Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis A Systematic Review and Meta-Analysis
Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A...
Saved in:
| Published in: | Medicine (Baltimore) Vol. 95; no. 11; p. e3079 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Wolters Kluwer Health
01.03.2016
|
| Subjects: | |
| ISSN: | 0025-7974, 1536-5964, 1536-5964 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A systematic search of the EMBASE, Scopus, Web of Science, and PubMed databases was performed to identify studies published before December 7, 2015 investigating the diagnostic accuracy of PCT for BM. The quality of the eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy method. The overall diagnostic accuracy of PCT detection in CSF or blood was pooled using the bivariate model. Twenty-two studies involving 2058 subjects were included in this systematic review and meta-analysis. The overall specificities and sensitivities were 0.86 and 0.80 for CSF PCT, and 0.97 and 0.95 for blood PCT, respectively. Areas under the summary receiver operating characteristic curves were 0.90 and 0.98 for CSF PCT and blood PCT, respectively. The major limitation of this systematic review and meta-analysis was the small number of studies included and the heterogeneous diagnostic thresholds adopted by eligible studies. Our meta-analysis shows that PCT is a useful biomarker for BM diagnosis. |
|---|---|
| AbstractList | Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A systematic search of the EMBASE, Scopus, Web of Science, and PubMed databases was performed to identify studies published before December 7, 2015 investigating the diagnostic accuracy of PCT for BM. The quality of the eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy method. The overall diagnostic accuracy of PCT detection in CSF or blood was pooled using the bivariate model. Twenty-two studies involving 2058 subjects were included in this systematic review and meta-analysis. The overall specificities and sensitivities were 0.86 and 0.80 for CSF PCT, and 0.97 and 0.95 for blood PCT, respectively. Areas under the summary receiver operating characteristic curves were 0.90 and 0.98 for CSF PCT and blood PCT, respectively. The major limitation of this systematic review and meta-analysis was the small number of studies included and the heterogeneous diagnostic thresholds adopted by eligible studies. Our meta-analysis shows that PCT is a useful biomarker for BM diagnosis.Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A systematic search of the EMBASE, Scopus, Web of Science, and PubMed databases was performed to identify studies published before December 7, 2015 investigating the diagnostic accuracy of PCT for BM. The quality of the eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy method. The overall diagnostic accuracy of PCT detection in CSF or blood was pooled using the bivariate model. Twenty-two studies involving 2058 subjects were included in this systematic review and meta-analysis. The overall specificities and sensitivities were 0.86 and 0.80 for CSF PCT, and 0.97 and 0.95 for blood PCT, respectively. Areas under the summary receiver operating characteristic curves were 0.90 and 0.98 for CSF PCT and blood PCT, respectively. The major limitation of this systematic review and meta-analysis was the small number of studies included and the heterogeneous diagnostic thresholds adopted by eligible studies. Our meta-analysis shows that PCT is a useful biomarker for BM diagnosis. Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A systematic search of the EMBASE, Scopus, Web of Science, and PubMed databases was performed to identify studies published before December 7, 2015 investigating the diagnostic accuracy of PCT for BM. The quality of the eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy method. The overall diagnostic accuracy of PCT detection in CSF or blood was pooled using the bivariate model. Twenty-two studies involving 2058 subjects were included in this systematic review and meta-analysis. The overall specificities and sensitivities were 0.86 and 0.80 for CSF PCT, and 0.97 and 0.95 for blood PCT, respectively. Areas under the summary receiver operating characteristic curves were 0.90 and 0.98 for CSF PCT and blood PCT, respectively. The major limitation of this systematic review and meta-analysis was the small number of studies included and the heterogeneous diagnostic thresholds adopted by eligible studies. Our meta-analysis shows that PCT is a useful biomarker for BM diagnosis. |
| Author | Tang, Qing-Qin Wei, Ting-Ting Hu, Zhi-De Zhou, Lin Ma, Ning Qin, Bao-Dong Zhong, Ren-Qian Wang, Li-Li |
| AuthorAffiliation | From the Department of Laboratory Diagnostics, Changzheng Hospital, The Second Military Medical University (T-TW, Z-DH, B-DQ, NM, Q-QT, L-LW, LZ, R-QZ); and Department of Laboratory Medicine, The General Hospital, Ji’nan Military Region of PLA, Ji’nan, Shandong, China (Z-DH) |
| AuthorAffiliation_xml | – name: From the Department of Laboratory Diagnostics, Changzheng Hospital, The Second Military Medical University (T-TW, Z-DH, B-DQ, NM, Q-QT, L-LW, LZ, R-QZ); and Department of Laboratory Medicine, The General Hospital, Ji’nan Military Region of PLA, Ji’nan, Shandong, China (Z-DH) |
| Author_xml | – sequence: 1 givenname: Ting-Ting surname: Wei fullname: Wei, Ting-Ting – sequence: 2 givenname: Zhi-De surname: Hu fullname: Hu, Zhi-De – sequence: 3 givenname: Bao-Dong surname: Qin fullname: Qin, Bao-Dong – sequence: 4 givenname: Ning surname: Ma fullname: Ma, Ning – sequence: 5 givenname: Qing-Qin surname: Tang fullname: Tang, Qing-Qin – sequence: 6 givenname: Li-Li surname: Wang fullname: Wang, Li-Li – sequence: 7 givenname: Lin surname: Zhou fullname: Zhou, Lin – sequence: 8 givenname: Ren-Qian surname: Zhong fullname: Zhong, Ren-Qian |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26986140$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UU1LAzEQDVKxH_oLBNmjl63JJptsLkJt_YJWPagXDyHNZmtkm9RkV-i_d0tbqUUcBgbmzXsP3nRByzqrAThFsI8gZxeTUR_uFIaMH4AOSjGNU05JC3QgTNKYcUbaoBvCB4QIs4QcgXZCeUYRgR3wNjJyZl2ojIoGStVeqmXkiujJOyVLZSpnjY2avpKq0t7IMproZjUzlQnRq_ahDtGDs9M_4GNwWMgy6JPN7IGXm-vn4V08fry9Hw7GscIUVnFeUI6LIk9zTBLEpWRKkbxAiBY8z3mCsCZyylQKpU41yhKaEZTJHCeUasU47oHLte6ins51rrStvCzFwpu59EvhpBG_EWvexcx9CZJhvtLvgfONgHeftQ6VmJugdFlKq10dBGKMpBjCdOV1tuv1Y7JNtDng6wPlXQheF6IJUVbGraxNKRAUq--JyUjsf6_h4j3uVv4_1jfJMp3x |
| CitedBy_id | crossref_primary_10_3390_antibiotics11060824 crossref_primary_10_1093_ofid_ofac480 crossref_primary_10_1097_MEJ_0000000000000721 crossref_primary_10_1007_s15016_021_9162_1 crossref_primary_10_3892_etm_2017_5543 crossref_primary_10_1016_j_ijantimicag_2019_07_016 crossref_primary_10_1183_20734735_0258_2019 crossref_primary_10_1371_journal_pone_0181449 crossref_primary_10_1136_bmj_p728 crossref_primary_10_1016_j_ajem_2024_11_093 crossref_primary_10_1016_j_idc_2017_05_003 crossref_primary_10_1093_cid_ciw781 crossref_primary_10_4103_0028_3886_344643 crossref_primary_10_3889_oamjms_2020_5497 crossref_primary_10_1080_1354750X_2022_2071991 crossref_primary_10_1111_jpc_16023 crossref_primary_10_1080_14737159_2022_2094705 