13 Glidewell-Kenney, Hurley, Pfaff, Weiss, Levine, Jameson (bib24) 2007; 104 González, Nair, Daniels, Basal, Schimke, Blair (bib26) 2012; 97 Musso, Shawker, Cochran, Javor, Young, Gorden (bib66) 2005; 63 Inzucchi, Bergenstal, Buse, Diamant, Ferrannini, Nauck, Peters, Tsapas (bib34) 2015; 38 Bergheim, Luyendyk, Steele, Russell, Guo, Roth, Arteel (bib9) 2006; 316 Carlsen, Baekkevold, Morton, Haraldsen, Brandtzaeg (bib12) 2004; 104 Choi, Park, Wilson, Rosewell, Akin, Curry, Jo (bib14) 2017; 96 Velija-ašimi (bib99) 2013; 13 Mansfield, Galea, Brincat, Hole, Mason (bib59) 2003; 79 Qi, Yin, Gu, Liu, Sun, Cao, Yan, Yuan, Wu (bib78) 2021; 86 Sortino, Salomone, Carruba, Drago, Rogol (bib89) 2017; 8 Harris, Terry (bib29) 2016; 2 Velez, Seldin, Motta (bib98) 2021; 104 Repaci, Gambineri, Pasquali (bib81) 2011; 335 Pokharel, Peippo, Weldenegodguad, Honkatukia, Li, Kantanen (bib76) 2020; 415 Amato, Conte, Mazziotti, Lalli, Vitolo, Tucker, Bellastella, Carella, Izzo (bib4) 2003; 101 Marshall (bib60) 2001; 3 Bednarska, Siejka (bib7) 2017; 26 Chen, He, Wang (bib13) 2020 Pau, Keefe, Duran, Welt (bib73) 2014; 99 Terranova, Montgomery Rice (bib91) 1997; 37 Mannerås, Cajander, Holma, Seleskovic, Lystig, Lo, Stener-victorin (bib58) 2014; 148 Isoda, Young, Zirlik, Macfarlane, Tsuboi, Gerdes, Scho, Libby (bib35) 2006; 26 Yang, Hur, Yoon, Jung, Lim, Ko (bib106) 2020; 85 Wood, Strauss (bib104) 2002; 3 Kyei, Sobhani, Nekonam, Shabani, Ebrahimi, Qasemi, Salahi, Fardin (bib46) 2020; vol. 6 Ullah, Wang, Yang, Appiah, Czika, Sah, Feng (bib95) 2021 Lepen Pleić, Secombes, Bird, Mladineo (bib51) 2014; 36 Jahrling, Hernandez, Denner, Dineley (bib36) 2014; 34 Guan, Wang, Bu, Zhao, Wang (bib27) 2020 Ukita, Ueno, Mandai (bib94) 2022; 10 Meng, Wu, Zhao, Tao, Chit, Zhang, Wang, Teerds (bib61) 2020; 10 Palomba, Falbo, Sala (bib72) 2014; 12 Karuputhula, Chattopadhyay, Chaudhury (bib42) 2013; 59 Waleed, Smi, Omnia, Pi (bib101) 2020; 1 Jiang, Ding, Wang, Yu, Hua, Chen, Ma, Chen (bib38) 2020; 85 Singh, Grizzle, Singh, James Lillard (bib88) 2012; 188 Ebrahimi, Rostami, Nekoonam, Rashidi, Sobhani, Amidi (bib18) 2021; 10 Raman, Wang, Troncone, Khan (bib79) 2015 Ignacio, Lee, Wilson, Beeghly-fadiel, Whalen, Son, Son, Son (bib33) 2018; 18 Myers, Britt, Wreford, Ebling, Kerr (bib67) 2004; 127 Rawson (bib80) 1991; 36 Li, Ma, Sheng, Xiao (bib52) 2021; 19 Lee, Anderson, Lee (bib49) 1991; 213 Sander, Luchetti, Solano, Elia, Di Girolamo, Gonzalez, Motta (bib86) 2006; 131 Gong, Zhu, Pang, Ai (bib25) 2017; 7 Tessaro, Modina, Franciosi, Sivelli, Terzaghi, Lodde, Luciano (bib92) 2015; 8 Adu-gyamfi, Tanam, Nelson, Czika, Kumar, Lamptey, Ding, Wang (bib3) 2020; 133 El-Haibi, Singh, Singh, Lillard J (bib19) 2011 Jungheim, Odibo (bib39) 2010; 94 Macut, Mladenović, Bjekić-Macut, Livadas, Stanojlović, Hrnčić, Rašić-Marković, Milutinović, Andrić (bib57) 2020; 16 Abdelrahman, Mahmoud, Fanous (bib1) 2021 Widney, Breen, Boscardin, Kitchen, Alcantar, Smith, Zack, Detels (bib103) 2005; 25 Zlotnik, Yoshie, Nomiyama (bib110) 2006; 7 Unosson, Dick, Bjarneg, Basso, Welander, Mani, Gotts, Wanhainen (bib96) 2020; 70 Lai, Jia, Yu, Zhang, Qiao, Guan, Kang (bib47) 2014; 91 Legler, Loetscher, Roos, Clark-Lewis, Baggiolini, Moser (bib50) 1998; 187 Fu, Xu, Fu, Wei, Liu, Liao, He, Wang, Chen, Lin, Li, Hong, Huang (bib23) 2020; 103 Karimzadeh, Eftekhar, Taheripanah, Tayebi, Sakhavat, Zare (bib40) 2007; 12 Lo, Mf, Let, Rb, Cr (bib55) 2020; 12 Seyam, Hasan, Khalifa, Ramadan, Hefzy (bib87) 2017; 33 Kitaya, Yasuo (bib43) 2010; 23 Lee, Park, Kang, Kawada, Yu, Han (bib48) 2009; 46 Tung, Garza, Lou, Bagavant (bib93) 2001; 8 Benrick, Chanclón, Micallef, Wu, Hadi, Shelton (bib8) 2017; 114 Czika, Yang, Yang, Adu-gyamfi, Ullah, Ruan, Chen, Wang, Wang, Ding (bib16) 2022 Naseri, Khazaei, Khazaei (bib68) 2021; 15 Adams, Liu, Ren, Wun, Zhou, Kenigsberg, Librach, Valdes, Gibbons, Richards (bib2) 2016; 101 Breitfeld, Ohl, Kremmer, Ellwart, Sallusto, Lipp, Förster (bib10) 2000; 192 Faure, Bertoldo, Khoueiry, Bongrani, Brion, Giulivi, Dupont, Froment (bib20) 2018; 9 Atef, Abd-ellatif, Emam, El, Amer, Hafez (bib5) 2019; 671 Franasiak, Burns, Slayden, Yuan, Fritz, Korach, Lessey, Young (bib21) 2015; 22 Karthik, Vipin, Kapoor, Tripathi, Shukla, Dabadghao (bib41) 2019; 34 Liu, Liu, Xiong, Wang, Liu, Yin, Tu, Wang, Xiang, Xu, Duan, Tao, Zhao, Mei (bib53) 2019; 80 Kusuyama, Bandow, Ohnishi, Amir, Shima, Semba, Matsuguchi (bib45) 2019; 476 Richards, Liu, Shimada (bib83) 2008; 19 Rickard, Ryan, Hall, De Graaf, Hermes (bib84) 2017; 12 Velazquez, Sosa, Glueck (bib97) 1994; 43 Zahoor, Shrivastava (bib107) 2022; 13 Morley, Tang, Yasmin, Norman, Balen (bib63) 2017; 11 Oztas, Ozler, Tokmak, Yilmaz, Danisman, Ergin, Yakut (bib71) 2015; 104 Ayaz, Alwan, Farooq (bib6) 2013; 6 Franks, Mason, Willis (bib22) 2000; 163 Cyster, Ansel, Reif, Ekland, Hyman, Tang, Luther, Ngo (bib15) 2000; 176 Henry, Kendall (bib30) 2010; 185 Müller, Höpken, Lipp (bib65) 2003; 195 Luo, Yang, Wang, Guo, Yue (bib56) 2019; 105 Bu, Niedermeier, Schmitt-gra, Wierda, Keating, Burger (bib11) 2019; 110 Peres, Townsend, Birmann, Conejo-garcia, Kim, Kubzansky, Magpantay, Martinez-maza, Tworoger (bib74) 2022; 30 Yang, Lu, Zhang, Wang, He, Xu, Xu, Liu (bib105) 2021; 9 Pietro, Parborell, Irusta, Pascuali, Bas, Bianchi, Tesone, Abramovich (bib75) 2015; 156 Ness, Cottreau (bib69) 1999; 91 Rezvanfar, Ahmadi, Saadi, Abdollahi (bib82) 2012; 31 Duleba, Dokras (bib17) 2012; 97 Hewitt, Baskin, Frevert, Stahl, Rosa-molinar (bib31) 2014; 62 Vissers, Hartgers, Lindhout, Figdor, Adema (bib100) 2001; 5 Zhou, Layton, Hong (bib109) 2018; 9 Jakimiuk, Weitsman, Navab, Magoffin (bib37) 2001; 86 Huang, Yu, Gao, Li, Zhang, Zhao, Zhao, Qiao (bib32) 2015; 10 Poretsky, Cataldo, Rosenwaks, Giudice (bib77) 1999; 4 Henry (10.1016/j.mce.2022.111730_bib30) 2010; 185 Mansfield (10.1016/j.mce.2022.111730_bib59) 2003; 79 Rocha (10.1016/j.mce.2022.111730_bib85) 2011; 27 Luo (10.1016/j.mce.2022.111730_bib56) 2019; 105 Qi (10.1016/j.mce.2022.111730_bib78) 2021; 86 Myers (10.1016/j.mce.2022.111730_bib67) 2004; 127 Oztas (10.1016/j.mce.2022.111730_bib71) 2015; 104 Lo (10.1016/j.mce.2022.111730_bib55) 2020; 12 Zhou (10.1016/j.mce.2022.111730_bib109) 2018; 9 Raman (10.1016/j.mce.2022.111730_bib79) 2015 Müller (10.1016/j.mce.2022.111730_bib65) 2003; 195 Zlotnik (10.1016/j.mce.2022.111730_bib110) 2006; 7 Livak (10.1016/j.mce.2022.111730_bib54) 2001; 408 Sander (10.1016/j.mce.2022.111730_bib86) 2006; 131 Bu (10.1016/j.mce.2022.111730_bib11) 2019; 110 Kuscu (10.1016/j.mce.2022.111730_bib44) 2002; 16 Olbrecht (10.1016/j.mce.2022.111730_bib70) 2021; 13 Tung (10.1016/j.mce.2022.111730_bib93) 2001; 8 Velija-ašimi (10.1016/j.mce.2022.111730_bib99) 2013; 13 Terranova (10.1016/j.mce.2022.111730_bib91) 1997; 37 Marshall (10.1016/j.mce.2022.111730_bib60) 2001; 3 Cyster (10.1016/j.mce.2022.111730_bib15) 2000; 176 Jakimiuk (10.1016/j.mce.2022.111730_bib37) 2001; 86 Fu (10.1016/j.mce.2022.111730_bib23) 2020; 103 Yang (10.1016/j.mce.2022.111730_bib106) 2020; 85 Zhang (10.1016/j.mce.2022.111730_bib108) 2016; 13 El-Haibi (10.1016/j.mce.2022.111730_bib19) 2011 Karuputhula (10.1016/j.mce.2022.111730_bib42) 2013; 59 Ignacio (10.1016/j.mce.2022.111730_bib33) 2018; 18 Singh (10.1016/j.mce.2022.111730_bib88) 2012; 188 Karimzadeh (10.1016/j.mce.2022.111730_bib40) 2007; 12 Kusuyama (10.1016/j.mce.2022.111730_bib45) 2019; 476 Liu (10.1016/j.mce.2022.111730_bib53) 2019; 80 Repaci (10.1016/j.mce.2022.111730_bib81) 2011; 335 Tessaro (10.1016/j.mce.2022.111730_bib92) 2015; 8 Amato (10.1016/j.mce.2022.111730_bib4) 2003; 101 Wang (10.1016/j.mce.2022.111730_bib102) 2019; 94 Atef (10.1016/j.mce.2022.111730_bib5) 2019; 671 Peres (10.1016/j.mce.2022.111730_bib74) 2022; 30 Ullah (10.1016/j.mce.2022.111730_bib95) 2021 Chen (10.1016/j.mce.2022.111730_bib13) 2020 Glidewell-Kenney (10.1016/j.mce.2022.111730_bib24) 2007; 104 Wood (10.1016/j.mce.2022.111730_bib104) 2002; 3 Jiang (10.1016/j.mce.2022.111730_bib38) 2020; 85 Velazquez (10.1016/j.mce.2022.111730_bib97) 1994; 43 Morin-papunen (10.1016/j.mce.2022.111730_bib62) 2003; 88 Richards (10.1016/j.mce.2022.111730_bib83) 2008; 19 Faure (10.1016/j.mce.2022.111730_bib20) 2018; 9 Harris (10.1016/j.mce.2022.111730_bib29) 2016; 2 Rickard (10.1016/j.mce.2022.111730_bib84) 2017; 12 Palomba (10.1016/j.mce.2022.111730_bib72) 2014; 12 Ebrahimi (10.1016/j.mce.2022.111730_bib18) 2021; 10 Lee (10.1016/j.mce.2022.111730_bib49) 1991; 213 Gunn (10.1016/j.mce.2022.111730_bib28) 1998; 391 Mannerås (10.1016/j.mce.2022.111730_bib58) 2014; 148 Adams (10.1016/j.mce.2022.111730_bib2) 2016; 101 Ayaz (10.1016/j.mce.2022.111730_bib6) 2013; 6 Lepen Pleić (10.1016/j.mce.2022.111730_bib51) 2014; 36 Widney (10.1016/j.mce.2022.111730_bib103) 2005; 25 Czika (10.1016/j.mce.2022.111730_bib16) 2022 Pau (10.1016/j.mce.2022.111730_bib73) 2014; 99 Sortino (10.1016/j.mce.2022.111730_bib89) 2017; 8 Naseri (10.1016/j.mce.2022.111730_bib68) 2021; 15 González (10.1016/j.mce.2022.111730_bib26) 2012; 97 Musso (10.1016/j.mce.2022.111730_bib66) 2005; 63 Huang (10.1016/j.mce.2022.111730_bib32) 2015; 10 Yang (10.1016/j.mce.2022.111730_bib105) 2021; 9 Duleba (10.1016/j.mce.2022.111730_bib17) 2012; 97 Velez (10.1016/j.mce.2022.111730_bib98) 2021; 104 Pokharel (10.1016/j.mce.2022.111730_bib76) 2020; 415 Seyam (10.1016/j.mce.2022.111730_bib87) 2017; 33 Tang (10.1016/j.mce.2022.111730_bib90) 2012 Jahrling (10.1016/j.mce.2022.111730_bib36) 2014; 34 Breitfeld (10.1016/j.mce.2022.111730_bib10) 2000; 192 Adu-gyamfi (10.1016/j.mce.2022.111730_bib3) 2020; 133 Pietro (10.1016/j.mce.2022.111730_bib75) 2015; 156 Bednarska (10.1016/j.mce.2022.111730_bib7) 2017; 26 Morley (10.1016/j.mce.2022.111730_bib63) 2017; 11 Ukita (10.1016/j.mce.2022.111730_bib94) 2022; 10 Zahoor (10.1016/j.mce.2022.111730_bib107) 2022; 13 Rezvanfar (10.1016/j.mce.2022.111730_bib82) 2012; 31 Inzucchi (10.1016/j.mce.2022.111730_bib34) 2015; 38 Vissers (10.1016/j.mce.2022.111730_bib100) 2001; 5 Benrick (10.1016/j.mce.2022.111730_bib8) 2017; 114 Carlsen (10.1016/j.mce.2022.111730_bib12) 2004; 104 Jungheim (10.1016/j.mce.2022.111730_bib39) 2010; 94 Li (10.1016/j.mce.2022.111730_bib52) 2021; 19 Hewitt (10.1016/j.mce.2022.111730_bib31) 2014; 62 Franks (10.1016/j.mce.2022.111730_bib22) 2000; 163 Karthik (10.1016/j.mce.2022.111730_bib41) 2019; 34 Isoda (10.1016/j.mce.2022.111730_bib35) 2006; 26 Unosson (10.1016/j.mce.2022.111730_bib96) 2020; 70 Choi (10.1016/j.mce.2022.111730_bib14) 2017; 96 Kyei (10.1016/j.mce.2022.111730_bib46) 2020; vol. 6 Waleed (10.1016/j.mce.2022.111730_bib101) 2020; 1 Lee (10.1016/j.mce.2022.111730_bib48) 2009; 46 Franasiak (10.1016/j.mce.2022.111730_bib21) 2015; 22 Ness (10.1016/j.mce.2022.111730_bib69) 1999; 91 Kitaya (10.1016/j.mce.2022.111730_bib43) 2010; 23 Guan (10.1016/j.mce.2022.111730_bib27) 2020 Macut (10.1016/j.mce.2022.111730_bib57) 2020; 16 Gong (10.1016/j.mce.2022.111730_bib25) 2017; 7 Poretsky (10.1016/j.mce.2022.111730_bib77) 1999; 4 Abdelrahman (10.1016/j.mce.2022.111730_bib1) 2021 Bergheim (10.1016/j.mce.2022.111730_bib9) 2006; 316 Meng (10.1016/j.mce.2022.111730_bib61) 2020; 10 Rawson (10.1016/j.mce.2022.111730_bib80) 1991; 36 Moschovakis (10.1016/j.mce.2022.111730_bib64) 2017; 7 Lai (10.1016/j.mce.2022.111730_bib47) 2014; 91 Legler (10.1016/j.mce.2022.111730_bib50) 1998; 187 |
| References_xml | – volume: 4 start-page: 535 year: 1999 end-page: 582 ident: bib77 article-title: The insulin-related ovarian regulatory system in health and disease publication-title: Endocr. Rev. – volume: 19 start-page: 191 year: 2008 end-page: 196 ident: bib83 article-title: Immune-like mechanisms in ovulation publication-title: Cell press – volume: 80 start-page: 1 year: 2019 end-page: 53 ident: bib53 article-title: CXCL13/CXCR5 signaling contributes to diabetes-induced tactile allodynia via activating pERK, pSTAT3, pAKT pathways and pro-inflammatory cytokines production in the spinal cord of male mice publication-title: Brain Behav. Immun. – volume: 96 start-page: 1256 year: 2017 end-page: 1266 ident: bib14 article-title: The expression of CXCR4 is induced by the luteinizing hormone surge and mediated by progesterone receptors in human preovulatory granulosa cells † om publication-title: Biol. Reprod. – volume: 34 start-page: 4054 year: 2014 end-page: 4063 ident: bib36 article-title: PPARγ recruitment to active ERK during memory consolidation is required for alzheimer ’s disease-related cognitive enhancement publication-title: Cellular/Mol. – volume: 13 start-page: 180 year: 2013 end-page: 185 ident: bib99 article-title: Evaluation of endocrine changes in women with the polycystic ovary syndrome during metformin treatment publication-title: Clin. Endocrinol, Diabetes Metab. Dis. – volume: 25 start-page: 702 year: 2005 end-page: 706 ident: bib103 article-title: Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection publication-title: J. Interferon Cytokine Res. – volume: 5 start-page: 1544 year: 2001 end-page: 1549 ident: bib100 article-title: BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo publication-title: Eur. J. Immunol. – volume: 335 start-page: 30 year: 2011 end-page: 41 ident: bib81 article-title: The role of low-grade inflammation in the polycystic ovary syndrome publication-title: Mol. Cell. Endocrinol. – volume: 6 start-page: 199 year: 2013 end-page: 201 ident: bib6 article-title: Efficacy of combined metformin-clomiphene citrate in comparison with clomiphene citrate alone in infertile women with polycystic ovarian syndrome (PCOS) publication-title: J. Med. life – volume: 114 start-page: 1 year: 2017 end-page: 10 ident: bib8 article-title: Adiponectin protects against development of metabolic disturbances in a PCOS mouse model publication-title: Proc. Natl. Acad. Sci. USA – volume: 36 start-page: 98 year: 2014 end-page: 112 ident: bib51 article-title: Characterization of three pro-inflammatory cytokines, TNFα1, TNFα2 and IL-1β, in cage-reared Atlantic bluefin tuna Thunnus thynnus publication-title: Fish Shellfish Immunol. – volume: 97 start-page: 7 year: 2012 end-page: 12 ident: bib17 article-title: Is PCOS an inflammatory process? publication-title: Fertil. Steril. – volume: 38 start-page: 140 year: 2015 end-page: 149 ident: bib34 article-title: Management of hyperglycemia in type 2 diabetes , 2015 : a patient- centered approach update to a position statement of the American diabetes association and the European association for the study of publication-title: Diabetes Care – volume: 12 start-page: 1 year: 2017 end-page: 18 ident: bib84 article-title: Using transrectal ultrasound to examine the effect of exogenous progesterone on early embryonic loss in sheep publication-title: PLoS One – volume: 156 start-page: 1453 year: 2015 end-page: 1463 ident: bib75 article-title: Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model publication-title: Reprod-Dev. – volume: 30 start-page: 710 year: 2022 end-page: 718 ident: bib74 article-title: Circulating biomarkers of inflammation and ovarian cancer risk in the Nurses' Health Studies publication-title: Cancer Epidemiol. Biomarkers Prev. – volume: 22 start-page: 442 year: 2015 end-page: 451 ident: bib21 article-title: Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and rhesus macaques with endometriosis publication-title: Reprod. Sci. – volume: 97 start-page: 2836 year: 2012 end-page: 2843 ident: bib26 article-title: Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women publication-title: J. Clin. Endocrinol. Metab. – volume: 415 start-page: 1 year: 2020 end-page: 19 ident: bib76 article-title: Gene expression profiling of corpus luteum reveals important insights about early pregnancy in domestic sheep publication-title: Genes – volume: 131 start-page: 591 year: 2006 end-page: 602 ident: bib86 article-title: Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone publication-title: Reproduction – volume: 101 start-page: 1177 year: 2003 end-page: 1182 ident: bib4 article-title: Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles publication-title: Obstet. Gynecol. – volume: 79 start-page: 956 year: 