IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration

IL-22 is produced by activated T cells and signals through a receptor complex consisting of IL-22R1 and IL-10R2. The aim of this study was to analyze IL-22 receptor expression, signal transduction, and specific biological functions of this cytokine system in intestinal epithelial cells (IEC). Expres...

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Bibliographic Details

Published in:	American journal of physiology: Gastrointestinal and liver physiology Vol. 290; no. 4; p. G827
Main Authors:	Brand, Stephan, Beigel, Florian, Olszak, Torsten, Zitzmann, Kathrin, Eichhorst, Sören T, Otte, Jan-Michel, Diepolder, Helmut, Marquardt, Andreas, Jagla, Wolfgang, Popp, Andreas, Leclair, Stéphane, Herrmann, Karin, Seiderer, Julia, Ochsenkühn, Thomas, Göke, Burkhard, Auernhammer, Christoph J, Dambacher, Julia
Format:	Journal Article
Language:	English
Published:	United States 01.04.2006
Subjects:	Cell Movement Cells, Cultured Crohn Disease - immunology Crohn Disease - pathology Epithelial Cells - immunology Epithelial Cells - pathology Gene Expression Regulation - immunology Humans Inflammation - genetics Interleukin-22 Interleukins - immunology Intestinal Mucosa - immunology Intestinal Mucosa - pathology
ISSN:	0193-1857
Online Access:	Get more information
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