crossref_primary_10_18019_1028_4427_2025_31_2_218_225 crossref_primary_10_1186_s42466_020_00098_6 crossref_primary_10_1001_jama_2022_20521 crossref_primary_10_1007_s15006_020_0158_8 crossref_primary_10_1016_j_cca_2019_06_010 crossref_primary_10_1038_s41390_020_0816_7 crossref_primary_10_17826_cumj_551752 crossref_primary_10_3390_jcm14020414 crossref_primary_10_1016_j_micpath_2025_107417 crossref_primary_10_1089_sur_2019_194 crossref_primary_10_1212_NXI_0000000000000425 crossref_primary_10_1136_practneurol_2016_001445 crossref_primary_10_3390_jcm7060148 crossref_primary_10_1016_j_jinf_2024_01_010 crossref_primary_10_1128_JCM_02018_16 crossref_primary_10_1177_0009922817728699 crossref_primary_10_3389_fcimb_2024_1439143 crossref_primary_10_1007_s15006_019_0716_0 crossref_primary_10_1016_j_cmi_2017_05_013 crossref_primary_10_1097_CCM_0000000000006017 crossref_primary_10_1016_j_wneu_2024_09_012 crossref_primary_10_1093_cid_ciy331 crossref_primary_10_20935_AcadMolBioGen7779 crossref_primary_10_1080_10408363_2022_2158779 crossref_primary_10_1097_CCM_0000000000006075 crossref_primary_10_1097_QCO_0000000000001105 crossref_primary_10_4103_2452_2473_357347 crossref_primary_10_7554_eLife_81151 crossref_primary_10_1016_j_jhin_2022_11_009 |
| Cites_doi | 10.4103/0974-777X.77290 10.1016/j.ijid.2015.07.011 10.1001/jama.1989.03430190084036 10.7326/0003-4819-151-4-200908180-00135 10.1371/journal.pone.0049894 10.1097/PEC.0000000000000273 10.3844/ajidsp.2010.93.97 10.1097/00003246-200006000-00024 10.3947/ic.2013.45.3.308 10.1080/00365540601113685 10.1001/archpedi.162.12.1157 10.1016/j.cca.2014.02.024 10.1056/NEJMoa040845 10.1016/j.jpeds.2006.02.034 10.1016/j.jiph.2013.07.005 10.1086/514793 10.1016/j.ajem.2006.07.012 10.1016/j.jclinepi.2005.02.022 10.3343/alm.2014.34.4.263 10.1016/S1473-3099(12)70323-7 10.1007/s15010-001-1165-z 10.1007/s12098-012-0933-3 10.1016/j.diagmicrobio.2012.02.010 10.1373/clinchem.2005.048595 10.1186/1865-1380-7-14 10.1016/j.clinbiochem.2014.10.007 10.1016/j.jclinepi.2005.01.016 10.7326/0003-4819-155-8-201110180-00009 10.1186/cc10254 10.1515/CCLM.2009.317 10.1086/513633 10.5858/arpa.2012-0198-RA 10.1002/jcla.21746 10.1371/journal.pone.0126444 10.1016/j.clinbiochem.2015.06.017 |
| ContentType | Journal Article |
| Copyright | Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. 2016 |
| Copyright_xml | – notice: Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. 2016 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1097/MD.0000000000003079 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1536-5964 |
| ExternalDocumentID | PMC4839921 26986140 10_1097_MD_0000000000003079 |
| Genre | Meta-Analysis Research Support, Non-U.S. Gov't Systematic Review Journal Article |
| GroupedDBID | --- .-D .3C .55 .GJ .XZ .Z2 01R 0R~ 1CY 354 40H 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 71W 77Y 7O~ AAAAV AAGIX AAHPQ AAIQE AAMOA AAQKA AARTV AASCR AAWTL AAXQO AAYEP AAYXX ABASU ABBUW ABCQX ABDIG ABFRF ABOCM ABVCZ ABXVJ ABZAD ABZZY ACBKD ACDDN ACEWG ACGFO ACGFS ACILI ACLDA ACWDW ACWRI ACXJB ACXNZ ACZKN ADFPA ADGGA ADHPY ADKSD ADNKB ADPDF ADSXY AE3 AE6 AEFWE AENEX AFBFQ AFDTB AFFNX AFUWQ AGOPY AHOMT AHQNM AHRYX AHVBC AIJEX AINUH AJCLO AJIOK AJNWD AJNYG AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC BQLVK BS7 BYPQX CITATION CS3 DIWNM DU5 E.X EBS EEVPB EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FD6 FIJ FL- FW0 GNXGY GQDEL GROUPED_DOAJ H0~ HLJTE HYE HZ~ H~9 IKREB IKYAY IN~ IPNFZ JF9 JG8 JK3 JK8 K8S KD2 KMI KQ8 L-C N4W N9A N~7 N~B N~M O9- OAG OAH OB2 OCUKA ODA OHH OK1 OL1 OLB OLG OLH OLU OLV OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVEED OVIDH OVLEI OWU OWV OWW OWZ OXXIT P-K P2P R58 RIG RLZ RPM RXW S4R S4S T8P TEORI TSPGW UNMZH V2I VVN W3M WOQ WOW X3V X3W X7M XXN XYM YFH YOC ZFV ZGI ZXP ZY1 ADGHP CGR CUY CVF ECM EIF NPM TAF 7X8 5PM |
