Transforming growth factor-β in tissue fibrosis
TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-...
Saved in:
| Published in: | The Journal of experimental medicine Vol. 217; no. 3; p. e20190103 |
|---|---|
| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
02.03.2020
|
| ISSN: | 1540-9538, 1540-9538 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-β, some fibrogenic actions may reflect activation of other cell types, including macrophages, epithelial cells, and vascular cells. TGF-β-driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks. This review discusses the role of TGF-β in fibrosis, highlighting mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic translation.TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-β, some fibrogenic actions may reflect activation of other cell types, including macrophages, epithelial cells, and vascular cells. TGF-β-driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks. This review discusses the role of TGF-β in fibrosis, highlighting mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic translation. |
|---|---|
| AbstractList | TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-β, some fibrogenic actions may reflect activation of other cell types, including macrophages, epithelial cells, and vascular cells. TGF-β-driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks. This review discusses the role of TGF-β in fibrosis, highlighting mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic translation.TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-β, some fibrogenic actions may reflect activation of other cell types, including macrophages, epithelial cells, and vascular cells. TGF-β-driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks. This review discusses the role of TGF-β in fibrosis, highlighting mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic translation. |
| Author | Frangogiannis, Nikolaos |
| Author_xml | – sequence: 1 givenname: Nikolaos surname: Frangogiannis fullname: Frangogiannis, Nikolaos |
| BookMark | eNpNzL1OwzAUQGELFYm2sPEAGVlSruPrxB5RxZ9UiaXM1Y1rF1epDb6JeC8ehGdigIHpfNNZiFnKyQtxLWElweDt0Z9WDUgLEtSZmEuNUFutzOyfL8SC-QggEXU7F7AtlDjkcorpUB1K_hzfqkBuzKX-_qpiqsbIPPkqxL5kjnwpzgMN7K_-uhSvD_fb9VO9eXl8Xt9taqdaOdZeOdSBevIGrOsReiStOgpSOd0r1xqyDvQ--IC2AdfagMo51ek9WSLZLMXN7_e95I_J87g7RXZ-GCj5PPGuQeyMapUxzQ9wK0rK |
| CitedBy_id | crossref_primary_10_1007_s40744_024_00670_5 crossref_primary_10_1016_j_ajpath_2025_01_015 crossref_primary_10_1016_j_xfnr_2025_100089 crossref_primary_10_3390_ijms242216452 crossref_primary_10_1016_j_intimp_2024_113979 crossref_primary_10_1016_j_cyto_2024_156742 crossref_primary_10_3390_biom12101531 crossref_primary_10_1080_03639045_2024_2387814 crossref_primary_10_3390_ijms232314959 crossref_primary_10_1155_2023_3624635 crossref_primary_10_1038_s41598_024_63250_1 crossref_primary_10_1016_j_cytogfr_2025_05_007 crossref_primary_10_1172_jci_insight_191458 crossref_primary_10_1016_j_jid_2025_01_016 crossref_primary_10_1016_j_neuroscience_2021_12_038 crossref_primary_10_3389_fimmu_2022_829943 crossref_primary_10_1111_exd_14638 crossref_primary_10_1016_j_exer_2021_108829 crossref_primary_10_7759_cureus_42412 crossref_primary_10_1007_s43465_024_01294_1 crossref_primary_10_1007_s10522_025_10226_x crossref_primary_10_1016_j_ebiom_2024_105421 crossref_primary_10_1007_s11655_025_4130_4 crossref_primary_10_3389_fimmu_2022_1057932 crossref_primary_10_1164_rccm_202010_3832OC crossref_primary_10_1093_rb_rbad080 crossref_primary_10_1002_jcp_31465 crossref_primary_10_3390_biomedicines9091265 crossref_primary_10_1016_j_devcel_2024_07_012 crossref_primary_10_1016_j_biopha_2024_116298 crossref_primary_10_3390_healthcare9121687 crossref_primary_10_1016_j_mbs_2025_109375 crossref_primary_10_1172_JCI148554 crossref_primary_10_1016_j_addr_2021_113904 crossref_primary_10_3390_nu15010099 crossref_primary_10_1038_s41584_022_00864_7 crossref_primary_10_1186_s12885_025_14751_3 crossref_primary_10_1165_rcmb_2021_0484OC crossref_primary_10_1172_jci_insight_192890 crossref_primary_10_1016_j_molmet_2025_102179 crossref_primary_10_1093_rb_rbad099 crossref_primary_10_1016_j_bcp_2025_116959 crossref_primary_10_3390_cells13090764 crossref_primary_10_4062_biomolther_2025_023 crossref_primary_10_3390_ijms24097986 crossref_primary_10_1007_s11010_023_04659_6 crossref_primary_10_3390_molecules28020753 crossref_primary_10_1016_j_fct_2024_114731 crossref_primary_10_1631_jzus_B2200506 crossref_primary_10_1186_s12931_025_03218_5 crossref_primary_10_1016_j_biopha_2024_117470 crossref_primary_10_1155_2023_8821610 crossref_primary_10_3389_fimmu_2025_1551911 crossref_primary_10_1080_09553002_2022_1998711 crossref_primary_10_1016_j_jsps_2024_102092 