2003 end-page: 962 ident: bib59 article-title: Metformin has direct effects on human ovarian steroidogenesis publication-title: Fertil. Steril. – volume: 187 start-page: 655 year: 1998 end-page: 660 ident: bib50 article-title: B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5 publication-title: J. Exp. Med. – volume: 88 start-page: 4649 year: 2003 end-page: 4654 ident: bib62 article-title: Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome publication-title: J. Clin. Endocrinol. Metab. – volume: 13 start-page: 1 year: 2022 end-page: 10 ident: bib107 article-title: Turmeric extract alleviates endocrine-metabolic disturbances in letrozole-induced PCOS by increasing adiponectin circulation : a comparison with Metformin publication-title: Metab. Open. – volume: 2 start-page: 1 year: 2016 end-page: 9 ident: bib29 article-title: Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review publication-title: Fertility Res. Pract. – volume: 391 start-page: 799 year: 1998 end-page: 803 ident: bib28 article-title: A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1 publication-title: Nature – volume: 26 start-page: 611 year: 2006 end-page: 617 ident: bib35 article-title: Metformin inhibits proinflammatory responses and nuclear factor- kB in human vascular wall cells publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 7 start-page: 1 year: 2006 end-page: 11 ident: bib110 article-title: The chemokine and chemokine receptor superfamilies and their molecular evolution publication-title: Genome Biol. – volume: 91 start-page: 1459 year: 1999 end-page: 1467 ident: bib69 article-title: Possible role of ovarian epithelial inflammation in ovarian cancer publication-title: J. Natl. Cancer Inst. – volume: 94 start-page: 47 year: 2019 end-page: 58 ident: bib102 article-title: Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome publication-title: Metabolism – volume: 133 start-page: 1 year: 2020 end-page: 12 ident: bib3 article-title: Cytokine Activin and inhibin signaling : from regulation of physiology to involvement in the pathology of the female reproductive system publication-title: Cytokine – volume: 37 start-page: 50 year: 1997 end-page: 63 ident: bib91 article-title: Review: cytokine involvement in ovarian processes publication-title: Am. J. Reprod. Immunol. – volume: 7 start-page: 1 year: 2017 end-page: 13 ident: bib64 article-title: T cell specific Cxcr5 deficiency prevents rheumatoid arthritis publication-title: Sci. Rep. – volume: 110 start-page: 3316 year: 2019 end-page: 3326 ident: bib11 article-title: Overexpression of the CXCR5 chemokine receptor , and its ligand , CXCL13 in B-cell chronic lymphocytic leukemia publication-title: Blood – volume: 16 start-page: 55 year: 2020 end-page: 60 ident: bib57 article-title: Hypertension in polycystic ovary syndrome: novel insights publication-title: Curr. Hypertens. Rev. – volume: 99 start-page: 1870 year: 2014 end-page: 1878 ident: bib73 article-title: Metformin improves glucose effectiveness , not insulin sensitivity : predicting treatment response in women with polycystic ovary syndrome in an publication-title: Endocr. Res. – volume: 188 year: 2012 ident: bib88 article-title: Expression and histopathological correlation of CXCR5 and its natural ligand CXCL13 in ovarian cancer publication-title: J. Immunol. – start-page: 311 year: 2011 end-page: 319 ident: bib19 article-title: CXCL13 Mediates Prostate Cancer Cell Proliferation through JNK Signalling and Invasion through ERK Activation – volume: 13 start-page: 1 year: 2016 end-page: 13 ident: bib108 article-title: Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice publication-title: J. Neuroinflammation – volume: 104 start-page: e127 year: 2015 ident: bib71 article-title: Increased granzyme B levels are associated with insulin resistance in adolescent polycystic ovary patients publication-title: Fertil. Steril. – volume: 103 start-page: 1 year: 2020 end-page: 14 ident: bib23 article-title: Pachymic acid protects oocyte by improving the ovarian microenvironment in Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice publication-title: Biol. Reprod. – volume: 34 start-page: 1559 year: 2019 end-page: 1566 ident: bib41 article-title: Cardiovascular disease risk in the siblings of women with polycystic ovary syndrome publication-title: Hum. Reprod. – volume: 195 start-page: 117 year: 2003 end-page: 135 ident: bib65 article-title: The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity publication-title: Immunol. Rev. – volume: 19 start-page: 1 year: 2021 end-page: 16 ident: bib52 article-title: Screening of CXC chemokines in the microenvironment of ovarian cancer and the biological function of CXCL10 publication-title: World J. Surg. Oncol. – volume: 671 start-page: 245 year: 2019 end-page: 254 ident: bib5 article-title: Therapeutic potential of selenium in letrozole induced polycystic ovary syndrome rat model: targeting mitochondrial approach publication-title: Arch. Biochem. Biophys. – volume: 11 start-page: 1 year: 2017 end-page: 158 ident: bib63 article-title: Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility (Review) publication-title: Cochrane Database Syst. Rev. – volume: 12 start-page: 174 year: 2007 end-page: 178 ident: bib40 article-title: The effect of administration of metformin on lipid profile changes and insulin resistance in patients with polycystic ovary syndrome publication-title: Middle East Fertil. Soc. J. – volume: 104 start-page: 3021 year: 2004 end-page: 3027 ident: bib12 article-title: Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis publication-title: Blood – volume: 63 start-page: 73 year: 2005 end-page: 78 ident: bib66 article-title: Clinical evidence that hyperinsulinaemia independent of gonadotropins stimulates ovarian growth publication-title: Clin. Endocrinol. – volume: 148 start-page: 3781 year: 2014 end-page: 3791 ident: bib58 article-title: A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome publication-title: Endocrinology – volume: 70 start-page: 425 year: 2020 end-page: 433 ident: bib96 article-title: Metformin prescription associated with reduced abdominal aortic aneurysm growth rate and reduced chemokine expression in a Swedish cohort publication-title: Ann. Vasc. Surg. – volume: 104 start-page: 1205 year: 2021 end-page: 1217 ident: bib98 article-title: Inflammation and reproductive function in women with polycystic ovary syndrome publication-title: Biol. Reprod. – volume: 16 start-page: 361 year: 2002 end-page: 364 ident: bib44 article-title: Insulin : does it induce follicular arrest in the rat ovary publication-title: Gynecol. Endocrinol. – volume: 8 start-page: 1 year: 2017 end-page: 13 ident: bib89 article-title: Polycystic ovary syndrome : insights into the therapeutic approach with inositols publication-title: Front. Pharmacol. – volume: 163 start-page: 49 year: 2000 end-page: 52 ident: bib22 article-title: Follicular dynamics in the polycystic ovary syndrome publication-title: Mol. Cell. Endocrinol. – volume: 9 start-page: 3016 year: 2018 end-page: 3022 ident: bib109 article-title: Identification of genes and pathways involved in ovarian epithelial cancer by bioinformatics analysis publication-title: J. Cancer – volume: 18 start-page: 1 year: 2018 end-page: 14 ident: bib33 article-title: Obesity-induced peritoneal dissemination of ovarian cancer and dominant recruitment of macrophages in ascites publication-title: Immun. Net. – volume: 7 start-page: 5931 year: 2017 end-page: 5941 ident: bib25 article-title: Increased levels of CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells, and associated factors Bcl-6, CXCR5, IL-21 and IL-6 contribute to repeated implantation failure publication-title: Exp. Ther. Med. – volume: 26 start-page: 359 year: 2017 end-page: 367 ident: bib7 article-title: The pathogenesis and treatment of polycystic ovary syndrome : what's new publication-title: Adv. Clin. Exp. Med. – volume: 3 start-page: 272 year: 2001 end-page: 292 ident: bib60 article-title: