Exploring kartogenin: advances in therapeutics and signaling mechanisms for musculoskeletal regeneration

Kartogenin (KGN) is a small synthetic heterocyclic molecule with chondrogenic and chondroprotective effects. Since its discovery, there has been a focus on regenerating cartilage damage and treating Osteoarthritis) OA(. In the treatment of OA, it’s important to target both cartilage and subchondral...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular biology reports Vol. 52; no. 1; p. 533
Main Authors:	Kiani, Sareh, Fallahi, Jafar, Tanideh, Nader, Razban, Vahid, Khajeh, Sahar
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01.12.2025 Springer Nature B.V
Subjects:	aesthetics ambient temperature Anilides - pharmacology Anilides - therapeutic use Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences Bone growth Bone healing Bone Regeneration - drug effects Cancellous bone Cartilage Cartilage diseases Cell differentiation Cell Differentiation - drug effects Cell signaling Chondrocytes Chondrocytes - drug effects Chondrocytes - metabolism Chondrogenesis Chondrogenesis - drug effects Clinical trials drugs heterocyclic compounds Histology Humans inflammation Life Sciences ligands Morphology musculoskeletal system Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - metabolism pain Phthalic Acids - pharmacology Phthalic Acids - therapeutic use Regeneration Regeneration - drug effects Review Signal Transduction - drug effects Sox9 protein SOX9 Transcription Factor - metabolism Subchondral bone therapeutics Toxicity Wound healing Wound Healing - drug effects Kartogenin Regeneration Signaling SOX9 Chondrogenesis
ISSN:	0301-4851, 1573-4978, 1573-4978
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Kartogenin (KGN) is a small synthetic heterocyclic molecule with chondrogenic and chondroprotective effects. Since its discovery, there has been a focus on regenerating cartilage damage and treating Osteoarthritis) OA(. In the treatment of OA, it’s important to target both cartilage and subchondral bone. KGN appears to reduce cartilage degradation and changes in subchondral trabecular bone. It can also reduce inflammation and pain behavior in vitro and in vivo. Additionally, KGN promotes chondrocyte differentiation and proliferation. It has been applied in many regenerative research fields including aesthetic procedures, limb skeletal growth, wound healing, tendon and bone regeneration and disc regeneration. KGN is similar to the natural ligands involved in cell signaling and differentiation. The master regulator of cartilage genes, Sex‑determining region‑box 9 protein (SOX9), is upregulated by KGN, making it an ideal drug to promote cartilage repair. Advantages of KGN include demonstrated low toxicity across various cell types and no apparent adverse effects in animals. It is highly stable, easily stored at room temperature, and can be synthesized inexpensively and efficiently. Analogues of KGN have entered clinical trials.
AbstractList	Kartogenin (KGN) is a small synthetic heterocyclic molecule with chondrogenic and chondroprotective effects. Since its discovery, there has been a focus on regenerating cartilage damage and treating Osteoarthritis) OA(. In the treatment of OA, it's important to target both cartilage and subchondral bone. KGN appears to reduce cartilage degradation and changes in subchondral trabecular bone. It can also reduce inflammation and pain behavior in vitro and in vivo. Additionally, KGN promotes chondrocyte differentiation and proliferation. It has been applied in many regenerative research fields including aesthetic procedures, limb skeletal growth, wound healing, tendon and bone regeneration and disc regeneration. KGN is similar to the natural ligands involved in cell signaling and differentiation. The master regulator of cartilage genes, Sex‑determining region‑box 9 protein (SOX9), is upregulated by KGN, making it an ideal drug to promote cartilage repair. Advantages of KGN include demonstrated low toxicity across various cell types and no apparent adverse effects in animals. It is highly stable, easily stored at room temperature, and can be synthesized inexpensively and efficiently. Analogues of KGN have entered clinical trials. Kartogenin (KGN) is a small synthetic heterocyclic molecule with chondrogenic and chondroprotective effects. Since its discovery, there has been a focus on regenerating cartilage damage and treating Osteoarthritis) OA(. In the treatment of OA, it's important to target both cartilage and subchondral bone. KGN appears to reduce cartilage degradation and changes in subchondral trabecular bone. It can also reduce inflammation and pain behavior in vitro and in vivo. Additionally, KGN promotes chondrocyte differentiation and proliferation. It has been applied in many regenerative research fields including aesthetic procedures, limb skeletal growth, wound healing, tendon and bone regeneration and disc regeneration. KGN is similar to the natural ligands involved in cell signaling and differentiation. The master regulator of cartilage genes, Sex‑determining region‑box 9 protein (SOX9), is upregulated by KGN, making it an ideal drug to promote cartilage repair. Advantages of KGN include demonstrated low toxicity across various cell types and no apparent adverse effects in animals. It is highly stable, easily stored at room temperature, and can be synthesized inexpensively and efficiently. Analogues of KGN have entered clinical trials.Kartogenin (KGN) is a small synthetic heterocyclic molecule with chondrogenic and chondroprotective effects. Since its discovery, there has been a focus on regenerating cartilage damage and treating Osteoarthritis) OA(. In the treatment of OA, it's important to target both cartilage and subchondral bone. KGN appears to reduce cartilage degradation and changes in subchondral trabecular bone. It can also reduce inflammation and pain behavior in vitro and in vivo. Additionally, KGN promotes chondrocyte differentiation and proliferation. It has been applied in many regenerative research fields including aesthetic procedures, limb skeletal growth, wound healing, tendon and bone regeneration and disc regeneration. KGN is similar to the natural ligands involved in cell signaling and differentiation. The master regulator of cartilage genes, Sex‑determining region‑box 9 protein (SOX9), is upregulated by KGN, making it an ideal drug to promote cartilage repair. Advantages of KGN include demonstrated low toxicity across various cell types and no apparent adverse effects in animals. It is highly stable, easily stored at room temperature, and can be synthesized inexpensively and efficiently. Analogues of KGN have entered clinical trials.
