Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs

•Oxidative stress and inflammatory response induced by acrylamide in PC12 cells were revealed.•A crosstalk between Nrf2 and NF-κB signaling pathways regulated by MAPKs existed in ACR-induced cell damage.•NAC could protect against oxidative damage and inflammatory response induced by ACR via regulati...

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Bibliographic Details
Published in:	Toxicology letters Vol. 288; pp. 55 - 64
Main Authors:	Pan, Xiaoqi, Wu, Xu, Yan, Dandan, Peng, Cheng, Rao, Chaolong, Yan, Hong
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15.05.2018
Subjects:	Acrylamide MAPKs N-acetylcysteine Neurotoxicity NF-κB Nrf2 NF-κ COX-2 DMSO JNK HO-1 MDA MTT N-acetylcysteine BSA Acrylamide NF-κB FITC TBA Neurotoxicity Nrf2 FBS GSH MAPKs NQO-1 DAPI NGF IL-6 ACR NAC DCFH-DA TNF-α ROS Keap1 ERK ELISA B NF-&kappa
ISSN:	0378-4274, 1879-3169, 1879-3169
Online Access:	Get full text
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