Does Leptin and Insulin Levels Influence Pain and Disability in Subjects With Frozen Shoulder? A Cross‐Sectional Study
ABSTRACT Objective To investigate the relationship between leptin levels, insulin resistance (measured by HOMA), and clinical outcomes related to pain, disability, and shoulder range of motion (ROM) in patients with frozen shoulder (FS). Methods This cross‐sectional study included 34 patients diagno...
Gespeichert in:
| Veröffentlicht in: | European journal of pain Jg. 29; H. 4; S. e70007 - n/a |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
England
01.04.2025
|
| Schlagworte: | |
| ISSN: | 1090-3801, 1532-2149, 1532-2149 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | ABSTRACT
Objective
To investigate the relationship between leptin levels, insulin resistance (measured by HOMA), and clinical outcomes related to pain, disability, and shoulder range of motion (ROM) in patients with frozen shoulder (FS).
Methods
This cross‐sectional study included 34 patients diagnosed with FS. Leptin and HOMA levels were measured and analysed in relation to pain and disability scores, as assessed by the Shoulder Pain and Disability Index (SPADI), along with shoulder ROM (flexion, extension, abduction, adduction, and internal/external rotation). Linear regression models were used to evaluate associations between leptin, HOMA, and clinical outcomes, adjusting for potential confounders such as age and sex.
Results
Higher leptin levels were significantly associated with increased SPADI pain (R2 = 0.114, β = 0.397, p = 0.005) and disability scores (R2 = 0.110, β = 0.425, p = 0.006), as well as an inverse association with shoulder flexion (R2 = 0.074, β = −1.088, p = 0.025), indicating reduced ROM with higher leptin levels. Similarly, higher HOMA levels were associated with increased SPADI pain (R2 = 0.096, β = 1.078, p = 0.010) and disability scores (R2 = 0.081, β = 1.517, p = 0.017), as well as combined SPADI scores (R2 = 0.089, β = 2.595, p = 0.014). HOMA also showed a significant inverse relationship with shoulder flexion (R2 = 0.061, β = −2.097, p = 0.028), suggesting that insulin resistance may contribute to ROM limitations.
Conclusion
Elevated leptin and insulin resistance levels were linked to greater pain, disability, and decreased ROM in patients with FS. These findings underscore the potential role of metabolic and inflammatory pathways in FS pathogenesis and highlight the importance of considering lifestyle interventions targeting leptin and insulin regulation as adjuncts to traditional management strategies for this condition.
Significance Statement
Elevated levels of leptin and HOMA (insulin resistance) are significantly associated with increased pain and disability in patients with frozen shoulder, as measured by SPADI scores. Higher leptin and HOMA levels are also associated with reduced range of motion, particularly in shoulder flexion. Targeting metabolic and inflammatory markers such as leptin and insulin resistance could inform new therapeutic approaches for managing frozen shoulder, with potential implications for treatment strategies in other inflammatory musculoskeletal conditions. |
|---|---|
| AbstractList | To investigate the relationship between leptin levels, insulin resistance (measured by HOMA), and clinical outcomes related to pain, disability, and shoulder range of motion (ROM) in patients with frozen shoulder (FS).OBJECTIVETo investigate the relationship between leptin levels, insulin resistance (measured by HOMA), and clinical outcomes related to pain, disability, and shoulder range of motion (ROM) in patients with frozen shoulder (FS).This cross-sectional study included 34 patients diagnosed with FS. Leptin and HOMA levels were measured and analysed in relation to pain and disability scores, as assessed by the Shoulder Pain and Disability Index (SPADI), along with shoulder ROM (flexion, extension, abduction, adduction, and