Polyphyllin VII ameliorates neuroinflammation and brain injury via modulating Treg/Th17 balance in a mouse model of cerebral ischemia-reperfusion injury

•Polyphyllin VII reduced infarct volume, ameliorated brain injury and neuroinflammation, and improved long-term functional recovery of MCAO mice.•Polyphyllin VII increased infiltration of Treg cells and suppressed infiltration of Th1/Th17 cells in ischemic brain.•Polyphyllin VII suppressed mTORC1 ac...

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Veröffentlicht in:	International immunopharmacology Jg. 143; H. Pt 2; S. 113423
Hauptverfasser:	Sang, Qiuling, Kang, Chunyang, Liu, Dingxi, Wang, Libo, Liu, Xiaoyang, Li, Jia
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 25.12.2024
Schlagworte:	Animals Brain - drug effects Brain - metabolism Brain - pathology Brain Injuries - drug therapy Brain Ischemia - drug therapy Brain Ischemia - immunology Cerebral ischemia–reperfusion injury Disease Models, Animal Glycolytic metabolism Humans Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - immunology Male Mice Mice, Inbred C57BL mTORC1 Neuroinflammatory Diseases - drug therapy Neuroinflammatory Diseases - immunology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Polyphyllin VII Reperfusion Injury - drug therapy Reperfusion Injury - immunology Saponins - pharmacology Saponins - therapeutic use T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th17 Cells - drug effects Th17 Cells - immunology Treg/Th17 polarization Polyphyllin VII Treg/Th17 polarization Cerebral ischemia–reperfusion injury mTORC1 Glycolytic metabolism
ISSN:	1567-5769, 1878-1705, 1878-1705
Online-Zugang:	Volltext
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