crossref_primary_10_3390_ijms241914845 crossref_primary_10_1016_j_jcyt_2025_02_004 crossref_primary_10_1111_jpi_12958 crossref_primary_10_1016_j_biopha_2022_113236 crossref_primary_10_1007_s11302_023_09977_4 crossref_primary_10_1177_09603271241303320 crossref_primary_10_1007_s12033_023_00941_6 crossref_primary_10_3389_fimmu_2023_1264882 crossref_primary_10_3389_fnins_2022_917587 crossref_primary_10_1080_14686996_2023_2186690 crossref_primary_10_1016_j_jff_2023_105901 crossref_primary_10_1016_j_medj_2023_12_011 crossref_primary_10_1038_s41419_024_06756_w crossref_primary_10_3389_fimmu_2022_1021413 crossref_primary_10_1007_s12012_025_10025_3 crossref_primary_10_3389_fmed_2022_959010 crossref_primary_10_3390_ijms222111862 crossref_primary_10_3390_ijms22095050 crossref_primary_10_3389_fimmu_2025_1580108 crossref_primary_10_3389_fimmu_2025_1583616 crossref_primary_10_3390_bioengineering10121411 crossref_primary_10_3390_ijms22041985 crossref_primary_10_1038_s41420_023_01553_4 crossref_primary_10_1002_advs_202404151 crossref_primary_10_3389_fcimb_2022_1017040 crossref_primary_10_1007_s10787_024_01545_5 crossref_primary_10_1016_j_intimp_2025_115066 crossref_primary_10_1136_bmjinnov_2021_000717 crossref_primary_10_1177_20417314231185848 crossref_primary_10_1093_cvr_cvaa324 crossref_primary_10_3390_molecules29092107 crossref_primary_10_1126_scitranslmed_adm6783 crossref_primary_10_1002_cbdv_202401738 crossref_primary_10_12677_acm_2025_1592544 crossref_primary_10_1002_advs_202415032 crossref_primary_10_1038_s41598_023_41294_z crossref_primary_10_1016_j_cellsig_2025_111956 crossref_primary_10_1038_s41598_024_62123_x crossref_primary_10_3390_ijms25063288 crossref_primary_10_1038_s41467_022_28623_y crossref_primary_10_1038_s41598_022_15768_5 crossref_primary_10_1091_mbc_E23_07_0294 crossref_primary_10_3390_biom11040528 crossref_primary_10_1186_s12886_022_02249_6 crossref_primary_10_7759_cureus_89850 crossref_primary_10_3389_fimmu_2023_1196970 crossref_primary_10_1155_2024_5583961 crossref_primary_10_1371_journal_pone_0292684 crossref_primary_10_1007_s00210_022_02318_z crossref_primary_10_1016_j_bbadis_2023_166842 crossref_primary_10_1093_glycob_cwad062 crossref_primary_10_3390_ijms24108927 crossref_primary_10_3389_fphar_2022_911945 crossref_primary_10_1080_0886022X_2025_2459356 crossref_primary_10_1111_liv_16125 crossref_primary_10_3389_fmed_2023_1160755 crossref_primary_10_1002_adma_202417564 crossref_primary_10_3389_fnut_2022_807071 crossref_primary_10_3389_fphys_2022_814754 crossref_primary_10_3390_ijms24087614 crossref_primary_10_14712_fb2024070040219 crossref_primary_10_3390_ph18060812 crossref_primary_10_1080_14728214_2024_2340723 crossref_primary_10_1016_j_ijbiomac_2025_146564 crossref_primary_10_31083_j_fbl2712324 crossref_primary_10_1038_s41598_023_30783_w crossref_primary_10_1080_00498254_2025_2505066 crossref_primary_10_3389_fphar_2021_774316 crossref_primary_10_1038_s41598_025_05781_9 crossref_primary_10_3390_ani14010076 crossref_primary_10_1186_s13048_024_01448_7 crossref_primary_10_34133_bmr_0032 crossref_primary_10_1016_j_exer_2021_108803 crossref_primary_10_2340_actadv_v105_43088 crossref_primary_10_1186_s12891_021_04712_9 crossref_primary_10_3389_fcvm_2023_1142612 crossref_primary_10_1161_CIRCRESAHA_123_323360 crossref_primary_10_1002_hsr2_1100 crossref_primary_10_1038_s41551_025_01396_7 crossref_primary_10_3390_ijms26157156 crossref_primary_10_1016_j_cjca_2025_07_008 crossref_primary_10_1186_s13018_024_04733_9 crossref_primary_10_1038_s41419_021_04019_6 crossref_primary_10_3390_ijms222212341 crossref_primary_10_1007_s11103_023_01394_w crossref_primary_10_3390_cells12232698 crossref_primary_10_3390_ijms242216260 crossref_primary_10_3389_fonc_2023_1170893 crossref_primary_10_3389_fimmu_2021_689181 crossref_primary_10_3390_toxics11110910 crossref_primary_10_1016_j_cyto_2023_156285 crossref_primary_10_3390_ijms251910803 crossref_primary_10_1038_s41568_023_00578_2 crossref_primary_10_1016_j_psj_2025_105576 crossref_primary_10_1016_j_jep_2023_117396 crossref_primary_10_3390_ijms24032801 crossref_primary_10_1186_s13075_024_03340_7 crossref_primary_10_1038_s12276_022_00778_0 crossref_primary_10_1016_j_ijbiomac_2024_136596 crossref_primary_10_1159_000543275 crossref_primary_10_3389_fphar_2025_1560567 crossref_primary_10_1002_med4_10 crossref_primary_10_1165_rcmb_2021_0342TR crossref_primary_10_3389_fendo_2025_1557797 crossref_primary_10_3389_fmolb_2023_1132353 crossref_primary_10_3390_antiox12040794 crossref_primary_10_1016_j_biopha_2024_117150 crossref_primary_10_1016_j_gene_2022_147142 crossref_primary_10_1016_j_bbadva_2024_100132 crossref_primary_10_3390_ph16010114 crossref_primary_10_1016_j_jbc_2024_105691 crossref_primary_10_1016_j_jes_2025_03_029 