internal/external rotation). Linear regression models were used to evaluate associations between leptin, HOMA, and clinical outcomes, adjusting for potential confounders such as age and sex.METHODSThis cross-sectional study included 34 patients diagnosed with FS. Leptin and HOMA levels were measured and analysed in relation to pain and disability scores, as assessed by the Shoulder Pain and Disability Index (SPADI), along with shoulder ROM (flexion, extension, abduction, adduction, and internal/external rotation). Linear regression models were used to evaluate associations between leptin, HOMA, and clinical outcomes, adjusting for potential confounders such as age and sex.Higher leptin levels were significantly associated with increased SPADI pain (R2 = 0.114, β = 0.397, p = 0.005) and disability scores (R2 = 0.110, β = 0.425, p = 0.006), as well as an inverse association with shoulder flexion (R2 = 0.074, β = -1.088, p = 0.025), indicating reduced ROM with higher leptin levels. Similarly, higher HOMA levels were associated with increased SPADI pain (R2 = 0.096, β = 1.078, p = 0.010) and disability scores (R2 = 0.081, β = 1.517, p = 0.017), as well as combined SPADI scores (R2 = 0.089, β = 2.595, p = 0.014). HOMA also showed a significant inverse relationship with shoulder flexion (R2 = 0.061, β = -2.097, p = 0.028), suggesting that insulin resistance may contribute to ROM limitations.RESULTSHigher leptin levels were significantly associated with increased SPADI pain (R2 = 0.114, β = 0.397, p = 0.005) and disability scores (R2 = 0.110, β = 0.425, p = 0.006), as well as an inverse association with shoulder flexion (R2 = 0.074, β = -1.088, p = 0.025), indicating reduced ROM with higher leptin levels. Similarly, higher HOMA levels were associated with increased SPADI pain (R2 = 0.096, β = 1.078, p = 0.010) and disability scores (R2 = 0.081, β = 1.517, p = 0.017), as well as combined SPADI scores (R2 = 0.089, β = 2.595, p = 0.014). HOMA also showed a significant inverse relationship with shoulder flexion (R2 = 0.061, β = -2.097, p = 0.028), suggesting that insulin resistance may contribute to ROM limitations.Elevated leptin and insulin resistance levels were linked to greater pain, disability, and decreased ROM in patients with FS. These findings underscore the potential role of metabolic and inflammatory pathways in FS pathogenesis and highlight the importance of considering lifestyle interventions targeting leptin and insulin regulation as adjuncts to traditional management strategies for this condition.CONCLUSIONElevated leptin and insulin resistance levels were linked to greater pain, disability, and decreased ROM in patients with FS. These findings underscore the potential role of metabolic and inflammatory pathways in FS pathogenesis and highlight the importance of considering lifestyle interventions targeting leptin and insulin regulation as adjuncts to traditional management strategies for this condition.Elevated levels of leptin and HOMA (insulin resistance) are significantly associated with increased pain and disability in patients with frozen shoulder, as measured by SPADI scores. Higher leptin and HOMA levels are also associated with reduced range of motion, particularly in shoulder flexion. Targeting metabolic and inflammatory markers such as leptin and insulin resistance could inform new therapeutic approaches for managing frozen shoulder, with potential implications for treatment strategies in other inflammatory musculoskeletal conditions.SIGNIFICANCE STATEMENTElevated levels of leptin and HOMA (insulin resistance) are significantly associated with increased pain and disability in patients with frozen shoulder, as measured by SPADI scores. Higher leptin and HOMA levels are also associated with reduced range of motion, particularly in shoulder flexion. Targeting metabolic and inflammatory markers such as leptin and insulin