Whole cigarette smoke condensates induce ferroptosis in human bronchial epithelial cells

Cigarette smoke is responsible for many fatal pulmonary diseases, however, the toxic mechanism is still unclear. In this study, we first confirmed that whole cigarette smoke condensates (WCSC) contain hydrophilic elements, lipophilic and gaseous components. Then, we treated BEAS-2B cells, a normal h...

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Bibliographic Details
Published in:	Toxicology letters Vol. 303; pp. 55 - 66
Main Authors:	Park, Eun-Jung, Park, Yoo-Jin, Lee, Sang Jin, Lee, Kyuhong, Yoon, Cheolho
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15.03.2019
Subjects:	Apoptosis - drug effects Apoptotic Protease-Activating Factor 1 - genetics Apoptotic Protease-Activating Factor 1 - metabolism Autophagosomes - drug effects bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Bronchi - cytology Bronchi - metabolism Caspase 3 - genetics Caspase 3 - metabolism Cell Line Cell Survival - drug effects Dose-Response Relationship, Drug Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - drug effects Epithelial Cells - drug effects Epithelial Cells - metabolism ER stress Feroptosis Humans Hypoxia Interleukin-6 - metabolism Interleukin-8 - metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Dynamics - drug effects Nicotiana - adverse effects Reactive Oxygen Species - metabolism Smoke - adverse effects Whole cigarette smoke condensate ER stress Hypoxia Mitochondria Feroptosis Whole cigarette smoke condensate
ISSN:	0378-4274, 1879-3169, 1879-3169
Online Access:	Get full text
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