Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices – A mini review

The metal/metal alloy-based implants and prostheses are in use for over a century, and the rejections, revisions, and metal particle-based toxicities were reported concurrently. Complications developed due to metal ions, metal debris, and organo-metallic particles in orthopedic patients have been a...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology letters Vol. 350; pp. 213 - 224
Main Authors: Badhe, Ravindra V., Akinfosile, Obakanyin, Bijukumar, Divya, Barba, Mark, Mathew, Mathew T.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 10.10.2021
Subjects:
Adult
Aged
Aged, 80 and over
Cardiotoxicity - etiology
Female
Heavy Metal Poisoning - blood
Heavy Metal Poisoning - etiology
Humans
Implants
Ions - blood
Ions - toxicity
Male
Metal ion concentration ranges
Metal toxicity
Metals - blood
Metals - toxicity
Middle Aged
Prostheses and Implants - adverse effects
Systemic effects of metal ions
Systemic effects of metal ions
Metal ion concentration ranges
Implants
Metal toxicity
ISSN:0378-4274, 1879-3169, 1879-3169
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The metal/metal alloy-based implants and prostheses are in use for over a century, and the rejections, revisions, and metal particle-based toxicities were reported concurrently. Complications developed due to metal ions, metal debris, and organo-metallic particles in orthopedic patients have been a growing concern in recent years. It was reported that local and systemic toxicity caused by such released products from the implants is one of the major reasons for implant rejection and revision. Even though the description of environmental metal toxicants and safety limits for their exposure to humans were well established in the literature, an effort was not adequately performed in the case of implant-based metal toxicology. Since the metal ion concentration in serum acts as a possible indicator of the systemic toxicity, this review summarizes the reported human serum safe limits, toxic limits, and concentration range (μg/L, ppb, etc.) for mild to severe symptoms of six (cardiac, hepatic, neuro, nephron, dermal and endocrine) systemic toxicities for twelve most commonly used metallic implants. It also covers the widely used metal ion quantification techniques and systemic toxicity treatments reported.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0378-4274
1879-3169
1879-3169
DOI:10.1016/j.toxlet.2021.07.004