resistance could inform new therapeutic approaches for managing frozen shoulder, with potential implications for treatment strategies in other inflammatory musculoskeletal conditions. To investigate the relationship between leptin levels, insulin resistance (measured by HOMA), and clinical outcomes related to pain, disability, and shoulder range of motion (ROM) in patients with frozen shoulder (FS). This cross-sectional study included 34 patients diagnosed with FS. Leptin and HOMA levels were measured and analysed in relation to pain and disability scores, as assessed by the Shoulder Pain and Disability Index (SPADI), along with shoulder ROM (flexion, extension, abduction, adduction, and internal/external rotation). Linear regression models were used to evaluate associations between leptin, HOMA, and clinical outcomes, adjusting for potential confounders such as age and sex. Higher leptin levels were significantly associated with increased SPADI pain (R = 0.114, β = 0.397, p = 0.005) and disability scores (R = 0.110, β = 0.425, p = 0.006), as well as an inverse association with shoulder flexion (R = 0.074, β = -1.088, p = 0.025), indicating reduced ROM with higher leptin levels. Similarly, higher HOMA levels were associated with increased SPADI pain (R = 0.096, β = 1.078, p = 0.010) and disability scores (R = 0.081, β = 1.517, p = 0.017), as well as combined SPADI scores (R = 0.089, β = 2.595, p = 0.014). HOMA also showed a significant inverse relationship with shoulder flexion (R = 0.061, β = -2.097, p = 0.028), suggesting that insulin resistance may contribute to ROM limitations. Elevated leptin and insulin resistance levels were linked to greater pain, disability, and decreased ROM in patients with FS. These findings underscore the potential role of metabolic and inflammatory pathways in FS pathogenesis and highlight the importance of considering lifestyle interventions targeting leptin and insulin regulation as adjuncts to traditional management strategies for this condition. Elevated levels of leptin and HOMA (insulin resistance) are significantly associated with increased pain and disability in patients with frozen shoulder, as measured by SPADI scores. Higher leptin and HOMA levels are also associated with reduced range of motion, particularly in shoulder flexion. Targeting metabolic and inflammatory markers such as leptin and insulin resistance could inform new therapeutic approaches for managing frozen shoulder, with potential implications for treatment strategies in other inflammatory musculoskeletal conditions. ABSTRACT Objective To investigate the relationship between leptin levels, insulin resistance (measured by HOMA), and clinical outcomes related to pain, disability, and shoulder range of motion (ROM) in patients with frozen shoulder (FS). Methods This cross‐sectional study included 34 patients diagnosed with FS. Leptin and HOMA levels were measured and analysed in relation to pain and disability scores, as assessed by the Shoulder Pain and Disability Index (SPADI), along with shoulder ROM (flexion, extension, abduction, adduction, and internal/external rotation). Linear regression models were used to evaluate associations between leptin, HOMA, and clinical outcomes, adjusting for potential confounders such as age and sex. Results Higher leptin levels were significantly associated with increased SPADI pain (R2 = 0.114, β = 0.397, p = 0.005) and disability scores (R2 = 0.110, β = 0.425, p = 0.006), as well as an inverse association with shoulder flexion (R2 = 0.074, β = −1.088, p = 0.025), indicating reduced ROM with higher leptin levels. Similarly, higher HOMA levels were associated with increased SPADI pain (R2 = 0.096, β = 1.078, p = 0.010) and disability scores (R2 = 0.081, β = 1.517, p = 0.017), as well as combined SPADI scores (R2 = 0.089, β = 2.595, p = 0.014). HOMA also showed a significant inverse relationship with shoulder