Mechanisms of vitamin D action in skeletal muscle

Vitamin D receptor expression and associated function have been reported in various muscle models, including C 2 C 12 , L6 cell lines and primary human skeletal muscle cells. It is believed that 1,25-hydroxyvitamin D 3 (1,25(OH) 2 D 3 ), the active form of vitamin D, has a direct regulatory role in...

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Bibliographic Details
Published in:Nutrition research reviews Vol. 32; no. 2; pp. 192 - 204
Main Authors: Montenegro, Karina Romeu, Cruzat, Vinicius, Carlessi, Rodrigo, Newsholme, Philip
Format: Journal Article
Language:English
Published: England Cambridge University Press 01.12.2019
Subjects:
Atrophy
Bioavailability
Bone density
Calciferol
Calcitriol
calcitriol receptors
Cardiovascular disease
cell communication
Cell culture
Cell differentiation
Cell lines
Cell proliferation
Cyclin-dependent kinases
Diet
Enzymes
Gene expression
gene expression regulation
Gene regulation
Genes
Genomics
Health care
Homeostasis
humans
Kinases
MAP kinase
Metabolism
Mitochondria
mitogen-activated protein kinase
Molecular modelling
muscle development
muscle fibers
Muscle function
Muscle strength
Muscles
Musculoskeletal system
myocytes
Myogenesis
Osteoporosis
pain
Protein biosynthesis
Protein kinase
Protein synthesis
Protein turnover
Proteins
Receptors
risk
Sarcopenia
Signal transduction
Signaling
Skeletal muscle
Transcription
transcription (genetics)
Transcription factors
Vitamin D
Vitamin deficiency
Mitochondria
Muscle
Protein synthesis
Myogenesis
Calcitriol
ISSN:0954-4224, 1475-2700, 1475-2700
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Summary:Vitamin D receptor expression and associated function have been reported in various muscle models, including C 2 C 12 , L6 cell lines and primary human skeletal muscle cells. It is believed that 1,25-hydroxyvitamin D 3 (1,25(OH) 2 D 3 ), the active form of vitamin D, has a direct regulatory role in skeletal muscle function, where it participates in myogenesis, cell proliferation, differentiation, regulation of protein synthesis and mitochondrial metabolism through activation of various cellular signalling cascades, including the mitogen-activated protein kinase pathway(s). It has also been suggested that 1,25(OH) 2 D 3 and its associated receptor have genomic targets, resulting in regulation of gene expression, as well as non-genomic functions that can alter cellular behaviour through binding and modification of targets not directly associated with transcriptional regulation. The molecular mechanisms of vitamin D signalling, however, have not been fully clarified. Vitamin D inadequacy or deficiency is associated with muscle fibre atrophy, increased risk of chronic musculoskeletal pain, sarcopenia and associated falls, and may also decrease RMR. The main purpose of the present review is to describe the molecular role of vitamin D in skeletal muscle tissue function and metabolism, specifically in relation to proliferation, differentiation and protein synthesis processes. In addition, the present review also includes discussion of possible genomic and non-genomic pathways of vitamin D action.
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ISSN:0954-4224
1475-2700
1475-2700
DOI:10.1017/S0954422419000064