Classification of test agent-specific effects in the Syrian hamster embryo assay (pH 6.7) using infrared spectroscopy with computational analysis

The Syrian hamster embryo (SHE) cell transformation assay (pH 6.7) has utility in the assessment of potential chemical carcinogenicity (both genotoxic and non-genotoxic mechanisms of action). The assay uses morphological transformation as an end point and has a reported sensitivity of 87%, specifici...

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Bibliographic Details
Published in:	Mutagenesis Vol. 27; no. 3; p. 375
Main Authors:	Ahmadzai, Abdullah A, Trevisan, Júlio, Pang, Weiyi, Patel, Imran I, Fullwood, Nigel J, Bruce, Shannon W, Pant, Kamala, Carmichael, Paul L, Scott, Andrew D, Martin, Francis L
Format:	Journal Article
Language:	English
Published:	England 01.05.2012
Subjects:	Animals Biomarkers - metabolism Carcinogens - classification Carcinogens - toxicity Cell Transformation, Neoplastic Cells, Cultured Cricetinae Data Interpretation, Statistical Embryo, Mammalian - cytology Hydrogen-Ion Concentration Linear Models Mesocricetus Mutagenicity Tests - methods Mutagens - classification Mutagens - toxicity Spectroscopy, Fourier Transform Infrared
ISSN:	1464-3804, 1464-3804
Online Access:	Get more information
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