ArticleNumber	533
Author	Razban, Vahid Kiani, Sareh Khajeh, Sahar Fallahi, Jafar Tanideh, Nader
Author_xml	– sequence: 1 givenname: Sareh surname: Kiani fullname: Kiani, Sareh organization: Department of Molecular Medicine, School of Advanced Medical Science and Technologies, Shiraz University of Medical Sciences – sequence: 2 givenname: Jafar surname: Fallahi fullname: Fallahi, Jafar organization: Department of Molecular Medicine, School of Advanced Medical Science and Technologies, Shiraz University of Medical Sciences – sequence: 3 givenname: Nader surname: Tanideh fullname: Tanideh, Nader organization: Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Stem Cells Technology Research Center, Shiraz University of Medical Sciences – sequence: 4 givenname: Vahid surname: Razban fullname: Razban, Vahid email: razban_vahid@yahoo.com organization: Department of Molecular Medicine, School of Advanced Medical Science and Technologies, Shiraz University of Medical Sciences – sequence: 5 givenname: Sahar surname: Khajeh fullname: Khajeh, Sahar email: saharkh7@gmail.com organization: Orthopedic & Rehabilitation Research Center, Shiraz University of Medical Sciences
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/40456877$$D View this record in MEDLINE/PubMed
BookMark	eNqNkU1v1DAURS3Uik4Lf4AFssSGTaifHdsJO1T1S6rEBtaW47zMuE3sYCcV_Hs8nQISC8Tqbc69T7rnlByFGJCQN8A-AGP6PAMwISrGZQVMSVGpF2QDUouqbnVzRDZMMKjqRsIJOc35njFWg5YvyUnNaqkarTdkd_l9HmPyYUsfbFriFoMPH6ntH21wmKkPdNlhsjOui3eZ2tDT7LfBjvvIhG5ng89TpkNMdFqzW8eYH3DExY40Yakr4cXH8IocD3bM-Pr5npGvV5dfLm6qu8_Xtxef7ionFCyVk7xvhes46E4qrV2rONoGkDU111yDHqwU7dA47GQ50FrRsb5XApxSFsQZeX_onVP8tmJezOSzw3G0AeOajSgdTSO1lv-BguRCcr5H3_2F3sc1lRWeqLrhqkxaqLfP1NpN2Js5-cmmH-bX3AXgB8ClmHPC4TcCzOydmoNTU5yaJ6dGlZA4hPK894Tpz-9_pH4CPf2jpQ
Cites_doi	10.1016/j.msec.2017.07.005 10.1177/1947603514528354 10.3389/fchem.2019.00677 10.1016/j.msec.2019.02.071 10.1177/19476035221093072 10.1016/j.bbrc.2014.06.016 10.1002/term.2258 10.16966/2576-2826.158 10.1177/0300060519853399 10.1016/j.arthro.2018.06.040 10.1016/j.biomaterials.2014.08.042 10.1002/advs.202105571 10.1007/s00018-019-03017-4 10.1016/j.lfs.2017.11.028 10.3389/fbioe.2021.698614 10.7150/thno.38182 10.3390/ijms20030484 10.3390/ma14051053 10.1016/j.ydbio.2014.09.011 10.1016/j.joca.2020.02.814 10.1186/s13073-017-0407-3 10.1186/s10194-017-0741-2 10.1039/D2TB02203F 10.1016/j.compositesb.2022.110257 10.3390/molecules27123739 10.1155/2021/8830834 10.1186/s13287-019-1314-x 10.1007/s00223-020-00670-x 10.1016/j.biomaterials.2020.120539 10.1155/2018/1368142 10.1080/1061186X.2018.1464011 10.1177/0363546511404202 10.2106/JBJS.H.00835 10.1016/j.biomaterials.2019.119682 10.1038/boneres.2014.8 10.1007/s00018-019-03191-5 10.1016/j.semcancer.2020.04.008 10.1016/j.drudis.2013.11.011 10.1016/j.ajpath.2021.08.003 10.3389/fcell.2022.836285 10.3390/biom12030386 10.1177/1947603518809403 10.1016/S1348-8643(14)00032-9 10.1096/fj.201802137RRR 10.1080/10717544.2023.2254519 10.1128/MCB.25.3.1003-1012.2005 10.1016/j.nano.2017.05.011 10.23937/2469-570X/1410036 10.1186/s13287-020-01797-2 10.1016/j.jmst.2020.09.006 10.3390/jpm11040247 10.1177/0885328217717077 10.1016/j.jpedsurg.2011.10.013 10.1007/s11914-020-00586-3 10.1016/j.matdes.2022.110710 10.3389/fcell.2020.611757 10.1038/s41598-018-32206-7 10.1016/S1357-2725(01)00166-2 10.1016/j.bbagen.2017.02.005 10.3390/ijms21207463 10.1126/science.1215157 10.1080/10717544.2018.1461279 10.1111/os.12691 10.1177/23259671231155950 10.1016/j.mtbio.2022.100223 10.1007/s11596-019-1994-6 10.1177/19476035211029707 10.1038/s41419-021-03765-x 10.1016/j.jse.2020.06.013 10.3390/ijms24010390 10.1038/ijos.2015.14 10.3389/fcell.2021.664168 10.1359/jbmr.070502 10.1002/jbm.a.36300 10.1002/btm2.10364 10.12659/MSM.916696 10.3390/biom11010115 10.3390/ijms26062434 10.3390/ijms20246275 10.3390/ijms19102998 10.1007/s13770-021-00390-9 10.1016/j.chembiol.2015.11.008
