Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause Parkinson's disease (PD) and therapies that reduce LRRK2 kinase activity are being tested in clinical trials. Numerous rare variants of unknown clinical significance have been reported, but how the vast majori...

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Vydané v:	Biochemical journal Ročník 479; číslo 17; s. 1759
Hlavní autori:	Kalogeropulou, Alexia F, Purlyte, Elena, Tonelli, Francesca, Lange, Sven M, Wightman, Melanie, Prescott, Alan R, Padmanabhan, Shalini, Sammler, Esther, Alessi, Dario R
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 16.09.2022
Predmet:	Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism Microtubules - metabolism Mutation Parkinson Disease - genetics Parkinson Disease - metabolism Phosphorylation Protein Binding leucine-rich repeat kinase Parkinson's disease signaling G-proteins
ISSN:	1470-8728, 1470-8728
On-line prístup:	Zistit podrobnosti o prístupe
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