crossref_primary_10_1186_s12951_024_02780_2 crossref_primary_10_1093_eurheartj_ehaf428 crossref_primary_10_15829_1728_8800_2023_3839 crossref_primary_10_1016_j_semcdb_2025_103642 crossref_primary_10_1016_j_biopha_2022_113438 crossref_primary_10_1038_s41598_024_78136_5 crossref_primary_10_3390_ph18081142 crossref_primary_10_3390_jcm12165287 crossref_primary_10_1016_j_jprot_2024_105287 crossref_primary_10_3389_fphar_2023_1192370 crossref_primary_10_3390_ijms24021019 crossref_primary_10_3389_fcvm_2023_1056134 crossref_primary_10_1016_j_heliyon_2023_e17613 crossref_primary_10_1038_s41385_021_00480_w crossref_primary_10_32388_X0TQ1D_6 crossref_primary_10_1183_13993003_01326_2023 crossref_primary_10_1016_j_autrev_2025_103899 crossref_primary_10_3390_jcm13216304 crossref_primary_10_7759_cureus_59246 crossref_primary_10_1016_j_biopha_2024_116568 crossref_primary_10_1080_03008207_2024_2319051 crossref_primary_10_1016_j_xcrp_2025_102795 crossref_primary_10_1038_s41598_024_82495_4 crossref_primary_10_1186_s12951_024_03047_6 crossref_primary_10_3389_fcell_2025_1641584 crossref_primary_10_31083_j_fbl2702038 crossref_primary_10_1016_j_vetpar_2025_110488 crossref_primary_10_3389_fped_2021_669116 crossref_primary_10_1111_wrr_12952 crossref_primary_10_1161_ATVBAHA_123_320326 crossref_primary_10_1021_acsptsci_5c00009 crossref_primary_10_3390_ijms23147967 crossref_primary_10_1016_j_atherosclerosis_2025_120480 crossref_primary_10_1016_j_jid_2023_11_019 crossref_primary_10_1016_j_exer_2024_110127 crossref_primary_10_1097_MOG_0000000000000729 crossref_primary_10_1161_CIRCRESAHA_121_320694 crossref_primary_10_1016_j_biopha_2024_116695 crossref_primary_10_3390_cells10113053 crossref_primary_10_1016_j_bbamcr_2020_118703 crossref_primary_10_1093_burnst_tkae023 crossref_primary_10_1016_j_isci_2025_113013 crossref_primary_10_1091_mbc_E24_01_0040 crossref_primary_10_1016_j_bcp_2024_116130 crossref_primary_10_3390_biom14111478 crossref_primary_10_1021_acs_jmedchem_5c01432 crossref_primary_10_14814_phy2_16032 crossref_primary_10_1093_cvr_cvae066 crossref_primary_10_1155_2021_9833142 crossref_primary_10_1007_s12013_025_01762_x crossref_primary_10_1007_s00210_024_03700_9 crossref_primary_10_3389_fimmu_2024_1232070 crossref_primary_10_1177_10711007231171075 crossref_primary_10_1186_s12903_025_05845_2 crossref_primary_10_3390_ijms24033016 crossref_primary_10_1096_fj_202101262R crossref_primary_10_1172_JCI171953 crossref_primary_10_3390_ijms222212262 crossref_primary_10_1016_j_biomaterials_2024_122558 crossref_primary_10_26508_lsa_202302055 crossref_primary_10_1007_s11356_025_36382_8 crossref_primary_10_1002_advs_202301505 crossref_primary_10_1007_s44164_025_00081_y crossref_primary_10_3390_ijms22062952 crossref_primary_10_3390_ijms222111575 crossref_primary_10_1002_med_21853 crossref_primary_10_3390_cells11071198 crossref_primary_10_1016_j_bcp_2024_116282 crossref_primary_10_1038_s41698_025_01066_6 crossref_primary_10_1007_s10238_022_00966_2 crossref_primary_10_1016_j_clim_2023_109695 crossref_primary_10_1016_j_exphem_2023_02_003 crossref_primary_10_3389_fphar_2022_906212 crossref_primary_10_1016_j_tice_2025_103032 crossref_primary_10_1016_j_jep_2025_119571 crossref_primary_10_26508_lsa_202201380 crossref_primary_10_3389_fimmu_2023_1219487 crossref_primary_10_3390_ijms23010171 crossref_primary_10_1002_ptr_7278 crossref_primary_10_1016_j_bioadv_2025_214410 crossref_primary_10_1186_s13287_025_04616_8 crossref_primary_10_1038_s41392_022_00972_6 crossref_primary_10_1016_j_bbr_2023_114683 crossref_primary_10_3390_ijms241310913 crossref_primary_10_1002_ctm2_1546 crossref_primary_10_1016_j_molmed_2025_03_009 crossref_primary_10_1002_jcp_31168 crossref_primary_10_1186_s12950_022_00324_9 crossref_primary_10_1038_s41598_021_98806_y crossref_primary_10_25122_jml_2022_0181 crossref_primary_10_1016_j_bcp_2024_116271 crossref_primary_10_1080_17460751_2025_2546758 crossref_primary_10_3390_cancers13071711 crossref_primary_10_1002_adhm_202303991 crossref_primary_10_3390_cells13040327 crossref_primary_10_3389_fcell_2021_671081 crossref_primary_10_3389_fphar_2024_1377113 crossref_primary_10_2174_0115733971293288240313090945 crossref_primary_10_1016_j_biopha_2021_112127 crossref_primary_10_1038_s41588_024_01819_2 crossref_primary_10_1186_s12967_024_05698_3 crossref_primary_10_1038_s41598_024_58239_9 crossref_primary_10_1016_j_bbamcr_2023_119548 crossref_primary_10_52711_0974_360X_2024_00921 crossref_primary_10_3390_molecules27154785 crossref_primary_10_1111_cpr_70096 crossref_primary_10_3390_ani13193153 crossref_primary_10_3390_nu16213633 crossref_primary_10_1152_ajprenal_00185_2025 crossref_primary_10_1186_s12951_022_01598_0 crossref_primary_10_1186_s12931_024_02876_1 