Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin: Lipid composition and thermal phase behavior of the stratum corneum

The present report is a part of our continuing efforts to explore the utility of the rat epidermal keratinocyte organotypic culture (ROC) as an alternative model to human skin in transdermal drug delivery and skin irritation studies of new chemical entities and formulations. The aim of the present s...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1778; no. 4; pp. 824 - 834
Main Authors:	Pappinen, Sari, Hermansson, Martin, Kuntsche, Judith, Somerharju, Pentti, Wertz, Philip, Urtti, Arto, Suhonen, Marjukka
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2008
Subjects:	Animals Calorimetry, Differential Scanning Ceramides - analysis Ceramides - chemistry Ceramides - classification Chromatography, Thin Layer DSC Epidermis - chemistry Epidermis - cytology Humans Keratinocytes - chemistry Keratinocytes - cytology Lipid composition Lipids - analysis Lipids - chemistry Mass Spectrometry Models, Biological Organ Culture Techniques Rats Reconstructed epidermis ROC Stratum corneum Temperature TLC FFA NP Reconstructed epidermis Lipid composition Stratum corneum NS AH EOP ROC EOS TLC AP AS DSC REK NH EOH
ISSN:	0005-2736, 0006-3002, 1879-2642
Online Access:	Get full text
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