Mutational analysis of putative phosphate- and proton-binding sites in the Saccharomyces cerevisiae Pho84 phosphate:H(+) transceptor and its effect on signalling to the PKA and PHO pathways

In Saccharomyces cerevisiae, the Pho84 phosphate transporter acts as the main provider of phosphate to the cell using a proton symport mechanism, but also mediates rapid activation of the PKA (protein kinase A) pathway. These two features led to recognition of Pho84 as a transceptor. Although the ph...

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Bibliographic Details
Published in:	Biochemical journal Vol. 445; no. 3; p. 413
Main Authors:	Samyn, Dieter R, Ruiz-Pávon, Lorena, Andersson, Michael R, Popova, Yulia, Thevelein, Johan M, Persson, Bengt L
Format:	Journal Article
Language:	English
Published:	England 01.08.2012
Subjects:	Acid Phosphatase - genetics Acid Phosphatase - metabolism Amino Acid Sequence Amino Acid Substitution Base Sequence Binding Sites - genetics Cyclic AMP-Dependent Protein Kinases - metabolism DNA, Fungal - genetics Genes, Fungal Kinetics Models, Biological Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Phosphates - metabolism Proton-Phosphate Symporters - chemistry Proton-Phosphate Symporters - genetics Proton-Phosphate Symporters - metabolism Protons Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Homology, Amino Acid Signal Transduction
ISSN:	1470-8728, 1470-8728
Online Access:	Get more information
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