Macrophage M1/M2 polarization

Macrophages can be affected by a variety of factors to change their phenotype and thus affect their function. Activated macrophages are usually divided into two categories, M1-like macrophages and M2-like macrophages. Both M1 macrophages and M2 macrophages are closely related to inflammatory respons...

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Bibliographic Details
Published in:European journal of pharmacology Vol. 877; p. 173090
Main Authors: Yunna, Chen, Mengru, Hu, Lei, Wang, Weidong, Chen
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 15.06.2020
Subjects:
Animals
Humans
Macrophage polarization
Macrophages - cytology
Nanocarriers
NF-κB
Nuclear receptor PPARγ
Signal Transduction
Tumor microenvironment
NF-κB
Nuclear receptor PPARγ
Macrophage polarization
Tumor microenvironment
Nanocarriers
ISSN:0014-2999, 1879-0712, 1879-0712
Online Access:Get full text
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Summary:Macrophages can be affected by a variety of factors to change their phenotype and thus affect their function. Activated macrophages are usually divided into two categories, M1-like macrophages and M2-like macrophages. Both M1 macrophages and M2 macrophages are closely related to inflammatory responses, among which M1 macrophages are mainly involved in pro-inflammatory responses and M2 macrophages are mainly involved in anti-inflammatory responses. Improving the inflammatory environment by modulating the activation state of macrophages is an effective method for the treatment of diseases. In this review, we analyzed the mechanism of macrophage polarization from the tumor microenvironment, nanocarriers, nuclear receptor PPARγ, phagocytosis, NF-κB signaling pathways, and other pathways.
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ISSN:0014-2999
1879-0712
1879-0712
DOI:10.1016/j.ejphar.2020.173090