Melatonin: A review of its potential functions and effects on neurological diseases

The aging process is not univocal, both body and brain age. Neurological disorders are a major cause of disability and death worldwide. According to the Global Burden of Disease Study 2015, neurological diseases are the second most common cause of death and 16.8% of total deaths are caused by neurol...

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Vydané v:Revue neurologique Ročník 176; číslo 3; s. 148 - 165
Hlavní autori: Gunata, M., Parlakpinar, H., Acet, H.A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: France Elsevier Masson SAS 01.03.2020
Predmet:
Aging - physiology
Alzheimer's disease
Animals
Epilepsy
History, 20th Century
History, 21st Century
Humans
Melatonin
Melatonin - pharmacology
Melatonin - physiology
Melatonin - therapeutic use
Multiple sclerosis
Nervous System Diseases - drug therapy
Nervous System Diseases - epidemiology
Nervous System Diseases - etiology
Neurology - history
Neurology - trends
Parkinson's disease
Melatonin
Multiple sclerosis
Parkinson's disease
Alzheimer's disease
Epilepsy
ISSN:0035-3787
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Abstract The aging process is not univocal, both body and brain age. Neurological disorders are a major cause of disability and death worldwide. According to the Global Burden of Disease Study 2015, neurological diseases are the second most common cause of death and 16.8% of total deaths are caused by neurological diseases worldwide. Neurological disease deaths have risen 36% worldwide in 25 years. Melatonin is a neuroregulator hormone that has free radical scavenger, strong antioxidant, anti-inflammatory, and immunosuppressive actions. These major properties of melatonin can play an important role in the pathophysiological mechanisms of neurological diseases. In addition, melatonin is necessary for circadian rhythm. Studies have shown that melatonin levels are low in people with neurological diseases. Both preventive and therapeutic effects of melatonin are known for many diseases, including neurological diseases (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, epilepsy, headache, etc.). Based on all these reasons, clinical trials of melatonin were performed and successful results were declared. In this review, biological and chemical knowledge of melatonin, its experimental effects, and the clinical impact on patients with neurological disorders were described. According to all of the beneficial results obtained from experimental and clinical trials, melatonin may have a prophylactic and therapeutic effect on neurological diseases. Strong collaboration between neurologists and health service policy makers is needed to encourage use of melatonin in the patients suffering from neurological diseases. Melatonin may be the solution we have been looking for.
AbstractList The aging process is not univocal, both body and brain age. Neurological disorders are a major cause of disability and death worldwide. According to the Global Burden of Disease Study 2015, neurological diseases are the second most common cause of death and 16.8% of total deaths are caused by neurological diseases worldwide. Neurological disease deaths have risen 36% worldwide in 25 years. Melatonin is a neuroregulator hormone that has free radical scavenger, strong antioxidant, anti-inflammatory, and immunosuppressive actions. These major properties of melatonin can play an important role in the pathophysiological mechanisms of neurological diseases. In addition, melatonin is necessary for circadian rhythm. Studies have shown that melatonin levels are low in people with neurological diseases. Both preventive and therapeutic effects of melatonin are known for many diseases, including neurological diseases (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, epilepsy, headache, etc.). Based on all these reasons, clinical trials of melatonin were performed and successful results were declared. In this review, biological and chemical knowledge of melatonin, its experimental effects, and the clinical impact on patients with neurological disorders were described. According to all of the beneficial results obtained from experimental and clinical trials, melatonin may have a prophylactic and therapeutic effect on neurological diseases. Strong collaboration between neurologists and health service policy makers is needed to encourage use of melatonin in the patients suffering from neurological diseases. Melatonin may be the solution we have been looking for.