Polycystic ovary syndrome: clinical considerations publication-title: Alternative Med. Rev. : J. Clin. Therapeutic. – volume: 43 start-page: 647 year: 1994 end-page: 654 ident: bib97 article-title: Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy publication-title: Metabolism – volume: 10 start-page: 1 year: 2015 end-page: 18 ident: bib32 article-title: Impaired oocyte quality induced by dehydroepiandrosterone is partially rescued by metformin treatment publication-title: PLoS One – volume: 15 start-page: 101 year: 2021 end-page: 107 ident: bib68 article-title: Potential therapeutic effect of bee pollen and metformin combination on testosterone and estradiol levels, apoptotic markers and total antioxidant capacity in A rat model of polycystic ovary syndrome publication-title: Int. J. Fertility Sterility. – volume: 36 start-page: 513 year: 1991 end-page: 515 ident: bib80 article-title: Prevalence of endometriosis in asymptomatic women publication-title: Reprod Med – start-page: 1 year: 2021 end-page: 12 ident: bib1 article-title: Impact of erythropoietin and myoinositol versus metformin on insulin resistance in a rat model of polycystic ovary syndrome publication-title: Arch. Physiol. Biochem. – volume: 27 start-page: 814 year: 2011 end-page: 819 ident: bib85 article-title: Dyslipidemia in women with polycystic ovary syndrome : incidence , pattern and predictors publication-title: Gynecol. Endocrinol. – volume: 1 start-page: 1 year: 2020 end-page: 14 ident: bib101 article-title: Differential effects of high fat diet-induced obesity on oocyte mitochondrial functions in inbred and outbred mice publication-title: Sci. Rep. – volume: 185 start-page: 1 year: 2010 end-page: 16 ident: bib30 article-title: CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice publication-title: J. Immunol. – volume: 23 start-page: 1136 year: 2010 end-page: 1146 ident: bib43 article-title: Aberrant expression of selectin E , CXCL1 , and CXCL13 in chronic endometritis publication-title: Mod. Pathol. – volume: 213 start-page: 185 year: 1991 end-page: 192 ident: bib49 article-title: Changes in ovarian morphology and serum hormones in the rat after treatment with dehydroepiandrosterone publication-title: Anat. Rec. – start-page: 1 year: 2021 end-page: 12 ident: bib95 article-title: Ovarian inflammatory mRNA profiles of a dehydroepiandrosterone plus high-fat diet-induced polycystic ovary syndrome mouse model publication-title: Reprod. Biomed. Online – volume: 12 start-page: 1 year: 2014 end-page: 15 ident: bib72 article-title: Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome : a systematic review with meta-analysis of randomized controlled trials publication-title: Reprod. Biol. Endocrinol. – volume: 86 start-page: 155 year: 2021 end-page: 161 ident: bib78 article-title: Elevated circulating levels of carnal ENST00000550337.1 are associated with polycystic ovary syndrome in Chinese women publication-title: Gynecol. Obstet. Invest. – volume: vol. 6 start-page: 1 year: 2020 end-page: 14 ident: bib46 publication-title: Assessing the Effect of MitoQ10 and Vitamin D3 on Ovarian Oxidative Stress, Steroidogenesis and Histomorphology in DHEA Induced PCOS Mouse Model – volume: 176 start-page: 181 year: 2000 end-page: 193 ident: bib15 article-title: Follicular stromal cells and lymphocyte homing to follicles publication-title: Immunol. Rev. – volume: 10 start-page: 1 year: 2022 end-page: 43 ident: bib94 article-title: CXCL13-producing CD4 + T cells accumulate in early phase of tertiary lymphoid structures in ovarian cancer publication-title: JCI Insight – volume: 10 start-page: 1 year: 2020 end-page: 17 ident: bib61 article-title: Transcriptome analysis of porcine granulosa cells in healthy and atretic follicles : role of steroidogenesis and oxidative stress publication-title: Antioxidants – volume: 10 start-page: 2807 year: 2021 end-page: 2815 ident: bib18 article-title: The effect of astaxanthin and metformin on oxidative stress in granulosa cells of BALB C mouse model of polycystic ovary syndrome publication-title: Reprod. Sci. – volume: 59 start-page: 91 year: 2013 end-page: 99 ident: bib42 article-title: Systems Biology in Reproductive Medicine Oxidative status in granulosa cells of infertile women undergoing IVF publication-title: Sys. Biol. Reprod. Med. ISSN – volume: 101 start-page: 3459 year: 2016 end-page: 3468 ident: bib2 article-title: Enhanced inflammatory transcriptome in the granulosa cells of women with polycystic ovarian syndrome publication-title: J. Clin. Endocrinol. Metab. – volume: 476 start-page: 3533 year: 2019 end-page: 3548 ident: bib45 article-title: CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction publication-title: Biochem. J. – volume: 127 start-page: 569 year: 2004 end-page: 580 ident: bib67 article-title: Methods for quantifying follicular numbers within the mouse ovary publication-title: Reproduction – volume: 62 start-page: 693 year: 2014 end-page: 697 ident: bib31 article-title: Controls for immunohistochemistry : the histochemical society's standards of practice for validation of immunohistochemical assays publication-title: J. Histochem. Cytochem. – volume: 8 start-page: 49 year: 2001 end-page: 51 ident: bib93 article-title: Autoimmune Ovarian Disease: mechanism of induction and prevention publication-title: Soc. Gynecologic Invest. – volume: 91 start-page: 1 year: 2014 end-page: 18 ident: bib47 article-title: High-fat diet induces significant metabolic disorders in a mouse model of polycystic ovary syndrome publication-title: Biol. Reprod. – volume: 86 start-page: 1318 year: 2001 end-page: 1323 ident: bib37 article-title: Luteinizing hormone receptor , steroidogenesis acute regulatory protein , and steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic ovaries publication-title: J. Clin. Endocrinol. Metab. – volume: 31 start-page: 887 year: 2012 end-page: 897 ident: bib82 article-title: Mechanistic links between oxidative/nitrosative stress and tumor necrosis factor alpha in letrozole-induced murine polycystic ovary: : biochemical and pathological evidences for beneficial effect of pioglitazone publication-title: Hum. Exp. Toxicol. – volume: 192 start-page: 1545 year: 2000 end-page: 1551 ident: bib10 article-title: Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production publication-title: J. Exp. Med. – year: 2020 ident: bib13 article-title: Effects of metformin on body weight in polycystic ovary syndrome patients: model-based meta- analysis publication-title: Expert Rev. Clin. Pharmacol. 0 – volume: 9 start-page: 1 year: 2021 end-page: 11 ident: bib105 article-title: CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in grade serous ovarian cancer high publication-title: J. ImmunoTher. Cancer – start-page: 1 year: 2015 end-page: 12 ident: bib79 article-title: Associated with a unique gene expression pattern publication-title: PL0S ONE – start-page: 1 year: 2020 end-page: 12 ident: bib27 article-title: The effect of metformin on polycystic ovary syndrome in overweight women : a systematic review and meta-analysis of randomized controlled trials publication-title: Int. J. Endocrinol. – volume: 85 start-page: 252 year: 2020 end-page: 258 ident: bib106 article-title: A comparison of embryonic development and clinical outcomes between in vitro oocytes maturation using micro-vibration system and in vivo oocytes maturation in polycystic ovarian syndrome patients publication-title: Gynecol. Obstet. Invest. – volume: 408 start-page: 402 year: 2001 end-page: 408 ident: bib54 article-title: Analysis of relative gene expression data using real- time quantitative PCR and the 2-ΔΔCT method publication-title: Methods – volume: 316 start-page: 1053 year: 2006 end-page: 1061 ident: bib9 article-title: Metformin prevents endotoxin-induced liver injury after partial hepatectomy publication-title: J. Pharmacol. Exp. Therapeut. – volume: 46 start-page: 160 year: 2009 end-page: 165 ident: bib48 article-title: Cytokine Chemokine and chemokine