Simultaneous detection of glucose, uric acid and cholesterol using flexible microneedle electrode array-based biosensor and multi-channel portable electrochemical analyzer

[Display omitted] •A flexible microneedle electrode array-based biosensor (MEAB) was fabricated.•A homemade multi-channel portable electrochemical analyzer (MPEA) was developed.•Simultaneous detection of glucose, uric acid and cholesterol was achieved by using MPEA and MEAB. The development of versa...

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Published in:	Sensors and actuators. B, Chemical Vol. 287; pp. 102 - 110
Main Authors:	Gao, Jie, Huang, Wenzheng, Chen, Zhipeng, Yi, Changqing, Jiang, Lelun
Format:	Journal Article
Language:	English
Published:	Lausanne Elsevier B.V 15.05.2019 Elsevier Science Ltd
Subjects:	Arrays Biosensors Blood Cholesterol Cholesterol oxidase Conditioning Cost analysis Electrodes Glucose Glucose oxidase Gold Metabolites Microcontrollers Microneedle electrode array Multi-channel portable electrochemical analyzer Multiplexed detection Portable equipment Response time Substrates Uric acid Workstations Microneedle electrode array Glucose Uric acid Multiplexed detection Multi-channel portable electrochemical analyzer Cholesterol
ISSN:	0925-4005, 1873-3077
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Abstract	[Display omitted] •A flexible microneedle electrode array-based biosensor (MEAB) was fabricated.•A homemade multi-channel portable electrochemical analyzer (MPEA) was developed.•Simultaneous detection of glucose, uric acid and cholesterol was achieved by using MPEA and MEAB. The development of versatile and low-cost biosensor system for rapid and simultaneous detection of multiple blood metabolites is highly demanded for home healthcare. We developed a flexible microneedle electrode array-based biosensor (MEAB) and a multi-channel portable electrochemical analyzer (MPEA) for the simultaneous detection of glucose, uric acid, and cholesterol. Microneedle electrode array (MEA) was fabricated on the flexible substrate using magnetorheological drawing lithography, followed by sputter coated with Au/Ti film. Then, through biofunctionalized with glucose oxidase, uricase and cholesterol oxidase, MEA was conditioned as a biosensor for simultaneous detection of glucose, uric acid and cholesterol. MEAB demonstrated excellent sensing performance with a wide linear range (glucose, 2–12 mM; uric acid, 0.1–1.2 mM; cholesterol, 1–12 mM), low detection limit (glucose, 260 μM; uric acid, 4 μM; cholesterol, 440 μM), and rapid response time (∼4 s). MPEA, a homemade ARM STM32 microcontroller-based electrochemical analyzer, was validated to be comparable to that of the commercial electrochemical workstation. MPEA integrated with flexible MEAB could accurately and simultaneously detect glucose, uric acid, and cholesterol levels in serum, and the results were consistent with the portable electrochemical device. The ease-of-use of the reported biosensor system will facilitate effective monitoring of blood metabolites at home.
AbstractList	The development of versatile and low-cost biosensor system for rapid and simultaneous detection of multiple blood metabolites is highly demanded for home healthcare. We developed a flexible microneedle electrode array-based biosensor (MEAB) and a multi-channel portable electrochemical analyzer (MPEA) for the simultaneous detection of glucose, uric acid, and cholesterol. Microneedle electrode array (MEA) was fabricated on the flexible substrate using magnetorheological drawing lithography, followed by sputter coated with Au/Ti film. Then, through biofunctionalized with glucose oxidase, uricase and cholesterol oxidase, MEA was conditioned as a biosensor for simultaneous detection of glucose, uric acid and cholesterol. MEAB demonstrated excellent sensing performance with a wide linear range (glucose, 2–12 mM; uric acid, 0.1–1.2 mM; cholesterol, 1–12 mM), low detection limit (glucose, 260 μM; uric acid, 4 μM; cholesterol, 440 μM), and rapid response time (∼4 s). MPEA, a homemade ARM STM32 microcontroller-based electrochemical analyzer, was validated to be comparable to that of the commercial electrochemical workstation. MPEA integrated with flexible MEAB could accurately and simultaneously detect glucose, uric acid, and cholesterol levels in serum, and the results were consistent with the portable electrochemical device. The ease-of-use of the reported biosensor system will facilitate effective monitoring of blood metabolites at home. [Display omitted] •A flexible microneedle electrode array-based biosensor (MEAB) was fabricated.•A homemade multi-channel portable electrochemical analyzer (MPEA) was developed.•Simultaneous detection of glucose, uric acid and cholesterol was achieved by using MPEA and MEAB. The development of versatile and low-cost biosensor system for rapid and simultaneous detection of multiple blood metabolites is highly demanded for home healthcare. We developed a flexible microneedle electrode array-based biosensor (MEAB) and a multi-channel portable electrochemical analyzer (MPEA) for the simultaneous detection of glucose, uric acid, and cholesterol. Microneedle electrode array (MEA) was fabricated on the flexible substrate using magnetorheological drawing lithography, followed by sputter coated with Au/Ti film. Then, through biofunctionalized with glucose oxidase, uricase and cholesterol oxidase, MEA was conditioned as a biosensor for simultaneous detection of glucose, uric acid and cholesterol. MEAB demonstrated excellent sensing performance with a wide linear range (glucose, 2–12 mM; uric acid, 0.1–1.2 mM; cholesterol, 1–12 mM), low detection limit (glucose, 260 μM; uric acid, 4 μM; cholesterol, 440 μM), and rapid response time (∼4 s). MPEA, a homemade ARM STM32 microcontroller-based electrochemical analyzer, was validated to be comparable to that of the commercial electrochemical workstation. MPEA integrated with flexible MEAB could accurately and simultaneously detect glucose, uric acid, and cholesterol levels in serum, and the results were consistent with the portable electrochemical device. The ease-of-use of the reported biosensor system will facilitate effective monitoring of blood metabolites at home.
Author	Gao, Jie Jiang, Lelun Chen, Zhipeng Huang, Wenzheng Yi, Changqing
Author_xml	– sequence: 1 givenname: Jie surname: Gao fullname: Gao, Jie organization: Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, 510006, PR China – sequence: 2 givenname: Wenzheng surname: Huang fullname: Huang, Wenzheng organization: Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, 510006, PR China – sequence: 3 givenname: Zhipeng surname: Chen fullname: Chen, Zhipeng organization: Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, 510006, PR China – sequence: 4 givenname: Changqing surname: Yi fullname: Yi, Changqing email: yichq@mail.sysu.edu.cn organization: Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, 510006, PR China – sequence: 5 givenname: Lelun surname: Jiang fullname: Jiang, Lelun email: jianglel@mail.sysu.edu.cn organization: Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, 510006, PR China
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Snippet	[Display omitted] •A flexible microneedle electrode array-based biosensor (MEAB) was fabricated.•A homemade multi-channel portable electrochemical analyzer... The development of versatile and low-cost biosensor system for rapid and simultaneous detection of multiple blood metabolites is highly demanded for home...
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SubjectTerms	Arrays Biosensors Blood Cholesterol Cholesterol oxidase Conditioning Cost analysis Electrodes Glucose Glucose oxidase Gold Metabolites Microcontrollers Microneedle electrode array Multi-channel portable electrochemical analyzer Multiplexed detection Portable equipment Response time Substrates Uric acid Workstations
Title	Simultaneous detection of glucose, uric acid and cholesterol using flexible microneedle electrode array-based biosensor and multi-channel portable electrochemical analyzer
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