crossref_primary_10_1016_j_ejphar_2023_176293 crossref_primary_10_1242_dmm_050733 crossref_primary_10_3389_fcell_2021_734749 crossref_primary_10_3390_molecules27196572 crossref_primary_10_1007_s12272_025_01542_4 crossref_primary_10_3390_plants12112096 crossref_primary_10_70322_fibrosis_2025_10008 crossref_primary_10_1038_s41598_022_08425_4 crossref_primary_10_1016_j_jpet_2025_103672 crossref_primary_10_3390_ijms26051961 crossref_primary_10_1002_adfm_202516289 crossref_primary_10_1096_fj_202400854R crossref_primary_10_1016_j_exer_2025_110566 crossref_primary_10_1038_s42003_022_03938_0 crossref_primary_10_3389_fimmu_2022_845956 crossref_primary_10_1016_j_jff_2025_106734 crossref_primary_10_1016_j_jbc_2024_107256 crossref_primary_10_1016_j_jep_2024_119229 crossref_primary_10_1016_j_archoralbio_2025_106362 crossref_primary_10_1016_j_jse_2025_06_009 crossref_primary_10_2174_0115743624339476250212114656 crossref_primary_10_1002_smll_202205012 crossref_primary_10_1164_rccm_202410_1934OC crossref_primary_10_1016_j_cophys_2020_10_004 crossref_primary_10_1161_CIRCRESAHA_121_318173 crossref_primary_10_1038_s41467_024_52068_0 crossref_primary_10_1038_s41401_024_01413_6 crossref_primary_10_1016_j_trsl_2024_04_003 crossref_primary_10_1155_sci_1416567 crossref_primary_10_1002_jcb_30629 crossref_primary_10_1002_advs_202500788 crossref_primary_10_1002_pro6_1241 crossref_primary_10_3389_fphar_2023_1183720 crossref_primary_10_1161_CIRCRESAHA_125_326758 crossref_primary_10_1016_j_pharmthera_2023_108528 crossref_primary_10_1096_fj_202201867R crossref_primary_10_1016_j_lfs_2023_122064 crossref_primary_10_3390_ijms23073521 crossref_primary_10_1183_20734735_0259_2024 crossref_primary_10_1186_s12931_025_03110_2 crossref_primary_10_1016_j_cellsig_2024_111355 crossref_primary_10_3390_antiox14040389 crossref_primary_10_1183_13993003_00498_2024 crossref_primary_10_1302_2046_3758_146_BJR_2024_0387_R3 crossref_primary_10_1038_s41598_024_79848_4 crossref_primary_10_7554_eLife_79543 crossref_primary_10_1002_advs_202405678 crossref_primary_10_1038_s41467_022_34776_7 crossref_primary_10_1002_anbr_202400148 crossref_primary_10_1186_s12967_024_05753_z crossref_primary_10_3390_biom11081095 crossref_primary_10_1111_bph_17392 crossref_primary_10_1016_j_phymed_2023_155078 crossref_primary_10_3390_biom14040412 crossref_primary_10_1016_j_jid_2023_10_045 crossref_primary_10_1186_s12967_024_05411_4 crossref_primary_10_1128_mbio_02562_24 crossref_primary_10_1016_j_ijbiomac_2025_144407 crossref_primary_10_25259_Cytojournal_32_2024 crossref_primary_10_3390_ijms22073644 crossref_primary_10_1038_s41467_023_37450_8 crossref_primary_10_1186_s12931_024_02898_9 crossref_primary_10_1038_s42003_025_08634_3 crossref_primary_10_2147_IJN_S347164 crossref_primary_10_1007_s43188_024_00269_6 crossref_primary_10_3389_fcell_2021_681061 crossref_primary_10_3390_biom15040509 crossref_primary_10_3390_ph18060859 crossref_primary_10_1016_j_wasman_2023_11_002 crossref_primary_10_1186_s12917_022_03202_x crossref_primary_10_1016_j_ejphar_2023_176088 crossref_primary_10_1186_s13014_025_02617_8 crossref_primary_10_1016_j_ejphar_2022_174977 crossref_primary_10_3389_fphar_2022_962525 crossref_primary_10_1016_j_nantod_2022_101559 crossref_primary_10_3390_biomedicines13081927 crossref_primary_10_1038_s41467_025_58906_z crossref_primary_10_1016_j_freeradbiomed_2023_11_036 crossref_primary_10_1007_s00210_023_02540_3 crossref_primary_10_1186_s40001_024_02122_w crossref_primary_10_1038_s41375_023_01878_0 crossref_primary_10_3390_biom13081179 crossref_primary_10_1172_JCI146926 crossref_primary_10_1186_s40634_022_00468_w crossref_primary_10_3390_ijms231910988 crossref_primary_10_1007_s00262_025_04103_2 crossref_primary_10_1016_j_cell_2021_11_033 crossref_primary_10_1038_s41598_023_30776_9 crossref_primary_10_1155_mi_6587305 crossref_primary_10_3389_fcell_2021_687117 crossref_primary_10_1002_adhm_202304572 crossref_primary_10_2147_JIR_S306073 crossref_primary_10_1038_s42003_023_05558_8 crossref_primary_10_1126_sciimmunol_abi4613 crossref_primary_10_1016_j_biopha_2022_112910 crossref_primary_10_1186_s10020_024_00815_w crossref_primary_10_3390_ph17101275 crossref_primary_10_1021_acs_jmedchem_4c02938 crossref_primary_10_1016_j_jnutbio_2023_109294 crossref_primary_10_1016_j_jbc_2023_105605 crossref_primary_10_1371_journal_pcbi_1011741 crossref_primary_10_3389_fendo_2023_1324429 crossref_primary_10_1016_j_radonc_2025_110744 crossref_primary_10_3390_ijms23052617 crossref_primary_10_1016_j_ejmech_2025_117768 crossref_primary_10_1186_s13020_025_01067_4 crossref_primary_10_3390_cells10092412 crossref_primary_10_3389_fmed_2024_1415278 crossref_primary_10_1016_j_jddst_2025_107533 crossref_primary_10_1016_j_thromres_2022_08_010 