flexion (R2 = 0.061, β = −2.097, p = 0.028), suggesting that insulin resistance may contribute to ROM limitations. Conclusion Elevated leptin and insulin resistance levels were linked to greater pain, disability, and decreased ROM in patients with FS. These findings underscore the potential role of metabolic and inflammatory pathways in FS pathogenesis and highlight the importance of considering lifestyle interventions targeting leptin and insulin regulation as adjuncts to traditional management strategies for this condition. Significance Statement Elevated levels of leptin and HOMA (insulin resistance) are significantly associated with increased pain and disability in patients with frozen shoulder, as measured by SPADI scores. Higher leptin and HOMA levels are also associated with reduced range of motion, particularly in shoulder flexion. Targeting metabolic and inflammatory markers such as leptin and insulin resistance could inform new therapeutic approaches for managing frozen shoulder, with potential implications for treatment strategies in other inflammatory musculoskeletal conditions. |
| Author | Navarro‐Ledesma, Santiago Pérez‐Montilla, José Javier Guzmán‐García, Rafael Pruimboom, Leo |
| Author_xml | – sequence: 1 givenname: José Javier orcidid: 0009-0008-1552-775X surname: Pérez‐Montilla fullname: Pérez‐Montilla, José Javier organization: University of Granada – sequence: 2 givenname: Rafael surname: Guzmán‐García fullname: Guzmán‐García, Rafael organization: University of Granada – sequence: 3 givenname: Leo surname: Pruimboom fullname: Pruimboom, Leo organization: University of Granada – sequence: 4 givenname: Santiago orcidid: 0000-0002-4302-1106 surname: Navarro‐Ledesma fullname: Navarro‐Ledesma, Santiago email: snl@ugr.es organization: University of Granada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40067138$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kc1OAjEUhRujEUEXvoDpUhcD7XTslJUx_CiGRBJIXDadzp1QUmZwOqPiykfwGX0Si8DG6Kq3N985ybmniQ7zIgeEzilpU0LCDixW7ZgQEh-gE3rNwiCkUffQz6RLAiYIbaCmcwtPRDFhx6gREcJjysQJeusX4PAYVpXJscpTPMpdbf08hhewzn8zW0OuAU_UjugbpxJjTbXGfjOtkwXoyuEnU83xsCzewS_nRW1TKG_wLe6VhXNfH59TT5kiVxZPqzpdn6KjTFkHZ7u3hWbDwax3H4wf70a923GgGQ_jgPKQxEJQzbupZopznkQq05pRkogs4ZnyUZXOGI1SkYgko9CNlNY0AqGFYC10ubVdlcVzDa6SS-M0WKtyKGonGY05iwhnzKMXO7ROlpDKVWmWqlzL_bE80NkCehOphExqU6lNqKpUxkpK5KYO6euQP3V4xdUvxd70L3bn_mosrP8H5eBhslV8A4Z9mo0 |
| CitedBy_id | crossref_primary_10_1016_j_msksp_2025_103417 crossref_primary_10_1186_s12891_025_08706_9 crossref_primary_10_3390_biomedicines13092117 crossref_primary_10_3390_jcm14134539 |
| Cites_doi | 10.1002/pri.2056 10.1016/j.msksp.2024.102980 10.1093/rheumatology/keae176 10.1177/03635465231189797 10.1093/rheumatology/keu272 10.4066/AMJ.2015.2293 10.3390/ijerph19042468 10.3390/cancers16030656 10.1186/s12891‐020‐03665‐9 10.3389/fphys.2024.1248612 10.1186/s12955‐015‐0397‐z 10.1210/jc.2017‐02772 10.3390/nu14071388 10.1016/j.numecd.2022.05.021 10.1159/000357230 10.1007/978-3-031-73061-0_16 10.3389/fmed.2021.663703 10.1016/S1836‐9553(11)70045‐5 10.1186/1471‐2474‐9‐161 10.4103/sja.SJA_543_18 10.3390/healthcare12232444 10.1001/jamanetworkopen.2020.29581 10.3390/biomedicines12112539 10.3390/life12101588 10.3390/ijerph19106228 10.3390/ijerph19074240 10.3390/ijerph19116698 10.2144/fsoa‐2020‐0145 10.1038/s41467‐024‐45341‐9 10.1093/pm/pnz022 10.1371/journal.pone.0288730 |
| ContentType | Journal Article |
| Copyright | 2025 European Pain Federation ‐ EFIC ®. |
| Copyright_xml | – notice: 2025 European Pain Federation ‐ EFIC ®. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1002/ejp.70007 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1532-2149 |
| EndPage | n/a |
| ExternalDocumentID | 40067138 10_1002_ejp_70007 EJP70007 |
| Genre | researchArticle Journal Article |