| ID | FETCH-LOGICAL-c360t-df693ffd5d34219aa7cc4df116f9dd9213e4ab7c50ae5e18268418ad3266ec793 |
| ISICitedReferencesCount | 48 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000375211900023&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0025-7974 1536-5964 |
| IngestDate | Tue Nov 04 02:01:01 EST 2025 Sun Nov 09 10:41:04 EST 2025 Sat Jun 28 01:34:47 EDT 2025 Tue Nov 18 21:29:00 EST 2025 Sat Nov 29 02:40:01 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| License | This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c360t-df693ffd5d34219aa7cc4df116f9dd9213e4ab7c50ae5e18268418ad3266ec793 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Undefined-4 |
| OpenAccessLink | http://dx.doi.org/10.1097/MD.0000000000003079 |
| PMID | 26986140 |
| PQID | 1774530059 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4839921 proquest_miscellaneous_1774530059 pubmed_primary_26986140 crossref_citationtrail_10_1097_MD_0000000000003079 crossref_primary_10_1097_MD_0000000000003079 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-03-01 |
| PublicationDateYYYYMMDD | 2016-03-01 |
| PublicationDate_xml | – month: 03 year: 2016 text: 2016-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Medicine (Baltimore) |
| PublicationTitleAlternate | Medicine (Baltimore) |
| PublicationYear | 2016 |
| Publisher | Wolters Kluwer Health |
| Publisher_xml | – name: Wolters Kluwer Health |
| References | Dubos (R20-47-20210226) 2008; 162 Steinberg (R22-47-20210226) 2010; 5 Onal (R21-47-20210226) 2008; 13 Jereb (R16-47-20210226) 2001; 29 Viallon (R25-47-20210226) 2011; 15 Whiting (R8-47-20210226) 2011; 155 Alkholi (R24-47-20210226) 2011; 3 McCann (R7-47-20210226) 2012; 7 Umran (R32-47-20210226) 2014; 24 Ray (R18-47-20210226) 2007; 25 Rutjes (R39-47-20210226) 2005; 51 Hu (R12-47-20210226) 2015; 10 Meisner (R5-47-20210226) 2014; 34 Schwarz (R15-47-20210226) 2000; 28 Abdelkader (R31-47-20210226) 2014; 7 Cleophas (R37-47-20210226) 2009; 47 Li (R33-47-20210226) 2015; 48 Viallon (R14-47-20210226) 1999; 28 Knudsen (R19-47-20210226) 2007; 39 Moher (R9-47-20210226) 2009; 151 Reitsma (R10-47-20210226) 2005; 58 Prasad (R28-47-20210226) 2013; 80 Schmidt (R40-47-20210226) 2013; 137 Ibrahim (R26-47-20210226) 2011; 61 Mekitarian Filho (R3-47-20210226) 2014; 7 Deeks (R11-47-20210226) 2005; 58 Dubos (R17-47-20210226) 2006; 149 Shen (R34-47-20210226) 2015; 48 Spanos (R1-47-20210226) 1989; 262 Hu (R38-47-20210226) 2014; 433 Casado (R29-47-20210226) 2014; 30 van de Beek (R2-47-20210226) 2004; 351 Gendrel (R13-47-20210226) 1997; 24 Wacker (R6-47-20210226) 2013; 13 Vikse (R35-47-20210226) 2015; 38 Makoo (R23-47-20210226) 2010; 6 White (R4-47-20210226) 2012; 73 Choi (R27-47-20210226) 2013; 45 Konstantinidis (R30-47-20210226) 2014; 29 |
| References_xml | – volume: 3 start-page: 14 year: 2011 ident: R24-47-20210226 article-title: Serum procalcitonin in viral and bacterial meningitis publication-title: J Glob Infect Dis doi: 10.4103/0974-777X.77290 – volume: 38 start-page: 68 year: 2015 ident: R35-47-20210226 article-title: The role of serum procalcitonin in the diagnosis of bacterial meningitis in adults: a systematic review and meta-analysis publication-title: Int J Infect Dis doi: 10.1016/j.ijid.2015.07.011 – volume: 262 start-page: 2700 year: 1989 ident: R1-47-20210226 article-title: Differential diagnosis of acute meningitis. An analysis of the predictive