Radical scavenging effect of skin delivery systems using Korean red ginseng extract and assessment of their biocompatibility with human primary dermal fibroblasts and HaCaT keratinocytes

[Display omitted] Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study aimed to optimize new multi- and monophase vehicles for KRG extract delivery, assess their biocompatibility and evaluate their radical scavenging...

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Veröffentlicht in:	International journal of pharmaceutics Jg. 674; S. 125477
Hauptverfasser:	Pfleger, Tanja, Ortmayr, Karin, Steiner, Katja, Zaher, Rawan, Seiser, Saskia, Elbe-Bürger, Adelheid, Heiss, Elke, Klang, Victoria
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 15.04.2025
Schlagworte:	Administration, Cutaneous Antioxidants - chemistry Biphenyl Compounds - chemistry Cell Survival - drug effects DPPH Drug Delivery Systems Drug Liberation Emulsions Fibroblasts - drug effects Free Radical Scavengers - administration & dosage Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Ginsenosides - administration & dosage Ginsenosides - chemistry Ginsenosides - pharmacology HaCaT Cells HaCaT keratinocytes Humans Hydrogel Keratinocytes - drug effects Korean red ginseng extract Nanoemulsion Panax - chemistry Picrates Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Primary human dermal fibroblasts Release studies Skin - cytology Skin - drug effects Skin - metabolism HaCaT keratinocytes Release studies KRG PPD LVR DLS MTT DMEM PTT PDI FBS UHPLC/MS HYP PBS UV DPPH Nanoemulsion Korean red ginseng extract MMP ZP Primary human dermal fibroblasts NE ROS Hydrogel HaCaT HLB MCT
ISSN:	0378-5173, 1873-3476, 1873-3476
Online-Zugang:	Volltext
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