crossref_primary_10_1007_s11130_022_01009_7 crossref_primary_10_1016_j_bioactmat_2024_10_019 crossref_primary_10_1016_j_lfs_2025_123503 crossref_primary_10_1016_j_omton_2025_200945 crossref_primary_10_1177_11297298221085458 crossref_primary_10_2106_JBJS_RVW_23_00140 crossref_primary_10_3389_fmicb_2021_694967 crossref_primary_10_1038_s41375_021_01464_2 crossref_primary_10_3390_cells13010050 crossref_primary_10_1038_s41598_024_60945_3 crossref_primary_10_1186_s12964_024_01623_9 crossref_primary_10_3390_biomedicines12010216 crossref_primary_10_1016_j_biopha_2023_114258 crossref_primary_10_3390_ijms26020517 crossref_primary_10_1002_jcp_30818 crossref_primary_10_3390_biom14101277 crossref_primary_10_1016_j_ijpharm_2023_123644 crossref_primary_10_3390_ijms26189117 crossref_primary_10_1016_j_jhazmat_2024_134772 crossref_primary_10_1016_j_matbio_2021_10_005 crossref_primary_10_1186_s12929_024_01001_0 crossref_primary_10_1038_s41598_024_64364_2 crossref_primary_10_1016_j_biomaterials_2024_123009 crossref_primary_10_70322_jrbtm_2025_10001 crossref_primary_10_1007_s11357_024_01418_3 crossref_primary_10_2147_DDDT_S488226 crossref_primary_10_1016_j_biopha_2023_114481 crossref_primary_10_1016_j_pupt_2024_102285 crossref_primary_10_3390_biom15071050 crossref_primary_10_1158_0008_5472_CAN_21_0590 crossref_primary_10_1016_j_intimp_2024_112067 crossref_primary_10_1016_j_jcjp_2024_100174 crossref_primary_10_1096_fj_202302379R crossref_primary_10_1161_JAHA_124_037455 crossref_primary_10_1002_cbin_12097 crossref_primary_10_1016_j_jaut_2023_103122 crossref_primary_10_2147_JAA_S267222 crossref_primary_10_7759_cureus_18088 crossref_primary_10_1111_cea_14003 crossref_primary_10_1177_10406387251339813 crossref_primary_10_1016_j_chmed_2025_07_003 crossref_primary_10_1016_j_taap_2024_116939 crossref_primary_10_1515_tjb_2024_0093 crossref_primary_10_4330_wjc_v17_i5_106123 crossref_primary_10_1093_ckj_sfab175 crossref_primary_10_12688_f1000research_143472_1 crossref_primary_10_1007_s00335_023_10022_3 crossref_primary_10_1016_j_bcp_2023_115839 crossref_primary_10_1016_j_jep_2023_116558 crossref_primary_10_3389_fimmu_2024_1342895 crossref_primary_10_1016_j_intimp_2024_112298 crossref_primary_10_1038_s41569_021_00646_w crossref_primary_10_1016_j_biopha_2023_115448 crossref_primary_10_1016_j_jobcr_2024_03_005 crossref_primary_10_1016_j_heliyon_2024_e30512 crossref_primary_10_1016_j_psj_2025_104976 crossref_primary_10_1146_annurev_pathol_042320_030240 crossref_primary_10_1016_j_jtos_2023_05_005 crossref_primary_10_3389_fmed_2024_1370396 crossref_primary_10_1016_j_lfs_2025_123970 crossref_primary_10_1038_s41467_025_56448_y crossref_primary_10_1016_j_carbpol_2022_119134 crossref_primary_10_3389_fimmu_2023_1134634 crossref_primary_10_1002_eji_202350460 crossref_primary_10_1016_j_molmed_2024_11_012 crossref_primary_10_1016_j_exer_2021_108594 crossref_primary_10_1002_jbt_23215 crossref_primary_10_1016_j_bbadis_2020_166044 crossref_primary_10_1038_s41467_022_32655_9 crossref_primary_10_1002_art_42638 crossref_primary_10_3389_fphar_2023_1202676 crossref_primary_10_1002_cam4_71067 crossref_primary_10_1038_s41408_023_00947_y crossref_primary_10_1038_s42003_024_06419_8 crossref_primary_10_1097_CM9_0000000000003545 crossref_primary_10_1007_s10989_024_10595_w crossref_primary_10_3390_ijms24076172 crossref_primary_10_1016_j_bioorg_2021_105222 crossref_primary_10_3389_fimmu_2022_878876 crossref_primary_10_1016_j_bcp_2025_117036 crossref_primary_10_3390_metabo13030400 crossref_primary_10_1080_13880209_2025_2488994 crossref_primary_10_3389_froh_2023_1308657 crossref_primary_10_1186_s11658_024_00635_0 crossref_primary_10_3390_ijms25021276 crossref_primary_10_13005_bpj_2401 crossref_primary_10_2147_JIR_S502496 crossref_primary_10_3390_ijms252312864 crossref_primary_10_1016_j_tips_2025_06_002 crossref_primary_10_1111_wrr_70071 crossref_primary_10_7717_peerj_12797 crossref_primary_10_3390_ijms241310511 crossref_primary_10_1038_s41588_023_01526_4 crossref_primary_10_3390_biomedicines10071624 crossref_primary_10_1016_j_cellsig_2024_111190 crossref_primary_10_1016_j_intimp_2025_114472 crossref_primary_10_1016_j_jbc_2025_110203 crossref_primary_10_3390_cells10071742 crossref_primary_10_1007_s12016_021_08889_8 crossref_primary_10_1007_s12265_025_10630_1 crossref_primary_10_3390_medicina61091545 crossref_primary_10_1007_s10856_024_06836_5 crossref_primary_10_1016_j_ejphar_2022_174791 crossref_primary_10_3390_biology14070747 crossref_primary_10_4168_aair_2022_14_4_361 crossref_primary_10_1080_01902148_2022_2067265 crossref_primary_10_1002_jcb_30230 crossref_primary_10_1007_s11892_025_01590_6 crossref_primary_10_3390_ijms23095017 crossref_primary_10_2147_IJGM_S395705 crossref_primary_10_4236_fns_2025_169063 