Radical scavenging effect of skin delivery systems using Korean red ginseng extract and assessment of their biocompatibility with human primary dermal fibroblasts and HaCaT keratinocytes

[Display omitted] Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study aimed to optimize new multi- and monophase vehicles for KRG extract delivery, assess their biocompatibility and evaluate their radical scavenging...

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Veröffentlicht in:International journal of pharmaceutics Jg. 674; S. 125477
Hauptverfasser: Pfleger, Tanja, Ortmayr, Karin, Steiner, Katja, Zaher, Rawan, Seiser, Saskia, Elbe-Bürger, Adelheid, Heiss, Elke, Klang, Victoria
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 15.04.2025
Schlagworte:
Administration, Cutaneous
Antioxidants - chemistry
Biphenyl Compounds - chemistry
Cell Survival - drug effects
DPPH
Drug Delivery Systems
Drug Liberation
Emulsions
Fibroblasts - drug effects
Free Radical Scavengers - administration & dosage
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
Ginsenosides - administration & dosage
Ginsenosides - chemistry
Ginsenosides - pharmacology
HaCaT Cells
HaCaT keratinocytes
Humans
Hydrogel
Keratinocytes - drug effects
Korean red ginseng extract
Nanoemulsion
Panax - chemistry
Picrates
Plant Extracts - administration & dosage
Plant Extracts - chemistry
Plant Extracts - pharmacology
Primary human dermal fibroblasts
Release studies
Skin - cytology
Skin - drug effects
Skin - metabolism
HaCaT keratinocytes
Release studies
KRG
PPD
LVR
DLS
MTT
DMEM
PTT
PDI
FBS
UHPLC/MS
HYP
PBS
UV
DPPH
Nanoemulsion
Korean red ginseng extract
MMP
ZP
Primary human dermal fibroblasts
NE
ROS
Hydrogel
HaCaT
HLB
MCT
ISSN:0378-5173, 1873-3476, 1873-3476
Online-Zugang:Volltext
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Zusammenfassung:[Display omitted] Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study aimed to optimize new multi- and monophase vehicles for KRG extract delivery, assess their biocompatibility and evaluate their radical scavenging effect in vitro. Storage stability of oil-in-water nanoemulsions (NEs) and hydroalcoholic gels (2 % w/w KRG) was assessed over twelve weeks using dynamic light scattering, rheology and pH measurements. Release profiles of ginsenosides Rb1 (more hydrophilic) and Rg1 (moderately lipophilic) through a cellulose membrane were also investigated employing Franz diffusion cells. Antioxidant potential and biocompatibility were assessed via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cell viability assays. Vehicles remained stable over twelve weeks at 8 °C (NEs Dh stable, gel viscosity + 3.5 %). Diffusion studies showed higher release of Rg1 vs. Rb1 (7.10 vs. 1.39 µg/cm−2 after 28 h). KRG-formulations demonstrated good biocompatibility with primary human dermal fibroblasts and HaCaT keratinocytes (72–94 % viability). Radical scavenging capacity of KRG extract did not differ between pure and incorporated form and was lower than that of a Hypericum extract or ascorbic acid. Results render KRG-formulations a potentially promising alternative to conventional antioxidants used in daily products.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-5173
1873-3476
1873-3476
DOI:10.1016/j.ijpharm.2025.125477