receptor gene expression in the mesenteric adipose tissue of KKAy mice publication-title: Cytokine – volume: 12 start-page: 1 year: 2020 end-page: 75 ident: bib55 article-title: Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome (Review) publication-title: Cochrane Database Syst. Rev. – volume: 33 start-page: 892 year: 2017 end-page: 898 ident: bib87 article-title: Evaluation of tumor necrosis factor alpha serum level in obese and lean women with clomiphene citrate-resistant polycystic ovary disease publication-title: Gynecol. Endocrinol. – volume: 105 start-page: 282 year: 2019 end-page: 292 ident: bib56 article-title: Hydroxysafflor yellow A exerts beneficial effects by restoring hormone secretion and alleviating oxidative stress in polycystic ovary syndrome mice publication-title: Exp. Physiol. – volume: 13 start-page: 1 year: 2021 end-page: 30 ident: bib70 article-title: High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing : specific cell subtypes influence survival and determine molecular subtype classification publication-title: Genome Med. – volume: 85 start-page: 167 year: 2020 end-page: 177 ident: bib38 article-title: Association of paraoxonase 1 gene polymorphisms and polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis publication-title: Gynecol. Obstet. Invest. – volume: 104 start-page: 8173 year: 2007 end-page: 8177 ident: bib24 article-title: Nonclassical estrogen receptor α signaling mediates negative feedback in the female mouse reproductive axis publication-title: Proc. Natl. Acad. Sci. USA – volume: 94 start-page: 2659 year: 2010 end-page: 2664 ident: bib39 article-title: Fertility treatment in women with polycystic ovary syndrome : a decision analysis of different oral ovulation induction agents publication-title: Fertil. Steril. – start-page: 1 year: 2022 end-page: 10 ident: bib16 article-title: A decrease in cluster of differentiation 2 expression on natural killer cells is associated with polycystic ovary syndrome but not influenced by metformin in a mouse model publication-title: Biol. Reprod. – volume: 3 start-page: 33 year: 2002 end-page: 46 ident: bib104 article-title: Multiple signal transduction pathways regulate ovarian steroidogenesis publication-title: Rev. Endocr. Metab. Disord. – volume: 8 start-page: 1 year: 2015 end-page: 13 ident: bib92 article-title: Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome publication-title: J. Ovarian Res. – year: 2012 ident: bib90 article-title: Pioglitazone , D-Chiro-Inositol) for Women with Polycystic Ovary Syndrome , Oligo Amenorrhoea and Subfertility (Review) – volume: 9 start-page: 1 year: 2018 end-page: 12 ident: bib20 article-title: Metformin in reproductive biology publication-title: Front. Endocrinol. – volume: 156 start-page: 1453 year: 2015 ident: 10.1016/j.mce.2022.111730_bib75 article-title: Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model publication-title: Reprod-Dev. – volume: 31 start-page: 887 year: 2012 ident: 10.1016/j.mce.2022.111730_bib82 article-title: Mechanistic links between oxidative/nitrosative stress and tumor necrosis factor alpha in letrozole-induced murine polycystic ovary: : biochemical and pathological evidences for beneficial effect of pioglitazone publication-title: Hum. Exp. Toxicol. doi: 10.1177/0960327111426589 – volume: 70 start-page: 425 year: 2020 ident: 10.1016/j.mce.2022.111730_bib96 article-title: Metformin prescription associated with reduced abdominal aortic aneurysm growth rate and reduced chemokine expression in a Swedish cohort publication-title: Ann. Vasc. Surg. doi: 10.1016/j.avsg.2020.06.039 – volume: 18 start-page: 1 year: 2018 ident: 10.1016/j.mce.2022.111730_bib33 article-title: Obesity-induced peritoneal dissemination of ovarian cancer and dominant recruitment of macrophages in ascites publication-title: Immun. Net. – volume: 36 start-page: 513 year: 1991 ident: 10.1016/j.mce.2022.111730_bib80 article-title: Prevalence of endometriosis in asymptomatic women publication-title: Reprod Med – volume: 213 start-page: 185 year: 1991 ident: 10.1016/j.mce.2022.111730_bib49 article-title: Changes in ovarian morphology and serum hormones in the rat after treatment with dehydroepiandrosterone publication-title: Anat. Rec. doi: 10.1002/ar.1092310206 – volume: 4 start-page: 535 year: 1999 ident: 10.1016/j.mce.2022.111730_bib77 article-title: The insulin-related ovarian regulatory system in health and disease publication-title: Endocr. Rev. doi: 10.1210/edrv.20.4.0374 – year: 2020 ident: 10.1016/j.mce.2022.111730_bib13 article-title: Effects of metformin on body weight in polycystic ovary syndrome patients: model-based meta- analysis publication-title: Expert Rev. Clin. Pharmacol. 0 – volume: 163 start-page: 49 year: 2000 ident: 10.1016/j.mce.2022.111730_bib22 article-title: Follicular dynamics in the polycystic ovary syndrome publication-title: Mol. Cell. Endocrinol. doi: 10.1016/S0303-7207(99)00239-7 – volume: 63 start-page: 73 year: 2005 ident: 10.1016/j.mce.2022.111730_bib66 article-title: Clinical evidence that hyperinsulinaemia independent of gonadotropins stimulates ovarian growth publication-title: Clin. Endocrinol. doi: 10.1111/j.1365-2265.2005.02302.x – volume: 185 start-page: 1 year: 2010 ident: 10.1016/j.mce.2022.111730_bib30 article-title: CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice publication-title: J. Immunol. doi: 10.4049/jimmunol.0903710 – volume: 19 start-page: 191 issue: 6 year: 2008 ident: 10.1016/j.mce.2022.111730_bib83 article-title: Immune-like mechanisms in ovulation publication-title: Cell press – volume: 415 start-page: 1 year: 2020 ident: 10.1016/j.mce.2022.111730_bib76 article-title: Gene expression profiling of corpus luteum reveals important insights about early pregnancy in domestic sheep publication-title: Genes – volume: 46 start-page: 160 year: 2009 ident: 10.1016/j.mce.2022.111730_bib48 article-title: Cytokine Chemokine and chemokine receptor gene expression in the mesenteric adipose tissue of KKAy mice publication-title: Cytokine doi: 10.1016/j.cyto.2008.12.025 – volume: 13 start-page: 1 year: 2016 ident: 10.1016/j.mce.2022.111730_bib108 article-title: Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice publication-title: J. Neuroinflammation doi: 10.1186/s12974-016-0652-1 – start-page: 311 year: 2011 ident: 10.1016/j.mce.2022.111730_bib19 – volume: 127 start-page: 569 year: 2004 ident: 10.1016/j.mce.2022.111730_bib67 article-title: Methods for quantifying follicular numbers within the mouse ovary publication-title: Reproduction doi: 10.1530/rep.1.00095 – volume: 13 start-page: 1 year: 2022 ident: 10.1016/j.mce.2022.111730_bib107 article-title: Turmeric extract alleviates endocrine-metabolic disturbances in letrozole-induced PCOS by increasing adiponectin circulation : a comparison with Metformin publication-title: Metab. Open. – volume: 476 start-page: 3533 year: 2019 ident: 10.1016/j.mce.2022.111730_bib45 article-title: CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction publication-title: Biochem. J. doi: 10.1042/BCJ20190709 – volume: 25 start-page: 702 year: 2005 ident: 10.1016/j.mce.2022.111730_bib103 article-title: Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection publication-title: J. Interferon Cytokine Res. doi: 10.1089/jir.2005.25.702 – volume: 80 start-page: 1 year: 2019 ident: 10.1016/j.mce.2022.111730_bib53 article-title: CXCL13/CXCR5 signaling contributes to diabetes-induced tactile allodynia via activating pERK, pSTAT3, pAKT pathways and pro-inflammatory cytokines production in the spinal cord of male mice publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2019.05.020 – volume: 97 start-page: 7 year: 2012 ident: 10.1016/j.mce.2022.111730_bib17 article-title: Is PCOS an inflammatory process? publication-title: Fertil. Steril. doi: 10.1016/j.fertnstert.2011.11.023 – volume: 99 start-page: 1870 year: 2014 ident: 10.1016/j.mce.2022.111730_bib73 article-title: Metformin improves glucose effectiveness , not insulin sensitivity : predicting treatment response in women with polycystic ovary syndrome in an publication-title: Endocr. Res. – start-page: 1 year: 2021 ident: 10.1016/j.mce.2022.111730_bib95 article-title: Ovarian inflammatory mRNA profiles of a dehydroepiandrosterone plus high-fat diet-induced polycystic ovary syndrome mouse model publication-title: Reprod. Biomed. Online – volume: 391 start-page: 799 year: 1998 ident: 10.1016/j.mce.2022.111730_bib28 article-title: A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1 publication-title: Nature doi: 10.1038/35876 – volume: 188 year: 2012 ident: 10.1016/j.mce.2022.111730_bib88 article-title: Expression and histopathological correlation of CXCR5 and its natural ligand CXCL13 in ovarian cancer publication-title: J. Immunol. doi: 10.4049/jimmunol.188.Supp.161.14 – volume: 110 start-page: 3316 year: 2019 ident: 10.1016/j.mce.2022.111730_bib11 article-title: Overexpression of the CXCR5 chemokine receptor , and its ligand , CXCL13 in B-cell chronic lymphocytic leukemia publication-title: Blood – volume: 96 start-page: 1256 year: 2017 ident: 10.1016/j.mce.2022.111730_bib14 article-title: The expression of CXCR4 is induced by the luteinizing hormone surge and mediated by progesterone receptors in human preovulatory granulosa cells † om publication-title: Biol. Reprod. doi: 10.1093/biolre/iox054 – volume: 85 start-page: 167 year: 2020 ident: 10.1016/j.mce.2022.111730_bib38 article-title: Association of paraoxonase 1 gene polymorphisms and polycystic ovarian syndrome susceptibility: a systematic review and meta-analysis publication-title: Gynecol. Obstet. Invest. doi: 10.1159/000505452 – volume: 10 start-page: 2807 year: 2021 ident: 10.1016/j.mce.2022.111730_bib18 article-title: The effect of astaxanthin and metformin on oxidative stress in granulosa cells of BALB C mouse model of polycystic ovary syndrome publication-title: Reprod. Sci. doi: 10.1007/s43032-021-00577-4 – volume: 13 start-page: 1 year: 2021 ident: 10.1016/j.mce.2022.111730_bib70 article-title: High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing : specific cell subtypes influence survival and determine molecular subtype classification publication-title: Genome Med. doi: 10.1186/s13073-021-00922-x – volume: 94 start-page: 2659 year: 2010 ident: 10.1016/j.mce.2022.111730_bib39 article-title: Fertility treatment in women with polycystic ovary syndrome : a decision analysis of different oral ovulation induction agents publication-title: Fertil. Steril. doi: 10.1016/j.fertnstert.2010.03.077 – volume: 9 start-page: 1 year: 2018 ident: 10.1016/j.mce.2022.111730_bib20 article-title: Metformin in reproductive biology publication-title: Front. Endocrinol. doi: 10.3389/fendo.2018.00675 – year: 2012 ident: 10.1016/j.mce.2022.111730_bib90 – volume: 79 start-page: 956 year: 2003 ident: 10.1016/j.mce.2022.111730_bib59 article-title: Metformin has direct effects on human ovarian steroidogenesis publication-title: Fertil. Steril. doi: 10.1016/S0015-0282(02)04925-7 – start-page: 1 year: 2020 ident: 10.1016/j.mce.2022.111730_bib27 article-title: The effect of metformin on polycystic ovary syndrome in overweight women : a systematic review and meta-analysis of randomized controlled trials publication-title: Int. J. Endocrinol. doi: 10.1155/2020/5150684 – volume: 33 start-page: 892 year: 2017 ident: 10.1016/j.mce.2022.111730_bib87 article-title: Evaluation of tumor necrosis factor alpha serum level in obese and lean women with clomiphene citrate-resistant polycystic ovary disease publication-title: Gynecol. Endocrinol. doi: 10.1080/09513590.2017.1320383 – volume: 16 start-page: 361 year: 2002 ident: 10.1016/j.mce.2022.111730_bib44 article-title: Insulin : does it induce follicular arrest in the rat ovary publication-title: Gynecol. Endocrinol. doi: 10.1080/gye.16.5.361.364 – volume: 187 start-page: 655 year: 1998 ident: 10.1016/j.mce.2022.111730_bib50 article-title: B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5 publication-title: J. Exp. Med. doi: 10.1084/jem.187.4.655 – volume: 131 start-page: 591 year: 2006 ident: 10.1016/j.mce.2022.111730_bib86 article-title: Role of the N, N′-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone publication-title: Reproduction doi: 10.1530/rep.1.00941 – volume: 23 start-page: 1136 year: 2010 ident: 10.1016/j.mce.2022.111730_bib43 article-title: Aberrant expression of selectin E , CXCL1 , and CXCL13 in chronic endometritis publication-title: Mod. Pathol. doi: 10.1038/modpathol.2010.98 – volume: 408 start-page: 402 year: 2001 ident: 10.1016/j.mce.2022.111730_bib54 article-title: Analysis of relative gene expression data using real- time quantitative PCR and the 2-ΔΔCT method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 97 start-page: 2836 year: 2012 ident: 10.1016/j.mce.2022.111730_bib26 article-title: Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2012-1259 – volume: 19 start-page: 1 year: 2021 ident: 10.1016/j.mce.2022.111730_bib52 article-title: Screening of CXC chemokines in the microenvironment of ovarian cancer and the biological function of CXCL10 publication-title: World J. Surg. Oncol. doi: 10.1186/s12957-021-02440-x – volume: 7 start-page: 1 year: 2006 ident: 10.1016/j.mce.2022.111730_bib110 article-title: The chemokine and chemokine receptor superfamilies and their molecular evolution publication-title: Genome Biol. doi: 10.1186/gb-2006-7-12-243 – volume: 8 start-page: 49 year: 2001 ident: 10.1016/j.mce.2022.111730_bib93 article-title: Autoimmune Ovarian Disease: mechanism of induction and prevention publication-title: Soc. Gynecologic Invest. – volume: 101 start-page: 3459 year: 2016 ident: 10.1016/j.mce.2022.111730_bib2 article-title: Enhanced inflammatory transcriptome in the granulosa cells of women with polycystic ovarian syndrome publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2015-4275 – start-page: 1 year: 2015 ident: 10.1016/j.mce.2022.111730_bib79 article-title: Associated with a unique gene expression pattern publication-title: PL0S ONE – volume: 59 start-page: 91 year: 2013 ident: 10.1016/j.mce.2022.111730_bib42 article-title: Systems Biology in Reproductive Medicine Oxidative status in granulosa cells of infertile women undergoing IVF publication-title: Sys. Biol. Reprod. Med. ISSN doi: 10.3109/19396368.2012.743197 – volume: 104 start-page: 1205 year: 2021 ident: 10.1016/j.mce.2022.111730_bib98 article-title: Inflammation and reproductive function in women with polycystic ovary syndrome publication-title: Biol. Reprod. doi: 10.1093/biolre/ioab050 – volume: 94 start-page: 47 year: 2019 ident: 10.1016/j.mce.2022.111730_bib102 article-title: Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome publication-title: Metabolism doi: 10.1016/j.metabol.2019.02.002 – volume: 192 start-page: 1545 year: 2000 ident: 10.1016/j.mce.2022.111730_bib10 article-title: Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production publication-title: J. Exp. Med. doi: 10.1084/jem.192.11.1545 – volume: vol. 6 start-page: 1 year: 2020 ident: 10.1016/j.mce.2022.111730_bib46 – volume: 133 start-page: 1 year: 2020 ident: 10.1016/j.mce.2022.111730_bib3 article-title: Cytokine Activin and inhibin signaling : from regulation of physiology to involvement in the pathology of the female reproductive system publication-title: Cytokine – volume: 671 start-page: 245 year: 2019 ident: 10.1016/j.mce.2022.111730_bib5 article-title: Therapeutic potential of selenium in letrozole induced polycystic ovary syndrome rat model: targeting mitochondrial approach publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2019.06.009 – volume: 86 start-page: 155 year: 2021 ident: 10.1016/j.mce.2022.111730_bib78 article-title: Elevated circulating levels of carnal ENST00000550337.1 are associated with polycystic ovary syndrome in Chinese women publication-title: Gynecol. Obstet. Invest. doi: 10.1159/000513671 – volume: 114 start-page: 1 year: 2017 ident: 10.1016/j.mce.2022.111730_bib8 article-title: Adiponectin protects against development