Radical scavenging effect of skin delivery systems using Korean red ginseng extract and assessment of their biocompatibility with human primary dermal fibroblasts and HaCaT keratinocytes

[Display omitted] Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study aimed to optimize new multi- and monophase vehicles for KRG extract delivery, assess their biocompatibility and evaluate their radical scavenging...

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Published in:	International journal of pharmaceutics Vol. 674; p. 125477
Main Authors:	Pfleger, Tanja, Ortmayr, Karin, Steiner, Katja, Zaher, Rawan, Seiser, Saskia, Elbe-Bürger, Adelheid, Heiss, Elke, Klang, Victoria
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15.04.2025
Subjects:	Administration, Cutaneous Antioxidants - chemistry Biphenyl Compounds - chemistry Cell Survival - drug effects DPPH Drug Delivery Systems Drug Liberation Emulsions Fibroblasts - drug effects Free Radical Scavengers - administration & dosage Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Ginsenosides - administration & dosage Ginsenosides - chemistry Ginsenosides - pharmacology HaCaT Cells HaCaT keratinocytes Humans Hydrogel Keratinocytes - drug effects Korean red ginseng extract Nanoemulsion Panax - chemistry Picrates Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Primary human dermal fibroblasts Release studies Skin - cytology Skin - drug effects Skin - metabolism HaCaT keratinocytes Release studies KRG PPD LVR DLS MTT DMEM PTT PDI FBS UHPLC/MS HYP PBS UV DPPH Nanoemulsion Korean red ginseng extract MMP ZP Primary human dermal fibroblasts NE ROS Hydrogel HaCaT HLB MCT
ISSN:	0378-5173, 1873-3476, 1873-3476
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Abstract	[Display omitted] Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study aimed to optimize new multi- and monophase vehicles for KRG extract delivery, assess their biocompatibility and evaluate their radical scavenging effect in vitro. Storage stability of oil-in-water nanoemulsions (NEs) and hydroalcoholic gels (2 % w/w KRG) was assessed over twelve weeks using dynamic light scattering, rheology and pH measurements. Release profiles of ginsenosides Rb1 (more hydrophilic) and Rg1 (moderately lipophilic) through a cellulose membrane were also investigated employing Franz diffusion cells. Antioxidant potential and biocompatibility were assessed via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cell viability assays. Vehicles remained stable over twelve weeks at 8 °C (NEs Dh stable, gel viscosity + 3.5 %). Diffusion studies showed higher release of Rg1 vs. Rb1 (7.10 vs. 1.39 µg/cm−2 after 28 h). KRG-formulations demonstrated good biocompatibility with primary human dermal fibroblasts and HaCaT keratinocytes (72–94 % viability). Radical scavenging capacity of KRG extract did not differ between pure and incorporated form and was lower than that of a Hypericum extract or ascorbic acid. Results render KRG-formulations a potentially promising alternative to conventional antioxidants used in daily products.
AbstractList	Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study aimed to optimize new multi- and monophase vehicles for KRG extract delivery, assess their biocompatibility and evaluate their radical scavenging effect in vitro. Storage stability of oil-in-water nanoemulsions (NEs) and hydroalcoholic gels (2 % w/w KRG) was assessed over twelve weeks using dynamic light scattering, rheology and pH measurements. Release profiles of ginsenosides Rb1 (more hydrophilic) and Rg1 (moderately lipophilic) through a cellulose membrane were also investigated employing Franz diffusion cells. Antioxidant potential and biocompatibility were assessed via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cell viability assays. Vehicles remained stable over twelve weeks at 8 °C (NEs Dh stable, gel viscosity + 3.5 %). Diffusion studies showed higher release of Rg1 vs. Rb1 (7.10 vs. 1.39 µg/cm-2 after 28 h). KRG-formulations demonstrated good biocompatibility with primary human dermal fibroblasts and HaCaT keratinocytes (72-94 % viability). Radical scavenging capacity of KRG extract did not differ between pure and incorporated form and was lower than that of a Hypericum extract or ascorbic acid. Results render KRG-formulations a potentially promising alternative to conventional antioxidants used in daily products.Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study aimed to optimize new multi- and monophase vehicles for KRG extract delivery, assess their biocompatibility and evaluate their radical scavenging effect in vitro. Storage stability of oil-in-water nanoemulsions (NEs) and hydroalcoholic gels (2 % w/w KRG) was assessed over twelve weeks using dynamic light scattering, rheology and pH measurements. Release profiles of ginsenosides Rb1 (more hydrophilic) and Rg1 (moderately lipophilic) through a cellulose membrane were also investigated employing Franz diffusion cells. Antioxidant potential and biocompatibility were assessed via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cell viability assays. Vehicles remained stable over twelve weeks at 8 °C (NEs Dh stable, gel viscosity + 3.5 %). Diffusion studies showed higher release of Rg1 vs. Rb1 (7.10 vs. 1.39 µg/cm-2 after 28 h). KRG-formulations demonstrated good biocompatibility with primary human dermal fibroblasts and HaCaT keratinocytes (72-94 % viability). Radical scavenging capacity of KRG extract did not differ between pure and incorporated form and was lower than that of a Hypericum extract or ascorbic acid. Results render KRG-formulations a potentially promising alternative to conventional antioxidants used in daily products. [Display omitted] Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study aimed to optimize new multi- and monophase vehicles for KRG extract delivery, assess their biocompatibility and evaluate their radical scavenging effect in vitro. Storage stability of oil-in-water nanoemulsions (NEs) and hydroalcoholic gels (2 % w/w KRG) was assessed over twelve weeks using dynamic light scattering, rheology and pH measurements. Release profiles of ginsenosides Rb1 (more hydrophilic) and Rg1 (moderately lipophilic) through a cellulose membrane were also investigated employing Franz diffusion cells. Antioxidant potential and biocompatibility were assessed via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cell viability assays. Vehicles remained stable over twelve weeks at 8 °C (NEs Dh stable, gel viscosity + 3.5 %). Diffusion studies showed higher release of Rg1 vs. Rb1 (7.10 vs. 1.39 µg/cm−2 after 28 h). KRG-formulations demonstrated good biocompatibility with primary human dermal fibroblasts and HaCaT keratinocytes (72–94 % viability). Radical scavenging capacity of KRG extract did not differ between pure and incorporated form and was lower than that of a Hypericum extract or ascorbic acid. Results render KRG-formulations a potentially promising alternative to conventional antioxidants used in daily products. Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study aimed to optimize new multi- and monophase vehicles for KRG extract delivery, assess their biocompatibility and evaluate their radical scavenging effect in vitro. Storage stability of oil-in-water nanoemulsions (NEs) and hydroalcoholic gels (2 % w/w KRG) was assessed over twelve weeks using dynamic light scattering, rheology and pH measurements. Release profiles of ginsenosides Rb1 (more hydrophilic) and Rg1 (moderately lipophilic) through a cellulose membrane were also investigated employing Franz diffusion cells. Antioxidant potential and biocompatibility were assessed via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cell viability assays. Vehicles remained stable over twelve weeks at 8 °C (NEs D stable, gel viscosity + 3.5 %). Diffusion studies showed higher release of Rg1 vs. Rb1 (7.10 vs. 1.39 µg/cm after 28 h). KRG-formulations demonstrated good biocompatibility with primary human dermal fibroblasts and HaCaT keratinocytes (72-94 % viability). Radical scavenging capacity of KRG extract did not differ between pure and incorporated form and was lower than that of a Hypericum extract or ascorbic acid. Results render KRG-formulations a potentially promising alternative to conventional antioxidants used in daily products.
ArticleNumber	125477
Author	Steiner, Katja Klang, Victoria Pfleger, Tanja Zaher, Rawan Ortmayr, Karin Seiser, Saskia Heiss, Elke Elbe-Bürger, Adelheid
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Keywords	HaCaT keratinocytes Release studies KRG PPD LVR DLS MTT DMEM PTT PDI FBS UHPLC/MS HYP PBS UV DPPH Nanoemulsion Korean red ginseng extract MMP ZP Primary human dermal fibroblasts NE ROS Hydrogel HaCaT HLB MCT
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Snippet	[Display omitted] Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study... Korean red ginseng (KRG) extract is proposed for cosmetic use, but no data on biological effects of KRG-loaded vehicles exist. The study aimed to optimize new...
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SubjectTerms	Administration, Cutaneous Antioxidants - chemistry Biphenyl Compounds - chemistry Cell Survival - drug effects DPPH Drug Delivery Systems Drug Liberation Emulsions Fibroblasts - drug effects Free Radical Scavengers - administration & dosage Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Ginsenosides - administration & dosage Ginsenosides - chemistry Ginsenosides - pharmacology HaCaT Cells HaCaT keratinocytes Humans Hydrogel Keratinocytes - drug effects Korean red ginseng extract Nanoemulsion Panax - chemistry Picrates Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Primary human dermal fibroblasts Release studies Skin - cytology Skin - drug effects Skin - metabolism
Title	Radical scavenging effect of skin delivery systems using Korean red ginseng extract and assessment of their biocompatibility with human primary dermal fibroblasts and HaCaT keratinocytes
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