The aging process is not univocal, both body and brain age. Neurological disorders are a major cause of disability and death worldwide. According to the Global Burden of Disease Study 2015, neurological diseases are the second most common cause of death and 16.8% of total deaths are caused by neurological diseases worldwide. Neurological disease deaths have risen 36% worldwide in 25 years. Melatonin is a neuroregulator hormone that has free radical scavenger, strong antioxidant, anti-inflammatory, and immunosuppressive actions. These major properties of melatonin can play an important role in the pathophysiological mechanisms of neurological diseases. In addition, melatonin is necessary for circadian rhythm. Studies have shown that melatonin levels are low in people with neurological diseases. Both preventive and therapeutic effects of melatonin are known for many diseases, including neurological diseases (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, epilepsy, headache, etc.). Based on all these reasons, clinical trials of melatonin were performed and successful results were declared.BACKGROUNDThe aging process is not univocal, both body and brain age. Neurological disorders are a major cause of disability and death worldwide. According to the Global Burden of Disease Study 2015, neurological diseases are the second most common cause of death and 16.8% of total deaths are caused by neurological diseases worldwide. Neurological disease deaths have risen 36% worldwide in 25 years. Melatonin is a neuroregulator hormone that has free radical scavenger, strong antioxidant, anti-inflammatory, and immunosuppressive actions. These major properties of melatonin can play an important role in the pathophysiological mechanisms of neurological diseases. In addition, melatonin is necessary for circadian rhythm. Studies have shown that melatonin levels are low in people with neurological diseases. Both preventive and therapeutic effects of melatonin are known for many diseases, including neurological diseases (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, epilepsy, headache, etc.). Based on all these reasons, clinical trials of melatonin were performed and successful results were declared.In this review, biological and chemical knowledge of melatonin, its experimental effects, and the clinical impact on patients with neurological disorders were described. According to all of the beneficial results obtained from experimental and clinical trials, melatonin may have a prophylactic and therapeutic effect on neurological diseases. Strong collaboration between neurologists and health service policy makers is needed to encourage use of melatonin in the patients suffering from neurological diseases. Melatonin may be the solution we have been looking for.CONCLUSIONSIn this review, biological and chemical knowledge of melatonin, its experimental effects, and the clinical impact on patients with neurological disorders were described. According to all of the beneficial results obtained from experimental and clinical trials, melatonin may have a prophylactic and therapeutic effect on neurological diseases. Strong collaboration between neurologists and health service policy makers is needed to encourage use of melatonin in the patients suffering from neurological diseases. Melatonin may be the solution we have been looking for.
Author Parlakpinar, H.
Gunata, M.
Acet, H.A.
Author_xml – sequence: 1
  givenname: M.
  surname: Gunata
  fullname: Gunata, M.
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  surname: Parlakpinar
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  givenname: H.A.
  surname: Acet
  fullname: Acet, H.A.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31718830$$D View this record in MEDLINE/PubMed
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ISSN 0035-3787
IngestDate Sun Sep 28 04:49:38 EDT 2025
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IsPeerReviewed true
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Issue 3
Keywords Melatonin
Multiple sclerosis
Parkinson's disease
Alzheimer's disease
Epilepsy
Language English
License Copyright © 2019 Elsevier Masson SAS. All rights reserved.
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PublicationTitle Revue neurologique
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PublicationYear 2020
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Snippet The aging process is not univocal, both body and brain age. Neurological disorders are a major cause of disability and death worldwide. According to the Global...
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SubjectTerms Aging - physiology
Alzheimer's disease
Animals
Epilepsy
History, 20th Century
History, 21st Century
Humans
Melatonin
Melatonin - pharmacology
Melatonin - physiology
Melatonin - therapeutic use
Multiple sclerosis
Nervous System Diseases - drug therapy
Nervous System Diseases - epidemiology
Nervous System Diseases - etiology
Neurology - history
Neurology - trends
Parkinson's disease
Title Melatonin: A review of its potential functions and effects on neurological diseases
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https://www.ncbi.nlm.nih.gov/pubmed/31718830
https://www.proquest.com/docview/2314251927
Volume 176
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