Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause Parkinson's disease (PD) and therapies that reduce LRRK2 kinase activity are being tested in clinical trials. Numerous rare variants of unknown clinical significance have been reported, but how the vast majori...

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Bibliographische Detailangaben

Veröffentlicht in:	Biochemical journal Jg. 479; H. 17; S. 1759
Hauptverfasser:	Kalogeropulou, Alexia F, Purlyte, Elena, Tonelli, Francesca, Lange, Sven M, Wightman, Melanie, Prescott, Alan R, Padmanabhan, Shalini, Sammler, Esther, Alessi, Dario R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 16.09.2022
Schlagworte:	Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism Microtubules - metabolism Mutation Parkinson Disease - genetics Parkinson Disease - metabolism Phosphorylation Protein Binding leucine-rich repeat kinase Parkinson's disease signaling G-proteins
ISSN:	1470-8728, 1470-8728
Online-Zugang:	Weitere Angaben
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