crossref_primary_10_3389_fimmu_2021_740260 crossref_primary_10_1016_j_biopha_2022_114080 crossref_primary_10_22467_jwmr_2025_03272 crossref_primary_10_1016_j_eurpolymj_2023_112364 crossref_primary_10_3390_biom11020336 crossref_primary_10_1111_wrr_70065 crossref_primary_10_3390_gels11070564 crossref_primary_10_1002_vms3_70098 crossref_primary_10_1016_j_molimm_2023_04_006 crossref_primary_10_1007_s12265_025_10679_y crossref_primary_10_1038_s12276_024_01170_w crossref_primary_10_1093_cvr_cvae210 crossref_primary_10_1002_art_42858 crossref_primary_10_12677_tcm_2024_134122 crossref_primary_10_1007_s00772_025_01191_3 crossref_primary_10_1371_journal_pone_0300809 crossref_primary_10_3390_cells14151191 crossref_primary_10_1016_j_abb_2024_110134 crossref_primary_10_1111_imr_13179 crossref_primary_10_3390_cancers14081947 crossref_primary_10_1016_j_chemosphere_2022_134633 crossref_primary_10_3390_ma14112806 crossref_primary_10_7554_eLife_94425 crossref_primary_10_3390_cancers16010081 crossref_primary_10_1093_asj_sjaf143 crossref_primary_10_21518_ms2025_031 crossref_primary_10_1016_j_anai_2022_10_026 crossref_primary_10_1093_biolre_ioad065 crossref_primary_10_1172_JCI177123 crossref_primary_10_1002_cbdv_202200704 crossref_primary_10_3389_fphar_2022_985223 crossref_primary_10_1016_j_ijpharm_2025_126121 crossref_primary_10_1016_j_biopha_2022_112906 crossref_primary_10_1016_j_micpath_2024_107236 crossref_primary_10_1016_j_pharmthera_2023_108460 crossref_primary_10_1016_j_jid_2025_05_023 crossref_primary_10_1016_j_nantod_2022_101719 crossref_primary_10_1016_j_phymed_2025_156498 crossref_primary_10_1016_j_cellsig_2020_109826 crossref_primary_10_3390_ijms26020813 crossref_primary_10_3892_ijmm_2022_5194 crossref_primary_10_7717_peerj_19040 crossref_primary_10_1007_s11033_025_10798_4 crossref_primary_10_1016_j_bbrc_2024_149686 crossref_primary_10_1186_s12987_022_00324_0 crossref_primary_10_1007_s40883_025_00476_z crossref_primary_10_1016_j_yjmcc_2022_07_006 crossref_primary_10_1021_acs_jmedchem_5c00133 crossref_primary_10_1039_D2BM00770C crossref_primary_10_1016_j_bbrc_2021_05_035 crossref_primary_10_1093_jbmrpl_ziaf079 crossref_primary_10_1016_j_bcp_2023_115644 crossref_primary_10_3390_pharmaceutics13050621 crossref_primary_10_1007_s00018_022_04236_y crossref_primary_10_1016_j_pharmthera_2025_108820 crossref_primary_10_1016_j_lfs_2024_122644 crossref_primary_10_3390_ph17030267 crossref_primary_10_1186_s40001_025_02996_4 crossref_primary_10_1016_j_jds_2023_05_029 crossref_primary_10_1186_s13071_022_05584_1 crossref_primary_10_1016_j_biopha_2023_114666 crossref_primary_10_3389_fphar_2021_762998 crossref_primary_10_1111_jcmm_18234 crossref_primary_10_3389_fimmu_2022_889175 crossref_primary_10_3390_genes15070934 crossref_primary_10_1016_j_jnha_2024_100285 crossref_primary_10_1038_s41569_021_00520_9 crossref_primary_10_1002_path_5680 crossref_primary_10_1002_mco2_744 crossref_primary_10_3390_ncrna8010013 crossref_primary_10_3390_cardiogenetics14040019 crossref_primary_10_1007_s12105_024_01701_x crossref_primary_10_7554_eLife_94425_3 crossref_primary_10_1016_j_lfs_2021_120070 crossref_primary_10_3390_ijms222011152 crossref_primary_10_58838_2075_1230_2025_103_3_79_87 crossref_primary_10_1093_nutrit_nuad133 crossref_primary_10_1186_s12967_025_06804_9 crossref_primary_10_3390_ijms25126650 crossref_primary_10_3390_vetsci12040330 crossref_primary_10_7554_eLife_57920 crossref_primary_10_1002_mco2_70063 crossref_primary_10_3389_fbioe_2024_1469238 crossref_primary_10_1016_j_actbio_2025_08_027 crossref_primary_10_1002_advs_202406398 crossref_primary_10_1038_s41598_025_96961_0 crossref_primary_10_1126_sciadv_ads7903 crossref_primary_10_3389_fneph_2025_1540471 crossref_primary_10_1002_fsn3_70677 crossref_primary_10_1016_j_bbadis_2024_167620 crossref_primary_10_1111_jre_13257 crossref_primary_10_1038_s41577_024_01087_5 crossref_primary_10_3390_biomedicines10092189 crossref_primary_10_1161_CIRCRESAHA_124_323660 crossref_primary_10_1016_j_gene_2025_149274 crossref_primary_10_1111_1440_1681_13823 crossref_primary_10_1158_1078_0432_CCR_24_1004 crossref_primary_10_1016_j_bbrc_2024_150523 crossref_primary_10_1093_lifemeta_load021 crossref_primary_10_1371_journal_pone_0310852 crossref_primary_10_3389_fimmu_2023_1159856 crossref_primary_10_1016_j_cellsig_2021_110123 crossref_primary_10_3390_cells13232005 crossref_primary_10_1080_03008207_2025_2469575 crossref_primary_10_3350_cmh_2024_0854 crossref_primary_10_1016_j_heliyon_2024_e35590 crossref_primary_10_3390_ijms26168031 crossref_primary_10_1093_rheumatology_keac411 crossref_primary_10_1016_j_metabol_2025_156323 crossref_primary_10_1016_j_phymed_2024_155755 crossref_primary_10_1038_s41419_025_07554_8 