| GroupedDBID | --- --K .Y3 05W 0R~ 1B1 1OC 1~5 31~ 33P 3SF 4.4 4G. 50Y 50Z 52U 52V 53G 5GY 5VS 6PF 7-5 71M 8-0 8-1 930 A01 A04 AABNK AAEDT AAESR AAEVG AAHHS AAHQN AAIPD AALRI AAMNL AANHP AANLZ AAONW AAQXK AASGY AAWTL AAXRX AAXUO AAYCA AAZKR ABCUV ABIVO ABJNI ABOCM ABPVW ABQWH ABWVN ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACRPL ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADMUD ADNMO ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AEKER AENEX AEQDE AEUYR AFBPY AFFPM AFGKR AFWVQ AFZJQ AHBTC AIACR AIAGR AITUG AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BRXPI C45 CAG COF CS3 DCZOG DPXWK DRFUL DRMAN DRSTM DU5 EBD EBS EJD EMOBN EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FNPLU FUBAC G-Q G-S GODZA H.X HGLYW HVGLF HZ~ IHE J5H KBYEO LATKE LEEKS LITHE LOXES LUTES LYRES M41 MEWTI MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N06 N9A NF~ NQ- O66 O9- OG. OVD OZT P2P P2W Q.N QB0 R.K R2- RIG ROL RPZ RX1 SCC SDG SSZ SUPJJ SV3 TEORI UHS WBKPD WHWMO WIH WIJ WIK WOHZO WVDHM WXSBR YCJ ZZTAW ~WP 9DU AAMMB AAYXX AEFGJ AEYWJ AGHNM AGQPQ AGXDD AGYGG AIDQK AIDYY AIGII CITATION LH4 O8X ~HD CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c3627-16207881c69dc3a666b4afcc310b8fb6fa149acf314d8b8bf1e94acc14e8c883 |
| IEDL.DBID | DRFUL |
| ISICitedReferencesCount | 6 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001441398800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1090-3801 1532-2149 |
| IngestDate | Thu Oct 02 04:04:36 EDT 2025 Mon Sep 15 04:48:11 EDT 2025 Sat Nov 29 08:05:17 EST 2025 Tue Nov 18 22:16:51 EST 2025 Tue Mar 18 09:40:36 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | frozen shoulder shoulder pain inflammation insulin resistance leptin disability |
| Language | English |
| License | 2025 European Pain Federation ‐ EFIC ®. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3627-16207881c69dc3a666b4afcc310b8fb6fa149acf314d8b8bf1e94acc14e8c883 |
| Notes | The authors received no specific funding for this study. Funding ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-4302-1106 0009-0008-1552-775X |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ejp.70007 |
| PMID | 40067138 |
| PQID | 3176340633 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_3176340633 pubmed_primary_40067138 crossref_citationtrail_10_1002_ejp_70007 crossref_primary_10_1002_ejp_70007 wiley_primary_10_1002_ejp_70007_EJP70007 |
| PublicationCentury | 2000 |
| PublicationDate | April 2025 2025-04-00 2025-Apr 20250401 |
| PublicationDateYYYYMMDD | 2025-04-01 |
| PublicationDate_xml | – month: 04 year: 2025 text: April 2025 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | European journal of pain |
| PublicationTitleAlternate | Eur J Pain |
| PublicationYear | 2025 |
| References | 2015; 13 2021; 8 2024b; 15 2023; 51 2023; 18 2019; 13 2018; 103 2024; 72 2008; 9 2011; 57 2024; 12 2024 2024; 15 2015; 8 2013; 6 2020; 6 2020; 3 2022; 12 2024a; 16 2024; 63 2022; 14 2022; 32 2020; 21 2024; 29 2022; 19 2014; 53 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_24_1 e_1_2_8_25_1 e_1_2_8_26_1 e_1_2_8_27_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_21_1 e_1_2_8_22_1 e_1_2_8_23_1 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_14_1 e_1_2_8_15_1 e_1_2_8_16_1 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_11_1 e_1_2_8_12_1 e_1_2_8_30_1 |
| References_xml | – volume: 29 issue: 1 year: 2024 article-title: Does the Psychological Profile of a Patient With Frozen Shoulder Predict Future Outcome? A Systematic Review publication-title: Physiotherapy Research International – volume: 19 issue: 7 year: 2022 article-title: Efficacy of Nutritional Strategies on the Improvement of the Performance and Health of the Athlete: A Systematic Review publication-title: International Journal of Environmental Research and Public Health – volume: 9 start-page: 1 year: 2008 end-page: 8 article-title: Responsiveness of the Shoulder Pain and Disability Index in Patients With Adhesive Capsulitis publication-title: BMC Musculoskeletal Disorders – volume: 8 start-page: 1 year: 2021 end-page: 10 article-title: A Comprehensive View of Frozen Shoulder: A Mystery Syndrome publication-title: Frontiers in Medicine – volume: 57 start-page: 197 issue: 3 year: 2011 article-title: Shoulder Pain and Disability Index (SPADI) publication-title: Journal of Physiotherapy – volume: 14 issue: 7 year: 2022 article-title: Obesity and Leptin Resistance in the Regulation of the Type I Interferon Early Response and the Increased Risk for Severe COVID‐19 publication-title: Nutrients – volume: 32 start-page: 2026 issue: 9 year: 2022 end-page: 2040 article-title: A Comprehensive Overview on the Effects of Green Tea on Anthropometric Measures, Blood Pressure, Glycemic and Lipidemic Status: An Umbrella Review and Meta Meta‐Analysis Study publication-title: Nutrition, Metabolism, and Cardiovascular Diseases – volume: 12 issue: 11 year: 2024 article-title: The Role of Insulin Within the Socio‐Psycho‐Biological Framework in Type 2 Diabetes—A Perspective From Psychoneuroimmunology publication-title: Biomedicine – volume: 3 issue: 12 year: 2020 article-title: Comparison of Treatments for Frozen Shoulder: A Systematic Review and Meta‐Analysis publication-title: JAMA Network Open – volume: 12 issue: 23 year: 2024 article-title: Relationship Between Metabolic Profile, Pain, and Functionality in Patients With Frozen Shoulder: A Cross‐Sectional Study publication-title: Health – volume: 8 start-page: 113 issue: 4 year: 2015 end-page: 120 article-title: Muscular Strength, Aerobic Capacity, and Adipocytokines in Obese Youth After Resistance Training: A Pilot Study publication-title: Australasian Medical Journal – volume: 6 issue: 10 year: 2020 article-title: Frozen Shoulder: Overview of Clinical Presentation and Review of the Current Evidence Base for Management Strategies publication-title: Future Science OA – volume: 21 start-page: 1 issue: 1 year: 2020 end-page: 9 article-title: Shoulder Range of Movement in the General Population: Age and Gender Stratified Normative Data Using a Community‐Based Cohort publication-title: BMC Musculoskeletal Disorders – volume: 19 issue: 4 year: 2022 article-title: Patellar and Achilles Tendon Thickness Differences Among Athletes With Different Numbers of Meals per Day: A Cross‐Sectional Study publication-title: International Journal of Environmental Research and Public Health – year: 2024 – volume: 19 issue: 10 year: 2022 article-title: Causes of Shoulder Dysfunction in Diabetic Patients: A Review of Literature publication-title: International Journal of Environmental Research and Public Health – volume: 19 start-page: 1 issue: 11 year: 2022 end-page: 22 article-title: The Effectiveness of Intermittent Fasting, Time Restricted Feeding, Caloric Restriction, a Ketogenic Diet and the Mediterranean Diet as Part of the Treatment Plan to Improve Health and Chronic Musculoskeletal Pain: A Systematic Review publication-title: International Journal of Environmental Research and Public Health – volume: 13 start-page: 31 issue: 5 year: 2019 end-page: 34 article-title: The STROBE Guidelines publication-title: Saudi Journal of Anaesthesia – volume: 63 start-page: 3221 issue: 12 year: 2024 end-page: 3233 article-title: Pharmacological Interventions for Early‐Stage Frozen Shoulder: A Systematic Review and Network Meta‐Analysis publication-title: Rheumatology – volume: 12 issue: 10 year: 2022 article-title: Decreased Expression of Leptin Among Patients With Shoulder Stiffness publication-title: Lifestyles – volume: 103 start-page: 2522 issue: 7 year: 2018 end-page: 2533 article-title: Homeostasis Model Assessment of Insulin Resistance and Survival in Patients With Diabetes and Acute Coronary Syndrome publication-title: Journal of Clinical Endocrinology and Metabolism – volume: 51 start-page: 3261 issue: 12 year: 2023 end-page: 3267 article-title: Increased Expression of Adipokines in Patients With Frozen Shoulder