of metabolic disturbances in a PCOS mouse model publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1708854114 – volume: 91 start-page: 1459 year: 1999 ident: 10.1016/j.mce.2022.111730_bib69 article-title: Possible role of ovarian epithelial inflammation in ovarian cancer publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/91.17.1459 – volume: 10 start-page: 1 year: 2022 ident: 10.1016/j.mce.2022.111730_bib94 article-title: CXCL13-producing CD4 + T cells accumulate in early phase of tertiary lymphoid structures in ovarian cancer publication-title: JCI Insight – volume: 62 start-page: 693 year: 2014 ident: 10.1016/j.mce.2022.111730_bib31 article-title: Controls for immunohistochemistry : the histochemical society's standards of practice for validation of immunohistochemical assays publication-title: J. Histochem. Cytochem. doi: 10.1369/0022155414545224 – volume: 7 start-page: 1 year: 2017 ident: 10.1016/j.mce.2022.111730_bib64 article-title: T cell specific Cxcr5 deficiency prevents rheumatoid arthritis publication-title: Sci. Rep. doi: 10.1038/s41598-017-08935-6 – volume: 3 start-page: 33 year: 2002 ident: 10.1016/j.mce.2022.111730_bib104 article-title: Multiple signal transduction pathways regulate ovarian steroidogenesis publication-title: Rev. Endocr. Metab. Disord. doi: 10.1023/A:1012748718150 – volume: 11 start-page: 1 year: 2017 ident: 10.1016/j.mce.2022.111730_bib63 article-title: Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility (Review) publication-title: Cochrane Database Syst. Rev. – volume: 105 start-page: 282 year: 2019 ident: 10.1016/j.mce.2022.111730_bib56 article-title: Hydroxysafflor yellow A exerts beneficial effects by restoring hormone secretion and alleviating oxidative stress in polycystic ovary syndrome mice publication-title: Exp. Physiol. doi: 10.1113/EP088147 – volume: 38 start-page: 140 year: 2015 ident: 10.1016/j.mce.2022.111730_bib34 article-title: Management of hyperglycemia in type 2 diabetes , 2015 : a patient- centered approach update to a position statement of the American diabetes association and the European association for the study of publication-title: Diabetes Care doi: 10.2337/dc14-2441 – volume: 8 start-page: 1 year: 2017 ident: 10.1016/j.mce.2022.111730_bib89 article-title: Polycystic ovary syndrome : insights into the therapeutic approach with inositols publication-title: Front. Pharmacol. doi: 10.3389/fphar.2017.00341 – volume: 104 start-page: 3021 year: 2004 ident: 10.1016/j.mce.2022.111730_bib12 article-title: Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis publication-title: Blood doi: 10.1182/blood-2004-02-0701 – volume: 12 start-page: 174 year: 2007 ident: 10.1016/j.mce.2022.111730_bib40 article-title: The effect of administration of metformin on lipid profile changes and insulin resistance in patients with polycystic ovary syndrome publication-title: Middle East Fertil. Soc. J. – volume: 88 start-page: 4649 year: 2003 ident: 10.1016/j.mce.2022.111730_bib62 article-title: Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2002-021688 – volume: 316 start-page: 1053 year: 2006 ident: 10.1016/j.mce.2022.111730_bib9 article-title: Metformin prevents endotoxin-induced liver injury after partial hepatectomy publication-title: J. Pharmacol. Exp. Therapeut. doi: 10.1124/jpet.105.092122 – volume: 5 start-page: 1544 year: 2001 ident: 10.1016/j.mce.2022.111730_bib100 article-title: BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo publication-title: Eur. J. Immunol. doi: 10.1002/1521-4141(200105)31:5<1544::AID-IMMU1544>3.0.CO;2-I – volume: 30 start-page: 710 year: 2022 ident: 10.1016/j.mce.2022.111730_bib74 article-title: Circulating biomarkers of inflammation and ovarian cancer risk in the Nurses' Health Studies publication-title: Cancer Epidemiol. Biomarkers Prev. doi: 10.1158/1055-9965.EPI-20-1390 – volume: 34 start-page: 4054 year: 2014 ident: 10.1016/j.mce.2022.111730_bib36 article-title: PPARγ recruitment to active ERK during memory consolidation is required for alzheimer ’s disease-related cognitive enhancement publication-title: Cellular/Mol. – volume: 91 start-page: 1 year: 2014 ident: 10.1016/j.mce.2022.111730_bib47 article-title: High-fat diet induces significant metabolic disorders in a mouse model of polycystic ovary syndrome publication-title: Biol. Reprod. doi: 10.1095/biolreprod.114.120063 – volume: 1 start-page: 1 year: 2020 ident: 10.1016/j.mce.2022.111730_bib101 article-title: Differential effects of high fat diet-induced obesity on oocyte mitochondrial functions in inbred and outbred mice publication-title: Sci. Rep. – volume: 176 start-page: 181 year: 2000 ident: 10.1016/j.mce.2022.111730_bib15 article-title: Follicular stromal cells and lymphocyte homing to follicles publication-title: Immunol. Rev. doi: 10.1034/j.1600-065X.2000.00618.x – volume: 86 start-page: 1318 year: 2001 ident: 10.1016/j.mce.2022.111730_bib37 article-title: Luteinizing hormone receptor , steroidogenesis acute regulatory protein , and steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic ovaries publication-title: J. Clin. Endocrinol. Metab. – volume: 26 start-page: 611 year: 2006 ident: 10.1016/j.mce.2022.111730_bib35 article-title: Metformin inhibits proinflammatory responses and nuclear factor- kB in human vascular wall cells publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.0000201938.78044.75 – start-page: 1 year: 2021 ident: 10.1016/j.mce.2022.111730_bib1 article-title: Impact of erythropoietin and myoinositol versus metformin on insulin resistance in a rat model of polycystic ovary syndrome publication-title: Arch. Physiol. Biochem. – volume: 2 start-page: 1 year: 2016 ident: 10.1016/j.mce.2022.111730_bib29 article-title: Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review publication-title: Fertility Res. Pract. – volume: 15 start-page: 101 year: 2021 ident: 10.1016/j.mce.2022.111730_bib68 article-title: Potential therapeutic effect of bee pollen and metformin combination on testosterone and estradiol levels, apoptotic markers and total antioxidant capacity in A rat model of polycystic ovary syndrome publication-title: Int. J. Fertility Sterility. – start-page: 1 year: 2022 ident: 10.1016/j.mce.2022.111730_bib16 article-title: A decrease in cluster of differentiation 2 expression on natural killer cells is associated with polycystic ovary syndrome but not influenced by metformin in a mouse model publication-title: Biol. Reprod. – volume: 148 start-page: 3781 year: 2014 ident: 10.1016/j.mce.2022.111730_bib58 article-title: A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome publication-title: Endocrinology doi: 10.1210/en.2007-0168 – volume: 26 start-page: 359 year: 2017 ident: 10.1016/j.mce.2022.111730_bib7 article-title: The pathogenesis and treatment of polycystic ovary syndrome : what's new publication-title: Adv. Clin. Exp. Med. doi: 10.17219/acem/59380 – volume: 335 start-page: 30 year: 2011 ident: 10.1016/j.mce.2022.111730_bib81 article-title: The role of low-grade inflammation in the polycystic ovary syndrome publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2010.08.002 – volume: 104 start-page: e127 year: 2015 ident: 10.1016/j.mce.2022.111730_bib71 article-title: Increased granzyme B levels are associated with insulin resistance in adolescent polycystic ovary patients publication-title: Fertil. Steril. doi: 10.1016/j.fertnstert.2015.07.392 – volume: 10 start-page: 1 year: 2020 ident: 10.1016/j.mce.2022.111730_bib61 article-title: Transcriptome analysis of porcine granulosa cells in healthy and atretic follicles : role of steroidogenesis and oxidative stress publication-title: Antioxidants doi: 10.3390/antiox10010022 – volume: 12 start-page: 1 year: 2017 ident: 10.1016/j.mce.2022.111730_bib84 article-title: Using transrectal ultrasound to examine the effect of exogenous progesterone on early embryonic loss in sheep publication-title: PLoS One doi: 10.1371/journal.pone.0183659 – volume: 8 start-page: 1 year: 2015 ident: 10.1016/j.mce.2022.111730_bib92 