crossref_primary_10_53941_ijddp_v1i1_206 crossref_primary_10_1167_iovs_63_4_2 crossref_primary_10_1007_s00240_023_01491_x crossref_primary_10_3390_vetsci11040158 crossref_primary_10_3390_ijms24032963 crossref_primary_10_3389_fendo_2022_907757 crossref_primary_10_1186_s13075_023_03130_7 crossref_primary_10_1016_j_bbadis_2022_166541 crossref_primary_10_3389_fimmu_2022_1042983 crossref_primary_10_1073_pnas_2401899121 crossref_primary_10_1152_ajpcell_01043_2024 crossref_primary_10_3389_fmolb_2025_1583446 crossref_primary_10_1002_imt2_159 crossref_primary_10_1152_ajpcell_00307_2024 crossref_primary_10_1016_j_yjmcc_2025_09_005 crossref_primary_10_1088_1758_5090_adc8d4 crossref_primary_10_3389_fimmu_2025_1567657 crossref_primary_10_1016_j_celbio_2025_100052 crossref_primary_10_1016_j_mce_2024_112404 crossref_primary_10_3389_fimmu_2024_1462853 crossref_primary_10_3389_fphar_2022_800810 crossref_primary_10_3389_fphar_2024_1455058 crossref_primary_10_3390_ijms26136326 crossref_primary_10_1038_s41572_022_00386_2 crossref_primary_10_1002_jcb_30368 crossref_primary_10_3390_ijms26136202 crossref_primary_10_1039_D3BM01665J crossref_primary_10_3390_ijms24054882 crossref_primary_10_1111_bph_15967 crossref_primary_10_3389_fimmu_2024_1418897 crossref_primary_10_1136_gutjnl_2023_329650 crossref_primary_10_3390_cancers15030724 crossref_primary_10_1016_j_yexcr_2022_113195 crossref_primary_10_3389_fimmu_2024_1475923 crossref_primary_10_3390_ijms22063238 crossref_primary_10_1097_MD_0000000000030221 crossref_primary_10_1016_j_ecoenv_2025_117896 crossref_primary_10_3389_fimmu_2025_1663433 crossref_primary_10_1016_j_bioorg_2024_107332 crossref_primary_10_20517_evcna_2025_08 crossref_primary_10_1016_j_tice_2024_102671 crossref_primary_10_1093_bfgp_elae051 crossref_primary_10_3390_ijms23126456 crossref_primary_10_15283_ijsc25011 crossref_primary_10_1089_jir_2023_0001 crossref_primary_10_1155_2023_2828981 crossref_primary_10_1002_jex2_152 crossref_primary_10_1111_cea_14196 crossref_primary_10_1007_s00210_025_04410_6 crossref_primary_10_1016_j_jiph_2022_08_007 crossref_primary_10_1016_j_biopha_2025_118267 crossref_primary_10_3390_life13081781 crossref_primary_10_3389_fendo_2023_1274686 crossref_primary_10_3389_fphar_2021_706617 crossref_primary_10_4103_1673_5374_368299 crossref_primary_10_1186_s12967_024_05399_x crossref_primary_10_3389_fimmu_2024_1338922 crossref_primary_10_3390_ijms26178259 crossref_primary_10_3389_fcell_2023_1196023 crossref_primary_10_1016_j_intimp_2024_113931 crossref_primary_10_1111_exd_70026 crossref_primary_10_3389_fphys_2025_1577118 crossref_primary_10_3390_jcm14041347 crossref_primary_10_1002_btm2_10439 crossref_primary_10_1016_j_ijbiomac_2024_132844 crossref_primary_10_1016_j_trecan_2025_04_004 crossref_primary_10_1080_07853890_2024_2313680 crossref_primary_10_3389_fphar_2022_942168 crossref_primary_10_1002_2211_5463_13247 crossref_primary_10_1016_j_addr_2024_115317 crossref_primary_10_1016_j_colsurfb_2025_114657 crossref_primary_10_3389_fped_2022_1032653 crossref_primary_10_3390_ijms23105603 crossref_primary_10_53469_jcmp_2025_07_03__08 crossref_primary_10_1016_j_carpath_2024_107635 crossref_primary_10_1186_s10020_025_01093_w crossref_primary_10_3389_fgene_2022_985217 crossref_primary_10_1016_j_ejmech_2025_118011 crossref_primary_10_1055_s_0042_1755329 crossref_primary_10_3389_fphar_2024_1382094 crossref_primary_10_1186_s13020_025_01065_6 crossref_primary_10_1039_D2NR01954J crossref_primary_10_1186_s13148_024_01736_5 crossref_primary_10_1093_jleuko_qiae113 crossref_primary_10_3389_fendo_2022_801303 crossref_primary_10_3390_v16050799 crossref_primary_10_1007_s13369_025_10258_y crossref_primary_10_15407_biotech17_03_016 crossref_primary_10_1016_j_neuroscience_2024_04_004 crossref_primary_10_3390_biomedicines13040959 crossref_primary_10_3389_fcell_2021_715380 crossref_primary_10_1002_jor_25853 crossref_primary_10_1016_j_ijpharm_2024_124715 crossref_primary_10_2147_JMDH_S367591 crossref_primary_10_3390_cells11162595 crossref_primary_10_1161_CIRCEP_123_012683 crossref_primary_10_1136_ard_2023_224827 crossref_primary_10_1016_j_semcancer_2024_10_002 crossref_primary_10_1038_s41586_025_09449_2 crossref_primary_10_1016_j_semarthrit_2025_152811 crossref_primary_10_1016_j_cytogfr_2025_08_003 crossref_primary_10_1080_09553002_2024_2324476 crossref_primary_10_1007_s10735_020_09949_7 crossref_primary_10_1167_iovs_65_13_13 crossref_primary_10_1177_11795972241295619 crossref_primary_10_1016_j_fct_2025_115705 crossref_primary_10_1016_j_cyto_2025_156957 crossref_primary_10_3390_cells13110946 crossref_primary_10_1016_j_heliyon_2023_e15387 crossref_primary_10_1016_j_isci_2025_112778 crossref_primary_10_3390_cells14070536 crossref_primary_10_5812_numonthly_113161 