value of initial observations publication-title: JAMA doi: 10.1001/jama.1989.03430190084036 – volume: 151 start-page: 264 year: 2009 ident: R9-47-20210226 article-title: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement publication-title: Ann Intern Med doi: 10.7326/0003-4819-151-4-200908180-00135 – volume: 7 start-page: e49894 year: 2012 ident: R7-47-20210226 article-title: Ability of procalcitonin to discriminate infection from non-infective inflammation using two pleural disease settings publication-title: PLoS One doi: 10.1371/journal.pone.0049894 – volume: 30 start-page: 849 year: 2014 ident: R29-47-20210226 article-title: Acute meningitis in the pediatric emergency department: diagnostic yield of procalcitonin and C-reactive protein publication-title: Pediatr Emerg Care doi: 10.1097/PEC.0000000000000273 – volume: 6 start-page: 93 year: 2010 ident: R23-47-20210226 article-title: Diagnostic value of serum and cerebrospinal fluid procalcitonin in differentiation bacterial from Aseptic meningitis publication-title: Am J Infect Dis doi: 10.3844/ajidsp.2010.93.97 – volume: 28 start-page: 1828 year: 2000 ident: R15-47-20210226 article-title: Serum procalcitonin levels in bacterial and abacterial meningitis publication-title: Crit Care Med doi: 10.1097/00003246-200006000-00024 – volume: 5 start-page: 57 year: 2010 ident: R22-47-20210226 article-title: Optimization of a diagnostic procedure for children with preliminary diagnosis of “meningitis” publication-title: J Pediatr Infect Dis – volume: 61 start-page: 346 year: 2011 ident: R26-47-20210226 article-title: Diagnostic value of serum procalcitonin levels in children with meningitis: a comparison with blood leukocyte count and C-reactive protein publication-title: J Pak Med Assoc – volume: 45 start-page: 308 year: 2013 ident: R27-47-20210226 article-title: Predictive performance of serum procalcitonin for the diagnosis of bacterial meningitis after neurosurgery publication-title: Infect Chemother doi: 10.3947/ic.2013.45.3.308 – volume: 39 start-page: 542 year: 2007 ident: R19-47-20210226 article-title: Diagnostic value of soluble CD163 serum levels in patients suspected of meningitis: comparison with CRP and procalcitonin publication-title: Scand J Infect Dis doi: 10.1080/00365540601113685 – volume: 162 start-page: 1157 year: 2008 ident: R20-47-20210226 article-title: Serum procalcitonin level and other biological markers to distinguish between bacterial and aseptic meningitis in children: a European multicenter case cohort study publication-title: Arch Pediatr Adolesc Med doi: 10.1001/archpedi.162.12.1157 – volume: 433 start-page: 44 year: 2014 ident: R38-47-20210226 article-title: Diagnostic accuracy of osteopontin for malignant pleural mesothelioma: a systematic review and meta-analysis publication-title: Clin Chim Acta doi: 10.1016/j.cca.2014.02.024 – volume: 351 start-page: 1849 year: 2004 ident: R2-47-20210226 article-title: Clinical features and prognostic factors in adults with bacterial meningitis publication-title: N Engl J Med doi: 10.1056/NEJMoa040845 – volume: 149 start-page: 72 year: 2006 ident: R17-47-20210226 article-title: Serum procalcitonin and other biologic markers to distinguish between bacterial and aseptic meningitis publication-title: J Pediatr doi: 10.1016/j.jpeds.2006.02.034 – volume: 7 start-page: 106 year: 2014 ident: R31-47-20210226 article-title: Serum procalcitonin in Egyptian patients with acute meningitis and a negative direct cerebrospinal fluid examination publication-title: J Infect Public Health doi: 10.1016/j.jiph.2013.07.005 – volume: 28 