publication-title: American Journal of Sports Medicine – volume: 15 year: 2024b article-title: A New Perspective of Frozen Shoulder Pathology; the Interplay Between the Brain and the Immune System publication-title: Frontiers in Physiology – volume: 15 issue: 1 year: 2024 article-title: A Single Cell Atlas of Frozen Shoulder Capsule Identifies Features Associated With Inflammatory Fibrosis Resolution publication-title: Nature Communications – volume: 18 issue: 11 year: 2023 article-title: Reduction of Leptin Levels During Acute Exercise Is Dependent on Fasting but Not on Caloric Restriction During Chronic Exercise: A Systematic Review and Meta‐Analysis publication-title: PLoS One – volume: 53 start-page: 2238 issue: 12 year: 2014 end-page: 2242 article-title: Adipokines as Predictors of Recovery From Upper Extremity Soft Tissue Disorders publication-title: Rheumatology (Oxford, England) – volume: 16 issue: 3 year: 2024a article-title: Physical Activity, Insulin Resistance and Cancer: A Systematic Review publication-title: Cancers – volume: 21 start-page: 150 issue: 1 year: 2020 end-page: 160 article-title: The Effect of Low‐Carbohydrate and Low‐Fat Diets on Pain in Individuals With Knee Osteoarthritis publication-title: Pain Medicine (United States) – volume: 13 start-page: 1 issue: 1 year: 2015 end-page: 6 article-title: Shoulder Pain and Disability Index: Cross Cultural Validation and Evaluation of Psychometric Properties of the Spanish Version publication-title: Health and Quality of Life Outcomes – volume: 6 start-page: 536 issue: 6 year: 2013 end-page: 541 article-title: Obesity‐Related Adipokines Predict Patient‐Reported Shoulder Pain publication-title: Obesity Facts – volume: 72 year: 2024 article-title: Differences in Biomechanical and Metabolic Factors Between Patients With Frozen Shoulder and Asymptomatic Individuals. A Cross‐Sectional Study publication-title: Musculoskeletal Science & Practice – ident: e_1_2_8_4_1 doi: 10.1002/pri.2056 – ident: e_1_2_8_16_1 doi: 10.1016/j.msksp.2024.102980 – ident: e_1_2_8_2_1 doi: 10.1093/rheumatology/keae176 – ident: e_1_2_8_25_1 doi: 10.1177/03635465231189797 – ident: e_1_2_8_26_1 doi: 10.1093/rheumatology/keu272 – ident: e_1_2_8_27_1 doi: 10.4066/AMJ.2015.2293 – ident: e_1_2_8_18_1 doi: 10.3390/ijerph19042468 – ident: e_1_2_8_19_1 doi: 10.3390/cancers16030656 – ident: e_1_2_8_12_1 doi: 10.1186/s12891‐020‐03665‐9 – ident: e_1_2_8_20_1 doi: 10.3389/fphys.2024.1248612 – ident: e_1_2_8_15_1 doi: 10.1186/s12955‐015‐0397‐z – ident: e_1_2_8_28_1 doi: 10.1210/jc.2017‐02772 – ident: e_1_2_8_17_1 doi: 10.3390/nu14071388 – ident: e_1_2_8_21_1 doi: 10.1016/j.numecd.2022.05.021 – ident: e_1_2_8_11_1 doi: 10.1159/000357230 – ident: e_1_2_8_24_1 doi: 10.1007/978-3-031-73061-0_16 – ident: e_1_2_8_9_1 doi: 10.3389/fmed.2021.663703 – ident: e_1_2_8_3_1 doi: 10.1016/S1836‐9553(11)70045‐5 – ident: e_1_2_8_31_1 doi: 10.1186/1471‐2474‐9‐161 – ident: e_1_2_8_7_1 doi: 10.4103/sja.SJA_543_18 – ident: e_1_2_8_13_1 doi: 10.3390/healthcare12232444 – ident: e_1_2_8_5_1 doi: 10.1001/jamanetworkopen.2020.29581 – ident: e_1_2_8_32_1 doi: 10.3390/biomedicines12112539 – ident: e_1_2_8_14_1 doi: 10.3390/life12101588 – ident: e_1_2_8_30_1 doi: 10.3390/ijerph19106228 – ident: e_1_2_8_23_1 doi: 10.3390/ijerph19074240 – ident: e_1_2_8_6_1 doi: 10.3390/ijerph19116698 – ident: e_1_2_8_8_1 doi: 10.2144/fsoa‐2020‐0145 – ident: e_1_2_8_22_1 doi: 10.1038/s41467‐024‐45341‐9 – ident: e_1_2_8_29_1 doi: 10.1093/pm/pnz022 – ident: e_1_2_8_10_1 doi: 10.1371/journal.pone.0288730 |
| SSID | ssj0004703 |
| Score | 2.4670193 |
| Snippet | ABSTRACT
Objective
To investigate the relationship between leptin levels, insulin resistance (measured by HOMA), and clinical outcomes related to pain,... To investigate the relationship between leptin levels, insulin resistance (measured by HOMA), and clinical outcomes related to pain, disability, and shoulder... |