ContentType	Journal Article
Copyright	The Author(s), under exclusive licence to Springer Nature B.V. 2025 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. 2025. The Author(s), under exclusive licence to Springer Nature B.V. Copyright Springer Nature B.V. Dec 2025
Copyright_xml	– notice: The Author(s), under exclusive licence to Springer Nature B.V. 2025 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. – notice: 2025. The Author(s), under exclusive licence to Springer Nature B.V. – notice: Copyright Springer Nature B.V. Dec 2025
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7TK 7TM 8FD FR3 K9. P64 RC3 7X8 7S9 L.6
DOI	10.1007/s11033-025-10653-6
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts Nucleic Acids Abstracts Technology Research Database Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic AGRICOLA AGRICOLA - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Genetics Abstracts Technology Research Database Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) Engineering Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic AGRICOLA AGRICOLA - Academic
DatabaseTitleList	MEDLINE AGRICOLA Genetics Abstracts MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Chemistry Biology
EISSN	1573-4978
EndPage	533
ExternalDocumentID	40456877 10_1007_s11033_025_10653_6
Genre	Journal Article Review
GroupedDBID	--- -Y2 -~C .86 .GJ .VR 06C 06D 0R~ 0VY 123 1SB 203 28- 29M 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3SX 4.4 406 408 409 40E 53G 5QI 5RE 5VS 67N 67Z 6NX 78A 7X7 88E 88I 8AO 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHBH AAHNG AAIAL AAJBT AAJKR AANXM AANZL AAPKM AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBRH ABBXA ABDBE ABDZT ABECU ABFSG ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABRTQ ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACGOD ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACSTC ACZOJ ADBBV ADHHG ADHIR ADHKG ADIMF ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AEZWR AFBBN AFDZB AFEXP AFGCZ AFHIU AFKRA AFLOW AFOHR AFQWF AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGQPQ AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHMBA AHPBZ AHSBF AHWEU AHYZX AIAKS AIGIU AIIXL AILAN AITGF AIXLP AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG ATHPR AVWKF AXYYD AYFIA AZFZN AZQEC B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BPHCQ BSONS BVXVI CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 DWQXO EBD EBLON EBS EIOEI EJD EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ7 GQ8 GXS H13 HCIFZ HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH LAK LK8 LLZTM M1P M2P M4Y M7P MA- N2Q NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 PF0 PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RIG RNI RNS ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TEORI TSG TSK TSV TUC TUS U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WH7 WJK WK6 WK8 YLTOR Z45 ZMTXR ZOVNA ZXP ~A9 ~EX ~KM AAYXX AFFHD CITATION CGR CUY CVF ECM EIF NPM 7TK 7TM 8FD FR3 K9. P64 RC3 7X8 7S9 L.6
ID	FETCH-LOGICAL-c361t-c52d93cb217b5677c962ea81e084272717fa539f8ceb59f819a3b0dd631c66a13
IEDL.DBID	RSV
ISICitedReferencesCount	0
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001501230700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0301-4851 1573-4978
IngestDate	Fri Nov 14 18:44:38 EST 2025 Fri Sep 05 15:56:58 EDT 2025 Wed Nov 05 14:53:04 EST 2025 Mon Jul 21 06:01:36 EDT 2025 Sat Nov 29 07:47:52 EST 2025 Mon Jul 21 06:07:49 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	Kartogenin Regeneration Signaling SOX9 Chondrogenesis