start-page: 1313 year: 1999 ident: R14-47-20210226 article-title: High sensitivity and specificity of serum procalcitonin levels in adults with bacterial meningitis publication-title: Clin Infect Dis doi: 10.1086/514793 – volume: 25 start-page: 179 year: 2007 ident: R18-47-20210226 article-title: Accuracy of the cerebrospinal fluid results to differentiate bacterial from non bacterial meningitis, in case of negative gram-stained smear publication-title: Am J Emerg Med doi: 10.1016/j.ajem.2006.07.012 – volume: 58 start-page: 982 year: 2005 ident: R10-47-20210226 article-title: Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2005.02.022 – volume: 34 start-page: 263 year: 2014 ident: R5-47-20210226 article-title: Update on procalcitonin measurements publication-title: Ann Lab Med doi: 10.3343/alm.2014.34.4.263 – volume: 13 start-page: 426 year: 2013 ident: R6-47-20210226 article-title: Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(12)70323-7 – volume: 29 start-page: 209 year: 2001 ident: R16-47-20210226 article-title: Predictive value of serum and cerebrospinal fluid procalcitonin levels for the diagnosis of bacterial meningitis publication-title: Infection doi: 10.1007/s15010-001-1165-z – volume: 13 start-page: 91 year: 2008 ident: R21-47-20210226 article-title: A new parameter in the differential diagnosis of bacterial and viral meningitis publication-title: Neurosciences – volume: 80 start-page: 365 year: 2013 ident: R28-47-20210226 article-title: Serum procalcitonin in septic meningitis publication-title: Indian J Pediatr doi: 10.1007/s12098-012-0933-3 – volume: 73 start-page: 27 year: 2012 ident: R4-47-20210226 article-title: The utility of cerebrospinal fluid parameters in the early microbiological assessment of meningitis publication-title: Diagn Microbiol Infect Dis doi: 10.1016/j.diagmicrobio.2012.02.010 – volume: 51 start-page: 1335 year: 2005 ident: R39-47-20210226 article-title: Case-control and two-gate designs in diagnostic accuracy studies publication-title: Clin Chem doi: 10.1373/clinchem.2005.048595 – volume: 7 start-page: 14 year: 2014 ident: R3-47-20210226 article-title: Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children publication-title: Int J Emerg Med doi: 10.1186/1865-1380-7-14 – volume: 48 start-page: 50 year: 2015 ident: R33-47-20210226 article-title: The diagnostic value of cerebrospinal fluids procalcitonin and lactate for the differential diagnosis of post-neurosurgical bacterial meningitis and aseptic meningitis publication-title: Clin Biochem doi: 10.1016/j.clinbiochem.2014.10.007 – volume: 58 start-page: 882 year: 2005 ident: R11-47-20210226 article-title: The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2005.01.016 – volume: 155 start-page: 529 year: 2011 ident: R8-47-20210226 article-title: QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies publication-title: Ann Intern Med doi: 10.7326/0003-4819-155-8-201110180-00009 – volume: 15 start-page: R136 year: 2011 ident: R25-47-20210226 article-title: Meningitis in adult patients with a negative direct cerebrospinal fluid examination: value of cytochemical markers for differential diagnosis publication-title: Crit Care doi: 10.1186/cc10254 – volume: 24 start-page: 739 year: 2014 ident: R32-47-20210226 article-title: Diagnostic value of serum procalcitonin level in differentiating bacterial from nonbacterial meningitis in children publication-title: Iran J Pediatr – volume: 47 start-page: 1351 year: 2009 ident: R37-47-20210226 article-title: Meta-analyses of diagnostic studies publication-title: Clin Chem Lab Med doi: 