| SourceID | proquest pubmed crossref wiley |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | e70007 |
| SubjectTerms | Adult Aged Bursitis - blood Bursitis - complications Bursitis - physiopathology Cross-Sectional Studies disability Disability Evaluation Female frozen shoulder Humans inflammation Insulin - blood insulin resistance Insulin Resistance - physiology leptin Leptin - blood Male Middle Aged Pain Measurement Range of Motion, Articular - physiology shoulder pain Shoulder Pain - blood Shoulder Pain - physiopathology |
| Title | Does Leptin and Insulin Levels Influence Pain and Disability in Subjects With Frozen Shoulder? A Cross‐Sectional Study |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fejp.70007 https://www.ncbi.nlm.nih.gov/pubmed/40067138 https://www.proquest.com/docview/3176340633 |
| Volume | 29 |
| WOSCitedRecordID | wos001441398800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1532-2149 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0004703 issn: 1090-3801 databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwEB7RBVVcePW15SGDOPSSkodxvOKAEMuqIEAroOreIr8iQFUWbRYEPfET-I38Emac7CJEK1XillgTy_HMeMb2zDcA6y7c1IpT5i9uPgIuLA-U1Zbu4NE4q1wYaXyxifT4WPZ6re4EbI1yYSp8iPGBG2mGX69JwZUuN55BQ93l1fc09JnkkzHK7WYDJtsnnZ-Hz2mRaVjF17cIQjaMRsBCYbwx_vilOXrlY750Wb3N6cy-abRzMFO7mmynko15mHDFArw_qi_TP8Btu-9KdkhhLQVThWX7VVw6Nt2gxcTXun4J66qaol0j8g7vGLbgokOnOCX7dTE8Z51B_4_DxnMqmu0G22yH7dI_P94_nPp4LxoMhS3efYSzzt7Z7o-gLsQQGLRvaRCJOCTYeSNa1iQKdzyaq9wYdA21zLXIFe6zlMmTiFuppc4j1-LKmIg7aaRMPkGj6BfuCzBrJK6nNoxMKriQsRJ5nuowsjHlxSWqCd9G7MhMDVJOtTJ-ZxW8cpzhRGZ-IpuwNia9qpA5_ka0OuJphnpDlyGqcP3rMkO_SSTozSRJEz5XzB53w8mGR4nE0Xie_rv_bO-g6x--_j_pIkzHVETYh_8sQWM4uHbLMGVuhhflYAXepT25UovyE_AT9nY |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1fT9swED8hOsFeYPzv2IaHeOAlkD_GcSWkCVEq2EpVQRG8RY7tCCaUVm1BY0_7CHxGPgl3TlqEAAlpb4l1sRzf2Xdn3_0OYMP6O6nilPmLzofHheGeMqmhO3hUzioTWmpXbCJuteTFRa09AbujXJgCH2J84EYrw-3XtMDpQHr7CTXU_u5txb5LJa9wFCOU70r9pHHWfMqLjP0iwL5GGLJ-MEIW8sPt8cfP9dELI_O5zeqUTmP2_4b7CWZKY5PtFdIxBxM2n4ep4_I6fQH-1Lt2wJoU2JIzlRt2VESmY9Mt6kx8LSuYsLYqKeolJu_wjmELbjt0jjNg51fDS9bod_9abLykstm2_4PtsX366Yd_96cu4osGQ4GLd4vQaRx09g-9shSDp1HDxV4gQp-A57WoGR0p9HlSrjKt0ThMZZaKTKGnpXQWBdzIVKZZYGtcaR1wK7WU0RJM5t3crgAzWuKOavxAx4ILGSqRZXHqByakzLhIVWFzxI9ElzDlVC3jOikAlsMEJzJxE1mF9TFpr8DmeI3o-4ipCa4cug5Rue3eDBK0nESE9kwUVWG54Pa4G05aPIgkjsYx9e3-k4Ofbffw-f2kazB92DluJs2j1q9V-BhSSWEXDPQFJof9G_sVPujb4dWg_62U6EffG_l- |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dSxwxEB_kLOJLtR_aU9vG0gdftu5HzOZAEPFcqp7HUS31bcnmAxXZO-5OUZ_6J_Rv9C9xJrt3Im2h0LfdMBuymSQzSWZ-P4DPNtwqFKfMX9x8BFwYHihTGLqDR-OsnNBSe7KJtNuVZ2et3gxsT3JhKnyI6YEbzQy_XtMEtwPjNp9QQ-3l4Esa-lTyWU4kMg2YbX_Lvnee8iLTsAqwbxGGbBhNkIXCeHP68XN79JuT-dxn9UYnW_i_5i7Cy9rZZLvV6HgFM7Z8DXPH9XX6G7ht9-2IdSiwpWSqNOygikzHohu0mfhaM5iwnqol2jUm7_iOYQkuO3SOM2I_LsbnLBv27y0WnhNtth3usF22Rz_98PPXiY_4osZQ4OLdWzjN9k_3vgY1FUOg0cKlQSTikIDntWgZnSjc8xRcOa3ROSykK4RTuNNS2iURN7KQhYtsiyutI26lljJZgkbZL-07YEZLXFFNGOlUcCFjJZxLizAyMWXGJaoJGxN95LqGKSe2jKu8AliOc-zI3HdkEz5NRQcVNsefhNYnSs1x5tB1iCpt_3qUo-ckEvRnkqQJy5W2p9VwsuJRIrE1Xql_rz_fP-z5h5V_F_0Ic712lncOukerMB8To7CPBVqDxnh4bd_DC30zvhgNP9QD-hF0evj5 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Does+Leptin+and+Insulin+Levels+Influence+Pain+and+Disability+in+Subjects+With+Frozen+Shoulder%3F+A+Cross%E2%80%90Sectional+Study&rft.jtitle=European+journal+of+pain&rft.au=P%C3%A9rez%E2%80%90Montilla%2C+Jos%C3%A9+Javier&rft.au=Guzm%C3%A1n%E2%80%90Garc%C3%ADa%2C+Rafael&rft.au=Pruimboom%2C+Leo&rft.au=Navarro%E2%80%90Ledesma%2C+Santiago&rft.date=2025-04-01&rft.issn=1090-3801&rft.eissn=1532-2149&rft.volume=29&rft.issue=4&rft_id=info:doi/10.1002%2Fejp.70007&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_ejp_70007 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1090-3801&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1090-3801&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1090-3801&client=summon |