Quantitative assessment of dose accumulation uncertainty using a commercial deformable image registration algorithm in adaptive intensity-modulated proton therapy for prostate cancer

•The impact of DIR error on prostate proton dose accumulation was evaluated.•A well-regularized DIR algorithm was used as a reference.•The geometric and dosimetric DIR error was assessed on a structure-basis.•Dose variation due to anatomical change exceeded the DIR uncertainties.•The structure-guide...

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Bibliographic Details
Published in:	Physica medica Vol. 135; p. 105011
Main Authors:	Xu, Yihang, Ford, John Chetley, Padgett, Kyle R., Dogan, Nesrin
Format:	Journal Article
Language:	English
Published:	Italy Elsevier Ltd 01.07.2025
Subjects:	Adaptive IMPT Algorithms Dose accumulation uncertainty Humans Image Processing, Computer-Assisted - methods Male Prostate cancer Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - radiotherapy Proton Therapy Radiation Dosage Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Intensity-Modulated - methods Tomography, X-Ray Computed Uncertainty OAR ART IMRT CTV prCT GTV IMPT Dose accumulation uncertainty SD RBE SICLE MFO Accum_ref Adaptive IMPT pCT rCT Doseref DMP Dosetest ICE DIR ROI SGD Accum_DMP RE Accum_DMP+SGD DVF DVFref Prostate cancer DVFtest
ISSN:	1120-1797, 1724-191X, 1724-191X
Online Access:	Get full text
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