10.1515/CCLM.2009.317 – volume: 24 start-page: 1240 year: 1997 ident: R13-47-20210226 article-title: Measurement of procalcitonin levels in children with bacterial or viral meningitis publication-title: Clin Infect Dis doi: 10.1086/513633 – volume: 137 start-page: 558 year: 2013 ident: R40-47-20210226 article-title: Understanding sources of bias in diagnostic accuracy studies publication-title: Arch Pathol Lab Med doi: 10.5858/arpa.2012-0198-RA – volume: 29 start-page: 169 year: 2014 ident: R30-47-20210226 article-title: Can procalcitonin in cerebrospinal fluid be a diagnostic tool for meningitis? publication-title: J Clin Lab Anal doi: 10.1002/jcla.21746 – volume: 10 start-page: e0126444 year: 2015 ident: R12-47-20210226 article-title: Diagnostic value of osteopontin in ovarian cancer: A meta-analysis and systematic review publication-title: PLoS One doi: 10.1371/journal.pone.0126444 – volume: 48 start-page: 1079 year: 2015 ident: R34-47-20210226 article-title: Direct comparison of the diagnostic accuracy between blood and cerebrospinal fluid procalcitonin levels in patients with meningitis publication-title: Clin Biochem doi: 10.1016/j.clinbiochem.2015.06.017 |
| SSID | ssj0013724 |
| Score | 2.424271 |
| SecondaryResourceType | review_article |
| Snippet | Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but... |
| SourceID | pubmedcentral proquest pubmed crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e3079 |
| SubjectTerms | Calcitonin - blood Calcitonin Gene-Related Peptide Diagnosis, Differential Humans Meningitis, Bacterial - blood Meningitis, Bacterial - diagnosis Protein Precursors - blood Systematic Review and Meta-Analysis |
| Subtitle | A Systematic Review and Meta-Analysis |
| Title | Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/26986140 https://www.proquest.com/docview/1774530059 https://pubmed.ncbi.nlm.nih.gov/PMC4839921 |
| Volume | 95 |
| WOSCitedRecordID | wos000375211900023&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1536-5964 dateEnd: 20241231 omitProxy: false ssIdentifier: ssj0013724 issn: 0025-7974 databaseCode: DOA dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ba9swFBZpN8Zexq5ttrV4sLdNLPJN1mM7r-wlZYOMBfZgFF1aQ7BLmpS-7L_vyLJkOwtlfVgwJkiycfJ9OjrHkr6D0HtOoVwygcMwS3EMHj5mIeFYKx0RBTBrbZNN0PPzbD5n30aj324vzM2SVlV2e8uu_ivUUAZgm62z94Db3xQK4DuADmeAHc7_BHxuF88ZIdYTITYrk8_dLHRbmVFLQAc2cqpwnFqd5mZvrk1bVF5_MK_PNmD66mqxo7rvyU7bSXnjop7y5bq0K3b9e4WfqrRcqC7wzI2PDX-a-ZDLEueeU9_bpPG8xnndNZ1yy9W2pH03QdJucZbfK2AEMW0eHmdvbVJNxyvSs54KDA7badetXvA0t3KT7ce1Hqpob41ufs2hm22f5sX2TfbQg5AmjLmI3E1C0TD2GX_hRzjRKkY_7XiSoWPzV7Syvei258XMnqInbfgRnFjaPEMjVT1HjxyWL9Cvjj2BY09Q62DAngAOz56go0dg2RP02dOrfol-nH2Zff6K2_wbWETpZI2lTlmktUxkFMPAxjkVIpaakFQzKaFLRyrmCyqSCVeJMoFqFpOMS4gIUiXA8L9C-1VdqUMUJEkmVAQOGYX4m0YRUzIWEOsvkjCihMsxCt2fV4hWnN7kSFkWd8A2Rh_9RVdWm-Xu5u8cKgXYUDMxxitVb64LAjFQYvI2QJsDi5K_YZiyDFzYyRjRAX6-gdFnH9ZU5WWj0x5nRvWZvL7fY75Bj7uu9Bbtr1cbdYQeihsAanWM9ug8O254-gc9M6rG |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Diagnostic+Accuracy+of+Procalcitonin+in+Bacterial+Meningitis+Versus+Nonbacterial+Meningitis&rft.jtitle=Medicine+%28Baltimore%29&rft.au=Wei%2C+Ting-Ting&rft.au=Hu%2C+Zhi-De&rft.au=Qin%2C+Bao-Dong&rft.au=Ma%2C+Ning&rft.date=2016-03-01&rft.issn=0025-7974&rft.volume=95&rft.issue=11&rft.spage=e3079&rft_id=info:doi/10.1097%2FMD.0000000000003079&rft.externalDBID=n%2Fa&rft.externalDocID=10_1097_MD_0000000000003079 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0025-7974&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0025-7974&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0025-7974&client=summon |