KLF5/MDM2 Axis Modulates Oxidative Stress and Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells: The Role in Diabetic Cataract

Diabetic cataract (DC) is a common cause of visual loss in older diabetic subjects. Krüppel-like factor 5 (KLF5) plays an essential role in migration and the epithelial-mesenchymal transition (EMT) in diverse cells and is involved in oxidative stress. However, the effects of KLF5 on DC remain unknow...

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Bibliographic Details
Published in:	Laboratory investigation Vol. 103; no. 11; p. 100226
Main Authors:	Li, Xiao, Chen, Doudou, Ouyang, Bowen, Wang, Shengnan, Li, Yawei, Li, Li, Zhu, Siquan, Zheng, Guangying
Format:	Journal Article
Language:	English
Published:	United States 01.11.2023
Subjects:	Aged Animals Cataract - metabolism Diabetes Mellitus - metabolism Epithelial Cells - metabolism Epithelial-Mesenchymal Transition Humans Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Mice Oxidative Stress Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Rats MDM2 epithelial-mesenchymal transition KLF5 diabetic cataract oxidative stress
ISSN:	1530-0307, 1530-0307
Online Access:	Get more information
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