Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2

•Concurrent MTEP and NS398 reduced mGluR7 in WT mice hippocampus.•Concomitant MTEP and NS398 impaired the memory in mGluR7 KO mouse.•Simultaneous MTEP and NS398 blocked the antidepressant-like effects of AMN082. Our earlier study demonstrated, that antidepressant-like and also cognitive action of MT...

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Bibliographic Details
Published in:Neuroscience letters Vol. 741; p. 135435
Main Authors: Stachowicz, Katarzyna, Sowa-Kućma, Magdalena, Pańczyszyn-Trzewik, Patrycja, Misztak, Paulina, Marciniak, Marcin, Bobula, Bartosz, Tokarski, Krzysztof
Format: Journal Article
Language:English
Published: Ireland Elsevier B.V 10.01.2021
Subjects:
Animals
Behavior, Animal - drug effects
COX-2
Cyclooxygenase 2 Inhibitors - administration & dosage
Hippocampus - drug effects
Hippocampus - metabolism
Hippocampus - physiology
mGluR7
Mice
Mice, Knockout
Modified Barnes maze
Nitrobenzenes - administration & dosage
Pyridines - administration & dosage
Receptor, Metabotropic Glutamate 5 - antagonists & inhibitors
Receptors, Metabotropic Glutamate - metabolism
Sulfonamides - administration & dosage
Thiazoles - administration & dosage
TST
mGluR7
Modified Barnes maze
TST
COX-2
ISSN:0304-3940, 1872-7972, 1872-7972
Online Access:Get full text
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Summary:•Concurrent MTEP and NS398 reduced mGluR7 in WT mice hippocampus.•Concomitant MTEP and NS398 impaired the memory in mGluR7 KO mouse.•Simultaneous MTEP and NS398 blocked the antidepressant-like effects of AMN082. Our earlier study demonstrated, that antidepressant-like and also cognitive action of MTEP, a metabotropic glutamate receptor subtype 5 (mGluR5) antagonist, was influenced by cyclooxygenase-2 (COX-2) inhibition in mice. We detected a decrease in the mGluR7 protein level in the hippocampus (HC) of mice co-treated chronically with MTEP and NS398 (a COX-2 inhibitor). We found both antidepressant-like effects and cognitive to be associated with mGlu7 receptor-mediated mechanisms.
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ISSN:0304-3940
1872-7972
1872-7972
DOI:10.1016/j.neulet.2020.135435