Language	English
License	2025. The Author(s), under exclusive licence to Springer Nature B.V.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c361t-c52d93cb217b5677c962ea81e084272717fa539f8ceb59f819a3b0dd631c66a13
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
PMID	40456877
PQID	3214826404
PQPubID	54080
PageCount	1
ParticipantIDs	proquest_miscellaneous_3271885775 proquest_miscellaneous_3215235225 proquest_journals_3214826404 pubmed_primary_40456877 crossref_primary_10_1007_s11033_025_10653_6 springer_journals_10_1007_s11033_025_10653_6
PublicationCentury	2000
PublicationDate	2025-12-01
PublicationDateYYYYMMDD	2025-12-01
PublicationDate_xml	– month: 12 year: 2025 text: 2025-12-01 day: 01
PublicationDecade	2020
PublicationPlace	Dordrecht
PublicationPlace_xml	– name: Dordrecht – name: Netherlands
PublicationSubtitle	An International Journal on Molecular and Cellular Biology
PublicationTitle	Molecular biology reports
PublicationTitleAbbrev	Mol Biol Rep
PublicationTitleAlternate	Mol Biol Rep
PublicationYear	2025
Publisher	Springer Netherlands Springer Nature B.V
Publisher_xml	– name: Springer Netherlands – name: Springer Nature B.V
References	P Zhang (10653_CR92) 2023; 11 RS Decker (10653_CR27) 2014; 395 JM Cuellar (10653_CR66) 2009; 91 Q Hu (10653_CR78) 2017; 13 S Zhang (10653_CR4) 2019; 9 10653_CR9 Y Jing (10653_CR42) 2020; 18 Y Ono (10653_CR34) 2014; 5 M Zhang (10653_CR76) 2022; 14 BK Wagner (10653_CR56) 2016; 23 10653_CR59 S Zhou (10653_CR40) 2019; 76 S-J Wang (10653_CR75) 2019; 7 10653_CR50 10653_CR51 MM Ampadiotaki (10653_CR54) 2021; 13 NA Householder (10653_CR18) 2023; 11 P Chen (10653_CR81) 2021; 70 Y Wang (10653_CR29) 2018; 2018 H Chen (10653_CR38) 2021; 9 P Chen (10653_CR2) 2023; 30 H Liu (10653_CR64) 2021; 18 W Yang (10653_CR79) 2019; 99 C Chen (10653_CR84) 2023; 8 C Huang (10653_CR89) 2021; 30 K Johnson (10653_CR1) 2012; 336 HJ Samvelyan (10653_CR17) 2021; 109 H Li (10653_CR23) 2018; 42 Y Zhang (10653_CR57) 2022; 246 Q Zhou (10653_CR44) 2019; 25 10653_CR45 C Yu (10653_CR72) 2021; 6 J Wang (10653_CR10) 2014; 450 JY Kwon (10653_CR25) 2018; 8 J Granados-Montiel (10653_CR8) 2021; 12 T Komori (10653_CR31) 2014; 12 Y Zhuang (10653_CR3) 2022; 10 J Yang (10653_CR41) 2015; 7 Y Zhou (10653_CR71) 2017; 11 H Jing (10653_CR61) 2020; 231 H Zhang (10653_CR58) 2025; 26 H Jing (10653_CR85) 2019; 33 J Ying (10653_CR48) 2018; 192 C Wang (10653_CR20) 2019; 47 B Wang (10653_CR21) 2022; 7 S Macmull (10653_CR22) 2011; 39 W Yang (10653_CR86) 2019; 99 D Ehirchiou (10653_CR16) 2020; 8 SA Garcia (10653_CR49) 2021; 191 B Lu (10653_CR12) 2014; 19 PM van der Kraan (10653_CR46) 2010; 12 CB Westin (10653_CR90) 2017; 80 CM Isacke (10653_CR63) 2002; 34 N Asgari (10653_CR88) 2020; 11 YR Chen (10653_CR6) 2022; 9 J Zhang (10653_CR67) 2014; 2 10653_CR39 10653_CR37 ML Kang (10653_CR77) 2014; 35 KTC Hede (10653_CR24) 2021; 13 10653_CR35 10653_CR32 DJ Duffy (10653_CR55) 2017; 9 W Fan (10653_CR15) 2018; 25 10653_CR74 F Liu (10653_CR87) 2019; 10 10653_CR73 T He (10653_CR62) 2022; 13 S Elder (10653_CR82) 2022; 27 H Huang (10653_CR70) 2018; 34 X Xu (10653_CR83) 2021; 269 DY Soung (10653_CR33) 2007; 22 H Zhou (10653_CR60) 2019; 18 WS Schou (10653_CR65) 2017; 18 A Strzelecka-Kiliszek (10653_CR53) 2017; 1861 R Chijimatsu (10653_CR43) 2019; 76 Q-X Hu (10653_CR52) 2017; 9 Y Zhao (10653_CR7) 2020; 12 A Atala (10653_CR11) 2012; 47 X Sun (10653_CR91) 2018; 46 J-y Cai (10653_CR13) 2019; 39 K Johnson (10653_CR14) 2020; 28 10653_CR5 K Qiao (10653_CR19) 2021; 9 N Yoshida (10653_CR30) 2005; 25 H Song (10653_CR36) 2020; 67 GI Im (10653_CR69) 2018; 106 10653_CR26 K Zha (10653_CR47) 2021; 2021 M Hou (10653_CR28) 2021; 12 G Cai (10653_CR68) 2019; 27 H Yin (10653_CR80) 2017; 32
