Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome

•200 mg/kg propofol treatment (intraperitoneal injection, i.p.) every 9 days, with a total of 6 times did not affect the cognition of the aged rats.•200 mg/kg propofol treatment i.p.) every day, with a total of 6 times impaired the cognition of the aged rats.•Propofol induced cognitive dysfunction p...

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Bibliographic Details
Published in:	Neuroscience letters Vol. 740; p. 135461
Main Authors:	Liu, Peng-fei, Gao, Teng, Li, Tian-zuo, Yang, Yi-tian, Xu, Yong-xing, Xu, Zhi-peng, Mi, Wei-dong
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01.01.2021
Subjects:	Aging Aging - psychology Anesthetics, Intravenous - toxicity Animals Apoptosis Cognition - drug effects Cognition Disorders - chemically induced Cognition Disorders - psychology Conditioning, Operant - drug effects Hippocampus - metabolism Inflammasomes - drug effects Male Maze Learning - drug effects Memory - drug effects Neuroinflammation Neurons - pathology NF-kappa B - antagonists & inhibitors NF-kappa B - drug effects NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors NLR Family, Pyrin Domain-Containing 3 Protein - drug effects NOD-like receptor protein 3 inflammasome Postoperative cognitive dysfunction Propofol Propofol - toxicity Rats Rats, Sprague-Dawley PaCO2 dUTP POCD DMSO WB Pro Postoperative cognitive dysfunction p-NF-κB NF-κB Aβ SE CA1 TUNEL CA3 ANOVA Pro+Bay pH Aging NLRP3 Propofol IκBa Con+Bay PBS MWM Con IKK-β Neuroinflammation i.p IL-1β IL-6 Bay 11-7082 PaO2 TNF-α FCT NOD-like receptor protein 3 inflammasome GAPDH ELISA Apoptosis
ISSN:	0304-3940, 1872-7972, 1872-7972
Online Access:	Get full text
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