Trends in Bicuspid Aortic Valve–Attributable Death in the United States From 2010 to 2020

Population-based data on bicuspid aortic valve (BAV)-attributable mortality trends in the United States are limited. This study assessed trends in BAV-attributable death in the United States from 2010 to 2020, evaluating differences by sex, ethnicity, urbanization, and census region. Data were extra...

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Bibliographic Details
Published in:Journal of the American Heart Association Vol. 14; no. 21; p. e041725
Main Authors: Zuin, Marco, Campia, Umberto, De la Cruz, Kim I., Singh, Michael, Piazza, Gregory
Format: Journal Article
Language:English
Published: England Wiley 04.11.2025
Subjects:
Adolescent
Adult
Age Distribution
Aged
bicuspid aortic valve
Bicuspid Aortic Valve Disease - ethnology
Bicuspid Aortic Valve Disease - mortality
Cause of Death - trends
death
Female
Humans
Male
Middle Aged
Risk Factors
Sex Distribution
Sex Factors
Time Factors
trend
United States - epidemiology
valvular heart disease
Young Adult
United States
valvular heart disease
death
bicuspid aortic valve
trend
ISSN:2047-9980, 2047-9980
Online Access:Get full text
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Summary:Population-based data on bicuspid aortic valve (BAV)-attributable mortality trends in the United States are limited. This study assessed trends in BAV-attributable death in the United States from 2010 to 2020, evaluating differences by sex, ethnicity, urbanization, and census region. Data were extracted from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research system. Trends in age-adjusted mortality rates per 100 000 population were analyzed using JoinPoint regression to calculate average annual percentage change and annual percentage change, with corresponding 95% CIs. From 2010 and 2020, 3537 deaths were attributable to BAV, corresponding to 11.7 deaths per 100 000 population. Age-adjusted mortality rates increased linearly, with an average annual percentage change of +4.6% (95% CI, 2.8-6.5; 0.001). Women experienced a steeper increase (average annual percentage change, +8.0% [95% CI, 3.3-12.9]; 0.001) compared with men (average annual percentage change, +5.3% [95% CI, 3.6-7.0]; 0.001). Mortality trends were more pronounced among Hispanic/Latinx individuals and those aged <65 years. No significant differences between urban and rural settings were observed ( 0.35), while the South accounted for the highest proportion of deaths (31.1%). BAV-attributable mortality has increased over the past decade, with significant disparities by sex, age, and region. These results highlight the critical importance of developing targeted health care approaches and enhancing strategic management techniques to address specific population BAV-related health concerns.
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ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.125.041725