References_xml	– volume: 80 start-page: 594 year: 2017 ident: 10653_CR90 publication-title: Mater Sci Eng C Mater Biol Appl doi: 10.1016/j.msec.2017.07.005 – volume: 5 start-page: 172 year: 2014 ident: 10653_CR34 publication-title: Cartilage doi: 10.1177/1947603514528354 – volume: 46 start-page: 1957 year: 2018 ident: 10653_CR91 publication-title: Artif Cells Nanomed Biotechnol – volume: 7 start-page: 677 year: 2019 ident: 10653_CR75 publication-title: Front Chem doi: 10.3389/fchem.2019.00677 – volume: 99 start-page: 1362 year: 2019 ident: 10653_CR86 publication-title: Mater Sci Engineering: C doi: 10.1016/j.msec.2019.02.071 – volume: 13 start-page: 194760352210930 year: 2022 ident: 10653_CR62 publication-title: Cartilage doi: 10.1177/19476035221093072 – volume: 450 start-page: 568 year: 2014 ident: 10653_CR10 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2014.06.016 – volume: 11 start-page: 3445 year: 2017 ident: 10653_CR71 publication-title: J Tissue Eng Regen Med doi: 10.1002/term.2258 – ident: 10653_CR74 doi: 10.16966/2576-2826.158 – volume: 47 start-page: 3261 year: 2019 ident: 10653_CR20 publication-title: J Int Med Res doi: 10.1177/0300060519853399 – volume: 34 start-page: 2588 year: 2018 ident: 10653_CR70 publication-title: Arthroscopy doi: 10.1016/j.arthro.2018.06.040 – volume: 35 start-page: 9984 year: 2014 ident: 10653_CR77 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.08.042 – volume: 9 start-page: e2105571 year: 2022 ident: 10653_CR6 publication-title: Adv Sci (Weinh) doi: 10.1002/advs.202105571 – volume: 76 start-page: 1653 year: 2019 ident: 10653_CR40 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-019-03017-4 – volume: 192 start-page: 84 year: 2018 ident: 10653_CR48 publication-title: Life Sci doi: 10.1016/j.lfs.2017.11.028 – volume: 18 start-page: 599 year: 2019 ident: 10653_CR60 publication-title: Oncol Lett – volume: 9 start-page: 698614 year: 2021 ident: 10653_CR19 publication-title: Front Bioeng Biotechnol doi: 10.3389/fbioe.2021.698614 – volume: 9 start-page: 7108 year: 2019 ident: 10653_CR4 publication-title: Theranostics doi: 10.7150/thno.38182 – ident: 10653_CR50 doi: 10.3390/ijms20030484 – ident: 10653_CR45 doi: 10.3390/ma14051053 – volume: 395 start-page: 255 year: 2014 ident: 10653_CR27 publication-title: Dev Biol doi: 10.1016/j.ydbio.2014.09.011 – volume: 28 start-page: S518 year: 2020 ident: 10653_CR14 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2020.02.814 – volume: 9 start-page: 15 year: 2017 ident: 10653_CR55 publication-title: Genome Med doi: 10.1186/s13073-017-0407-3 – volume: 18 start-page: 1 year: 2017 ident: 10653_CR65 publication-title: J Headache Pain doi: 10.1186/s10194-017-0741-2 – volume: 99 start-page: 1362 year: 2019 ident: 10653_CR79 publication-title: Mater Sci Eng C Mater Biol Appl doi: 10.1016/j.msec.2019.02.071 – volume: 11 start-page: 1240 year: 2023 ident: 10653_CR92 publication-title: J Mater Chem B doi: 10.1039/D2TB02203F – volume: 246 start-page: 110257 year: 2022 ident: 10653_CR57 publication-title: Compos Part B: Eng doi: 10.1016/j.compositesb.2022.110257 – volume: 27 start-page: 3739 year: 2022 ident: 10653_CR82 publication-title: Molecules doi: 10.3390/molecules27123739 – volume: 2021 start-page: 8830834 year: 2021 ident: 10653_CR47 publication-title: Stem Cells Int doi: 10.1155/2021/8830834 – volume: 10 start-page: 1 year: 2019 ident: 10653_CR87 publication-title: Stem Cell Res Ther doi: 10.1186/s13287-019-1314-x – volume: 109 start-page: 243 year: 2021 ident: 10653_CR17 publication-title: Calcif Tissue Int doi: 10.1007/s00223-020-00670-x – volume: 269 start-page: 120539 year: 2021 ident: 10653_CR83 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2020.120539 – ident: 10653_CR32 doi: 10.1155/2018/1368142 – volume: 6 start-page: 3568 year: 2021 ident: 10653_CR72 publication-title: Bioact Mater – volume: 27 start-page: 28 year: 2019 ident: 10653_CR68 publication-title: J Drug Target doi: 10.1080/1061186X.2018.1464011 – volume: 39 start-page: 1723 year: 2011 ident: 10653_CR22 publication-title: Am J Sports Med doi: 10.1177/0363546511404202 – volume: 91 start-page: 2313 year: 2009 ident: 10653_CR66 publication-title: JBJS doi: 10.2106/JBJS.H.00835 – volume: 231 start-page: 119682 year: 2020 ident: 10653_CR61 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2019.119682 – volume: 2 start-page: 14008 year: 2014 ident: 10653_CR67 publication-title: Bone Res doi: 10.1038/boneres.2014.8 – volume: 76 start-page: 3939 year: 2019 ident: 10653_CR43 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-019-03191-5 – volume: 67 start-page: 12 year: 2020 ident: 10653_CR36 publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2020.04.008 – volume: 19 start-page: 801 year: 2014 ident: 10653_CR12 publication-title: Drug Discovery Today doi: 10.1016/j.drudis.2013.11.011 – volume: 12 start-page: 1 year: 2010 ident: 10653_CR46 publication-title: Arthritis Res Therapy – volume: 191 start-page: 2042 year: 2021 ident: 10653_CR49 publication-title: Am J Pathol doi: 10.1016/j.ajpath.2021.08.003 – volume: 10 start-page: 836285 year: 2022 ident: 10653_CR3 publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2022.836285 – ident: 10653_CR35 doi: 10.3390/biom12030386 – volume: 13 start-page: e14709 year: 2021 ident: 10653_CR54 publication-title: Cureus – volume: 12 start-page: 102 year: 2021 ident: 10653_CR8 publication-title: Cartilage doi: 10.1177/1947603518809403 – volume: 12 start-page: 1 year: 2014 ident: 10653_CR31 publication-title: Oral Sci Int doi: 10.1016/S1348-8643(14)00032-9 – volume: 7 start-page: 478 year: 2022 ident: 10653_CR21 publication-title: Bioact Mater – volume: 9 start-page: 2296 year: 2017 ident: 10653_CR52 publication-title: Am J Translational Res – volume: 33 start-page: 5641 year: 2019 ident: 10653_CR85 publication-title: FASEB J doi: 10.1096/fj.201802137RRR – volume: 30 start-page: 2254519 year: 2023 ident: 10653_CR2 publication-title: Drug Deliv doi: 10.1080/10717544.2023.2254519 – volume: 25 start-page: 1003 year: 2005 ident: 10653_CR30 publication-title: Mol Cell Biol doi: 10.1128/MCB.25.3.1003-1012.2005 – volume: 13 start-page: 2189 year: 2017 ident: 10653_CR78 publication-title: Nanomedicine doi: 10.1016/j.nano.2017.05.011 – ident: 10653_CR5 doi: 10.23937/2469-570X/1410036 – volume: 42 start-page: 3181 year: 2018 ident: 10653_CR23 publication-title: Int J Mol Med – volume: 11 start-page: 1 year: 2020 ident: 10653_CR88 publication-title: Stem Cell Res Ther doi: 10.1186/s13287-020-01797-2 – volume: 70 start-page: 91 year: 2021 ident: 10653_CR81 publication-title: J Mater Sci Technol doi: 10.1016/j.jmst.2020.09.006 – ident: 10653_CR51 doi: 10.3390/jpm11040247 – volume: 32 start-page: 331 year: 2017 ident: 10653_CR80 publication-title: J Biomater Appl doi: 10.1177/0885328217717077 – volume: 47 start-page: 17 year: 2012 ident: 10653_CR11 publication-title: J Pediatr Surg doi: 10.1016/j.jpedsurg.2011.10.013 – volume: 18 start-page: 199 year: 2020 ident: 10653_CR42 publication-title: Curr Osteoporos Rep doi: 10.1007/s11914-020-00586-3 – ident: 10653_CR9 doi: 10.1016/j.matdes.2022.110710 – volume: 8 start-page: 611757 year: 2020 ident: 10653_CR16 publication-title: Front Cell Dev Biology doi: 10.3389/fcell.2020.611757 – volume: 8 start-page: 13832 year: 2018 ident: 10653_CR25 publication-title: Sci Rep doi: 10.1038/s41598-018-32206-7 – volume: 34 start-page: 718 year: 2002 ident: 10653_CR63 