No influence of noradrenaline manipulation on acute exercise-induced increase of brain-derived neurotrophic factor

To examine the influence of a selective noradrenaline reuptake inhibitor (SNRI) on the exercise-induced increase in circulating brain-derived neurotrophic factor (BDNF). In a double-blind, placebo-controlled, crossover design, 11 young, healthy male subjects were treated with either placebo or rebox...

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Published in:Medicine and science in sports and exercise Vol. 40; no. 11; p. 1990
Main Authors: Goekint, Maaike, Heyman, Elsa, Roelands, Bart, Njemini, Rose, Bautmans, Ivan, Mets, Tony, Meeusen, Romain
Format: Journal Article
Language:English
Published: United States 01.11.2008
Subjects:
Adolescent
Adrenergic Uptake Inhibitors - administration & dosage
Adrenergic Uptake Inhibitors - pharmacology
Adult
Bicycling - physiology
Brain-Derived Neurotrophic Factor - drug effects
Cognition - drug effects
Cross-Over Studies
Double-Blind Method
Humans
Male
Morpholines - administration & dosage
Morpholines - pharmacology
Physical Exertion - physiology
Placebos
Young Adult
ISSN:1530-0315, 1530-0315
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Summary:To examine the influence of a selective noradrenaline reuptake inhibitor (SNRI) on the exercise-induced increase in circulating brain-derived neurotrophic factor (BDNF). In a double-blind, placebo-controlled, crossover design, 11 young, healthy male subjects were treated with either placebo or reboxetine. On each occasion, they performed a 60-min cycling exercise at 55% of their maximal power output (Wmax) followed by a time trial (TT) at 75% of Wmax. HR and ratings of perceived exertion were measured. Blood samples were taken at four time points. An increase in serum BDNF was found after exercise without any influence of drug administration on BDNF levels. Serum BDNF returned to resting levels after 15 min of recovery. Time trial (TT) performance was significantly worse after reboxetine intake. Serum cortisol increased in both trials during and after exercise and was significantly higher in the reboxetine trial. Also, HR was increased with reboxetine intake, probably because of the sympathomimetic effect of SNRI. Midterm memory was significantly impaired after the exercise protocol without difference between reboxetine and placebo trial. The administration of an SNRI has no effect on the exercise-induced increase in BDNF. However, effects were seen on serum cortisol, HR, and memory. Future research should focus on the effect of regular exercise training in combination with several reuptake inhibitors in both healthy and depressed subjects on BDNF and memory.
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ISSN:1530-0315
1530-0315
DOI:10.1249/MSS.0b013e31817eee85