Exploring kartogenin: advances in therapeutics and signaling mechanisms for musculoskeletal regeneration

Kartogenin (KGN) is a small synthetic heterocyclic molecule with chondrogenic and chondroprotective effects. Since its discovery, there has been a focus on regenerating cartilage damage and treating Osteoarthritis) OA(. In the treatment of OA, it’s important to target both cartilage and subchondral...

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Bibliographic Details
Published in:	Molecular biology reports Vol. 52; no. 1; p. 533
Main Authors:	Kiani, Sareh, Fallahi, Jafar, Tanideh, Nader, Razban, Vahid, Khajeh, Sahar
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01.12.2025 Springer Nature B.V
Subjects:	aesthetics ambient temperature Anilides - pharmacology Anilides - therapeutic use Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences Bone growth Bone healing Bone Regeneration - drug effects Cancellous bone Cartilage Cartilage diseases Cell differentiation Cell Differentiation - drug effects Cell signaling Chondrocytes Chondrocytes - drug effects Chondrocytes - metabolism Chondrogenesis Chondrogenesis - drug effects Clinical trials drugs heterocyclic compounds Histology Humans inflammation Life Sciences ligands Morphology musculoskeletal system Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - metabolism pain Phthalic Acids - pharmacology Phthalic Acids - therapeutic use Regeneration Regeneration - drug effects Review Signal Transduction - drug effects Sox9 protein SOX9 Transcription Factor - metabolism Subchondral bone therapeutics Toxicity Wound healing Wound Healing - drug effects Kartogenin Regeneration Signaling SOX9 Chondrogenesis
ISSN:	0301-4851, 1573-4978, 1573-4978
Online Access:	Get full text
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