publication-title: Int J Biochem Cell Biol doi: 10.1016/S1357-2725(01)00166-2 – volume: 1861 start-page: 1009 year: 2017 ident: 10653_CR53 publication-title: Biochim Biophys Acta Gen Subj doi: 10.1016/j.bbagen.2017.02.005 – ident: 10653_CR59 doi: 10.3390/ijms21207463 – volume: 336 start-page: 717 year: 2012 ident: 10653_CR1 publication-title: Science doi: 10.1126/science.1215157 – volume: 25 start-page: 1004 year: 2018 ident: 10653_CR15 publication-title: Drug Delivery doi: 10.1080/10717544.2018.1461279 – volume: 12 start-page: 938 year: 2020 ident: 10653_CR7 publication-title: Orthop Surg doi: 10.1111/os.12691 – volume: 11 start-page: 232596712311559 year: 2023 ident: 10653_CR18 publication-title: Orthop J Sports Med doi: 10.1177/23259671231155950 – volume: 14 start-page: 100223 year: 2022 ident: 10653_CR76 publication-title: Mater Today Bio doi: 10.1016/j.mtbio.2022.100223 – volume: 39 start-page: 16 year: 2019 ident: 10653_CR13 publication-title: Curr Med Sci doi: 10.1007/s11596-019-1994-6 – volume: 13 start-page: 254S year: 2021 ident: 10653_CR24 publication-title: Cartilage doi: 10.1177/19476035211029707 – volume: 12 start-page: 483 year: 2021 ident: 10653_CR28 publication-title: Cell Death Dis doi: 10.1038/s41419-021-03765-x – volume: 30 start-page: 544 year: 2021 ident: 10653_CR89 publication-title: J Shoulder Elb Surg doi: 10.1016/j.jse.2020.06.013 – ident: 10653_CR73 doi: 10.3390/ijms24010390 – volume: 7 start-page: 73 year: 2015 ident: 10653_CR41 publication-title: Int J Oral Sci doi: 10.1038/ijos.2015.14 – volume: 9 start-page: 664168 year: 2021 ident: 10653_CR38 publication-title: Front Cell Dev Biology doi: 10.3389/fcell.2021.664168 – volume: 22 start-page: 1260 year: 2007 ident: 10653_CR33 publication-title: J Bone Miner Res doi: 10.1359/jbmr.070502 – volume: 106 start-page: 1141 year: 2018 ident: 10653_CR69 publication-title: J Biomed Mater Res A doi: 10.1002/jbm.a.36300 – volume: 8 start-page: e10364 year: 2023 ident: 10653_CR84 publication-title: Bioeng Transl Med doi: 10.1002/btm2.10364 – volume: 25 start-page: 4960 year: 2019 ident: 10653_CR44 publication-title: Med Sci Monitor: Int Med J Experimental Clin Res doi: 10.12659/MSM.916696 – ident: 10653_CR26 doi: 10.3390/biom11010115 – volume: 26 start-page: 2434 year: 2025 ident: 10653_CR58 publication-title: Int J Mol Sci doi: 10.3390/ijms26062434 – ident: 10653_CR37 doi: 10.3390/ijms20246275 – ident: 10653_CR39 doi: 10.3390/ijms19102998 – volume: 18 start-page: 989 year: 2021 ident: 10653_CR64 publication-title: Tissue Eng Regen Med doi: 10.1007/s13770-021-00390-9 – volume: 23 start-page: 3 year: 2016 ident: 10653_CR56 publication-title: Cell Chem Biology doi: 10.1016/j.chembiol.2015.11.008 – volume: 2018 start-page: 1368142 year: 2018 ident: 10653_CR29 publication-title: Oxidative Med Cell Longev doi: 10.1155/2018/1368142
SSID	ssj0004175
Score	2.4111896
SecondaryResourceType	review_article
Snippet	Kartogenin (KGN) is a small synthetic heterocyclic molecule with chondrogenic and chondroprotective effects. Since its discovery, there has been a focus on...
SourceID	proquest pubmed crossref springer
SourceType	Aggregation Database Index Database Publisher
StartPage	533
SubjectTerms	aesthetics ambient temperature Anilides - pharmacology Anilides - therapeutic use Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences Bone growth Bone healing Bone Regeneration - drug effects Cancellous bone Cartilage Cartilage diseases Cell differentiation Cell Differentiation - drug effects Cell signaling Chondrocytes Chondrocytes - drug effects Chondrocytes - metabolism Chondrogenesis Chondrogenesis - drug effects Clinical trials drugs heterocyclic compounds Histology Humans inflammation Life Sciences ligands Morphology musculoskeletal system Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - metabolism pain Phthalic Acids - pharmacology Phthalic Acids - therapeutic use Regeneration Regeneration - drug effects Review Signal Transduction - drug effects Sox9 protein SOX9 Transcription Factor - metabolism Subchondral bone therapeutics Toxicity Wound healing Wound Healing - drug effects