article-title: Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome publication-title: J. Ovarian Res. doi: 10.1186/s13048-015-0192-9 – volume: 16 start-page: 55 year: 2020 ident: 10.1016/j.mce.2022.111730_bib57 article-title: Hypertension in polycystic ovary syndrome: novel insights publication-title: Curr. Hypertens. Rev. – volume: 37 start-page: 50 year: 1997 ident: 10.1016/j.mce.2022.111730_bib91 article-title: Review: cytokine involvement in ovarian processes publication-title: Am. J. Reprod. Immunol. doi: 10.1111/j.1600-0897.1997.tb00192.x – volume: 6 start-page: 199 year: 2013 ident: 10.1016/j.mce.2022.111730_bib6 article-title: Efficacy of combined metformin-clomiphene citrate in comparison with clomiphene citrate alone in infertile women with polycystic ovarian syndrome (PCOS) publication-title: J. Med. life – volume: 104 start-page: 8173 year: 2007 ident: 10.1016/j.mce.2022.111730_bib24 article-title: Nonclassical estrogen receptor α signaling mediates negative feedback in the female mouse reproductive axis publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0611514104 – volume: 12 start-page: 1 year: 2014 ident: 10.1016/j.mce.2022.111730_bib72 article-title: Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome : a systematic review with meta-analysis of randomized controlled trials publication-title: Reprod. Biol. Endocrinol. doi: 10.1186/1477-7827-12-3 – volume: 3 start-page: 272 year: 2001 ident: 10.1016/j.mce.2022.111730_bib60 article-title: Polycystic ovary syndrome: clinical considerations publication-title: Alternative Med. Rev. : J. Clin. Therapeutic. – volume: 195 start-page: 117 year: 2003 ident: 10.1016/j.mce.2022.111730_bib65 article-title: The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity publication-title: Immunol. Rev. doi: 10.1034/j.1600-065X.2003.00073.x – volume: 13 start-page: 180 year: 2013 ident: 10.1016/j.mce.2022.111730_bib99 article-title: Evaluation of endocrine changes in women with the polycystic ovary syndrome during metformin treatment publication-title: Clin. Endocrinol, Diabetes Metab. Dis. – volume: 85 start-page: 252 year: 2020 ident: 10.1016/j.mce.2022.111730_bib106 article-title: A comparison of embryonic development and clinical outcomes between in vitro oocytes maturation using micro-vibration system and in vivo oocytes maturation in polycystic ovarian syndrome patients publication-title: Gynecol. Obstet. Invest. doi: 10.1159/000507441 – volume: 101 start-page: 1177 year: 2003 ident: 10.1016/j.mce.2022.111730_bib4 article-title: Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles publication-title: Obstet. Gynecol. – volume: 22 start-page: 442 year: 2015 ident: 10.1016/j.mce.2022.111730_bib21 article-title: Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and rhesus macaques with endometriosis publication-title: Reprod. Sci. doi: 10.1177/1933719114542011 – volume: 34 start-page: 1559 year: 2019 ident: 10.1016/j.mce.2022.111730_bib41 article-title: Cardiovascular disease risk in the siblings of women with polycystic ovary syndrome publication-title: Hum. Reprod. doi: 10.1093/humrep/dez104 – volume: 12 start-page: 1 year: 2020 ident: 10.1016/j.mce.2022.111730_bib55 article-title: Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome (Review) publication-title: Cochrane Database Syst. Rev. – volume: 9 start-page: 1 year: 2021 ident: 10.1016/j.mce.2022.111730_bib105 article-title: CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in grade serous ovarian cancer high publication-title: J. ImmunoTher. Cancer doi: 10.1136/jitc-2020-001136 – volume: 7 start-page: 5931 year: 2017 ident: 10.1016/j.mce.2022.111730_bib25 article-title: Increased levels of CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells, and associated factors Bcl-6, CXCR5, IL-21 and IL-6 contribute to repeated implantation failure publication-title: Exp. Ther. Med. – volume: 36 start-page: 98 year: 2014 ident: 10.1016/j.mce.2022.111730_bib51 article-title: Characterization of three pro-inflammatory cytokines, TNFα1, TNFα2 and IL-1β, in cage-reared Atlantic bluefin tuna Thunnus thynnus publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2013.10.011 – volume: 9 start-page: 3016 year: 2018 ident: 10.1016/j.mce.2022.111730_bib109 article-title: Identification of genes and pathways involved in ovarian epithelial cancer by bioinformatics analysis publication-title: J. Cancer doi: 10.7150/jca.26133 – volume: 10 start-page: 1 year: 2015 ident: 10.1016/j.mce.2022.111730_bib32 article-title: Impaired oocyte quality induced by dehydroepiandrosterone is partially rescued by metformin treatment publication-title: PLoS One – volume: 43 start-page: 647 year: 1994 ident: 10.1016/j.mce.2022.111730_bib97 article-title: Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy publication-title: Metabolism doi: 10.1016/0026-0495(94)90209-7 – volume: 27 start-page: 814 year: 2011 ident: 10.1016/j.mce.2022.111730_bib85 article-title: Dyslipidemia in women with polycystic ovary syndrome : incidence , pattern and predictors publication-title: Gynecol. Endocrinol. doi: 10.3109/09513590.2010.508852 – volume: 103 start-page: 1 year: 2020 ident: 10.1016/j.mce.2022.111730_bib23 article-title: Pachymic acid protects oocyte by improving the ovarian microenvironment in Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice publication-title: Biol. Reprod. doi: 10.1093/biolre/ioaa141 |
| SSID | ssj0007528 |
| Score | 2.439755 |
| Snippet | Polycystic ovary syndrome (PCOS) is becoming a common pathology among women, yet its pathogenesis remains enigmatic. The chemokine C-X-C motif ligand 13... |
| SourceID | proquest crossref elsevier |
| SourceType | Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 111730 |
| SubjectTerms | CXCL13 CXCR5 endocrinology Extracellular-signaling-related kinase Inflammation mechanism of action Metformin pathogenesis Polycystic ovarian syndrome polycystic ovary syndrome therapeutics |
| Title | CXCL13 and CXCR5 are upregulated in PCOS mice ovaries but downregulated following metformin administration |
| URI | https://dx.doi.org/10.1016/j.mce.2022.111730 https://www.proquest.com/docview/2698631041 https://www.proquest.com/docview/2718349292 |
| Volume | 556 |
| WOSCitedRecordID | wos000844332700005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: ScienceDirect database customDbUrl: eissn: 1872-8057 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0007528 issn: 0303-7207 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELe6DSFeEGwgxsdkJLQHoqAkTpz4sao6PtR1E7RS3iLXcbSUNildWra98K9zdr7WCarxwEvkRue06u-X8935fIfQO-5KSRMZm5YAd9VNODe54L6pSn9JTikjMdfNJvzhMAhDdt7p_KrPwqxnfpYFV1ds8V-hhnsAtjo6-w9wNw-FGzAG0OEKsMP1XsD3wt7AJnpTAIZfPUPldq0Wy7LpvFS1lozz3tk3QzWiN_K1dpaNyaowYvDIW7EEGJL_VJGEuSyUaQvz-Eap3duG7WndZrc8KCdnM_1BZnEOemkzeD8G6uloTneeZq1uXq75TRmkjnnS5hGszI_XfJ7orIN-losLZTmnbRi7d5N-L4PDy_pxVRQDHOA6H645vWUR03fKDri1ZvY8aiyUUgc1ZP5R35ehh-mHuVAlTx2nEm4Xt3pDf3gWnYwHg2jUD0fHix-majumtuerHiw7aM_xPQZqca_7uR9-aRZz39PteZufV2-M6xTBO9_6N9PmziKvLZfRE_S4cjlwt6TKU9SR2T466Ga8yOfX-BjrJGAN0D56eFrlWhygaUkkDHhiTSQMRMK3iITTDCsiYUUkXBEJA5HwBpFwQyTcEAlvEukZGp_0R71PZtWZwxSEksKkMojpxEpsW8CK4XjEFf6EyMR2PS5gLLkbEGLFjHiE2XHiJw7hhFHBfMHUaebnaDfLM_kC4diKaew4IOLaqpUDIzxgE2siwJKVgeMdIqv-UyNRla1X3VNmUZ2fOI0Ah0jhEJU4HKL3zZRFWbNlm7BbIxVVRmdpTEbAsW3T3taoRqCQ1WvFM5mvLiOHsoCC0-TaW2TAIlRlQZnz8h4yr9Cj9pV5jXaL5Uq-QQ_Eukgvl0doxw-Do4q3vwG5y7of |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CXCL13+and+CXCR5+are+upregulated+in+PCOS+mice+ovaries+but+downregulated+following+metformin+administration&rft.jtitle=Molecular+and+cellular+endocrinology&rft.au=Ullah%2C+Amin&rft.au=Pervaz%2C+Sadaf&rft.au=Adu-Gyamfi%2C+Enoch+Appiah&rft.au=Czika%2C+Armin&rft.date=2022-10-01&rft.issn=0303-7207&rft.volume=556+p.111730-&rft_id=info:doi/10.1016%2Fj.mce.2022.111730&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0303-7207&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0303-7207&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0303-7207&client=summon |