Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency

We show that LPS-stimulated circulating CD14-positive monocytes from patients with common variable immunodeficiency (CVID) express a higher proportion of intracellular IL-12-positive cells than monocytes from patients with X-linked agammaglobulinemia or normal subjects. We used four-color flow cytom...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 164; no. 1; p. 488
Main Authors:	Cambronero, R, Sewell, W A, North, M E, Webster, A D, Farrant, J
Format:	Journal Article
Language:	English
Published:	United States 01.01.2000
Subjects:	Agammaglobulinemia - genetics Agammaglobulinemia - immunology Agammaglobulinemia - pathology CD28 Antigens - biosynthesis CD3 Complex - biosynthesis CD4-Positive T-Lymphocytes - metabolism CD56 Antigen - biosynthesis CD8-Positive T-Lymphocytes - metabolism Cell Count Common Variable Immunodeficiency - immunology Common Variable Immunodeficiency - pathology Dendritic Cells - immunology Dendritic Cells - metabolism Female Genetic Linkage - immunology Humans Interleukin-12 - biosynthesis Interleukin-12 - blood Interleukin-12 - deficiency Intracellular Fluid - immunology Intracellular Fluid - metabolism Killer Cells, Natural - metabolism Leukocyte Count Lipopolysaccharides - pharmacology Lymphocyte Depletion Macrophage Activation Male Monocytes - immunology Monocytes - metabolism T-Lymphocyte Subsets - metabolism Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - metabolism Up-Regulation - immunology X Chromosome - immunology
ISSN:	0022-1767
Online Access:	Get more information
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