Title	Exploring kartogenin: advances in therapeutics and signaling mechanisms for musculoskeletal regeneration
URI	https://link.springer.com/article/10.1007/s11033-025-10653-6 https://www.ncbi.nlm.nih.gov/pubmed/40456877 https://www.proquest.com/docview/3214826404 https://www.proquest.com/docview/3215235225 https://www.proquest.com/docview/3271885775
Volume	52
WOSCitedRecordID	wos001501230700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAVX databaseName: Springer Nature Link Contemporary 1997-Present customDbUrl: eissn: 1573-4978 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0004175 issn: 0301-4851 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB7xquAClPJYXnIlbq2leONHzA0hECeEgFZ7i-zYKSu0WbTZReLfM_Ymu62glcoph4ys0czY81mebwbgxJWJTTFwqeRWUu61plY4Ra0ryyTxuhTWxWET6vo66_X0TUMKq9tq9_ZJMp7Uc7IbC3PHwvhVFhqqUrkIy5jusrAdb-9-ztmQLLbXDVifcgQUDVXm_TX-TEdvMOab99GYdi43PqbwJqw3MJOcTePiMyz4ags-TQdPvmzB6nk75-0LPMzK8MgjxtEQI6pfnZKmOKAm_Yr8RtKqiakcCVUfJhDZycAH6nC_HtQE4S8ZTEJh67B-xGyGsJ6M_K_Y1zq4fxt-XF7cn1_RZv4CLVLJxrQQXafTwuKtxQqpVKFl15uM-STjXcQ9TJVGpLrMCm8Ffpg2qU2ckykrpDQs3YGlalj5PSDahcZ2hiXOcK4VyjuLK3sthHCiTDvwrXVD_jRts5HPGyoHO-ZoxzzaMZcdOGw9lTdbrs7DxCW8K_GEd-Dr7DfaMryAmMoPJ1EGL94IOcW_ZDBdZ0IplNmdRsFMJR4AcKZUB763Lp8r8Hd99_9P_ADWujFqQtHMISyNRxN_BCvF87hfj45hUfWy4xjyr_nX-mg
linkProvider	Springer Nature
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB5RoKKX8uhrC7RG4kYtxRs_Ym4VAoEKq4qXuEV27LQrtNlqs1up_56xN9ktAirRUw4ZWaOZSeYbeb4ZgF1XJjbFwKWSW0m515pa4RS1riyTxOtSWBeXTaheL7u50d8bUljddru3V5LxTz0nu7GwdyysX2VhoCqVL2CJY8YKjXznF9dzNiSL43UD1qccAUVDlXn8jPvp6AHGfHA_GtPO0er_KbwGrxuYSb5O42IdFny1AS-niyf_bMDKQbvn7Q38nLXhkVuMoyFGVL_aJ01zQE36FfmLpFUTUzkSuj5MILKTgQ_U4X49qAnCXzKYhMbWYX2L2QxhPRn5H3GudXD_W7g6Orw8OKbN_gVapJKNaSG6TqeFxarFCqlUoWXXm4z5JONdxD1MlUakuswKbwU-mDapTZyTKSukNCx9B4vVsPIfgGgXBtsZljjDuVYo7yye7LUQwoky7cBe64b813TMRj4fqBzsmKMd82jHXHZgq_VU3nxydR42LmGtxBPegZ3Za7RluAExlR9OogwW3gg5xb9kMF1nQimUeT-NgplKPADgTKkOfGldPlfgaX0_Pk_8M6wcX56d5qcnvW-b8KobIyg00GzB4ng08duwXPwe9-vRpxj4d9hn_GQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LixQxEC50fV58rK_RVSN4c8N2pvPoeJPVQVGGBR_srUk6aR2W6VmmZwT_vVXp7pmVVUE89aGLUCQV6itSX30Az0Od-RwDl2vpNZfRWu5VMNyHus6yaGvlQxKbMNNpcXxsj86w-FO3-_Ak2XEaaEpTszo4DfXBlvgmSIOMpFgFDVfl-iJckiQaRPX6xy9bZqRIo3YJ93OJ4KKnzfx-jV9T0zm8ee6tNKWgyc3_d_4W3OjhJ3vVxcttuBCbXbjSCVL-2IVrh4P-2x34tmnPYycYXwuMtFnzkvVNAy2bNewMeatlrgmMukEcEdzZPBKleNbOW4awmM3X1PC6aE8wyyHcZ8v4Nc27prC4C58nbz4dvuW9LgOvci1WvFLjYPPKYzXjlTamsnocXSFiVsgx4iFhaqdyWxdV9Ao_wrrcZyHoXFRaO5Hfg51m0cQHwGyggXdOZMFJaQ3aB48rR6uUCqrOR_BiOJLytBu_UW4HLdM-lriPZdrHUo9gbzi1sr-KbUlKTFhDyUyO4NnmN-4lvYy4Ji7WyQYLcoSi6m82mMYLZQza3O8iYuOSJGBcGDOC_eH4tw782d-H_2b-FK4evZ6UH95N3z-C6-MUQNRXswc7q-U6PobL1ffVrF0-SXfgJx-IBVc
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exploring+kartogenin%3A+advances+in+therapeutics+and+signaling+mechanisms+for+musculoskeletal+regeneration&rft.jtitle=Molecular+biology+reports&rft.au=Kiani%2C+Sareh&rft.au=Fallahi%2C+Jafar&rft.au=Tanideh%2C+Nader&rft.au=Razban%2C+Vahid&rft.date=2025-12-01&rft.issn=1573-4978&rft.eissn=1573-4978&rft.volume=52&rft.issue=1&rft.spage=533&rft_id=info:doi/10.1007%2Fs11033-025-10653-6&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0301-4851&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0301-4851&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0301-4851&client=summon