crossref_primary_10_1002_smll_202305374 crossref_primary_10_1038_s42003_021_02479_2 crossref_primary_10_1038_s41467_024_53330_1 crossref_primary_10_3390_ijms232113479 crossref_primary_10_1186_s12929_021_00732_8 crossref_primary_10_1016_j_addr_2021_113831 crossref_primary_10_1161_JAHA_124_037890 crossref_primary_10_1007_s11886_021_01517_z crossref_primary_10_3390_ijms24032405 crossref_primary_10_1016_j_lfs_2023_121539 crossref_primary_10_3389_fneur_2024_1458385 crossref_primary_10_1063_5_0204393 crossref_primary_10_1080_10985549_2024_2426665 crossref_primary_10_1177_26348535241277625 crossref_primary_10_1016_j_bcp_2023_115475 crossref_primary_10_1186_s12967_023_04303_3 crossref_primary_10_3390_antiox14050506 crossref_primary_10_3390_ma14216447 crossref_primary_10_1007_s11010_024_05175_x crossref_primary_10_1007_s40883_021_00229_8 crossref_primary_10_1016_j_lfs_2022_120393 crossref_primary_10_1002_btm2_10427 crossref_primary_10_1038_s41467_025_62248_1 crossref_primary_10_1016_j_jare_2025_04_042 crossref_primary_10_1186_s12951_024_02429_0 crossref_primary_10_3390_ijms25179481 crossref_primary_10_1007_s11626_022_00734_2 crossref_primary_10_1007_s40674_021_00189_8 crossref_primary_10_1016_j_omtn_2023_06_017 crossref_primary_10_1016_j_phymed_2023_154793 crossref_primary_10_1016_j_tice_2025_102934 crossref_primary_10_1002_advs_202303283 crossref_primary_10_3390_cells11091386 crossref_primary_10_3390_molecules29020402 crossref_primary_10_1007_s11357_023_00785_7 crossref_primary_10_1038_s41586_024_08542_2 crossref_primary_10_1016_j_immuni_2021_04_021 crossref_primary_10_3389_fmed_2022_978120 crossref_primary_10_1002_adbi_202300315 crossref_primary_10_1016_j_bioactmat_2025_07_005 |
| ContentType | Journal Article |
| Copyright | 2020 Frangogiannis. |
| Copyright_xml | – notice: 2020 Frangogiannis. |
| DBID | 7X8 |
| DOI | 10.1084/jem.20190103 |
| DatabaseName | MEDLINE - Academic |
| DatabaseTitle | MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1540-9538 |
| GroupedDBID | --- -~X 18M 29K 2WC 36B 4.4 53G 5GY 5RE 5VS 7X8 ABOCM ABZEH ACGFO ACNCT ACPRK ADBBV AENEX AFRAH ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW C45 CS3 D-I DIK DU5 E3Z EBS EMB F5P F9R GX1 H13 HYE IH2 KQ8 L7B N9A O5R O5S OK1 P2P P6G R.V RHI SJN TR2 TRP UHB W8F WOQ |
| ID | FETCH-LOGICAL-c361t-e3c45fabae809cb40b4a537af13c5b3c68a9c05dfef4920c69f43cc375da9aa12 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 833 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000523659000006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1540-9538 |
| IngestDate | Thu Oct 02 06:13:49 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c361t-e3c45fabae809cb40b4a537af13c5b3c68a9c05dfef4920c69f43cc375da9aa12 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://rupress.org/jem/article-pdf/217/3/e20190103/1050682/jem_20190103.pdf |
| PQID | 2447836388 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2447836388 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-03-02 |
| PublicationDateYYYYMMDD | 2020-03-02 |
| PublicationDate_xml | – month: 03 year: 2020 text: 2020-03-02 day: 02 |
| PublicationDecade | 2020 |
| PublicationTitle | The Journal of experimental medicine |
| PublicationYear | 2020 |
| SSID | ssj0014456 |
| Score | 2.7263227 |
| SecondaryResourceType | review_article |
| Snippet | TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores... |
| SourceID | proquest |
| SourceType | Aggregation Database |
| StartPage | e20190103 |
| Title | Transforming growth factor-β in tissue fibrosis |
| URI | https://www.proquest.com/docview/2447836388 |
| Volume | 217 |
| WOSCitedRecordID | wos000523659000006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1NSwMxEB3UinjxW_xmBa-h2U2y2ZxExOLF4qFCbyVJE62HXetWf5g_xN_kJE0p3gTvy7I7M5k3LzPDA7hyQmgmc4XB68NKjrQEq_yCMOWlY9ZyT00Um5D9fjUcqsd04damscpFToyJetzYcEfeRRgKCwesqq7fpiSoRoXuapLQWIUOw1ImRLUcLrsInEf11jw0_xWe7DT4TivefXVhDT2gYZTL-p2GI7b0tv_7VTuwlarK7GYeBruw4uo92HhIffN9oINFfYpIlT0j9Z69ZHOpHfL9lU3qbBYdkHlkz007aQ_gqXc3uL0nSSuBWFbmM4J25cJro11FlTWcGq4Fk9rnzArDbFlpZakYe-e5KqgtlefoCibFWCut8-IQ1uqmdkeQcWZKJGWWa4nvkQoJiDTIVznlGuG8OIbLhS1GGIuhwaBr13y0o6U1Tv7wzClsFoG8hoGu4gw6Hs-bO4d1-4m__H4RXfkDYpyoXQ |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Transforming+growth+factor-%CE%B2+in+tissue+fibrosis&rft.jtitle=The+Journal+of+experimental+medicine&rft.au=Frangogiannis%2C+Nikolaos&rft.date=2020-03-02&rft.issn=1540-9538&rft.eissn=1540-9538&rft.volume=217&rft.issue=3&rft.spage=e20190103&rft_id=info:doi/10.1084%2Fjem.20190103&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1540-9538&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1540-9538&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1540-9538&client=summon |